Effect of Antiepileptic drugs on lipid profile in children with Epilepsy

Nadkarni, Jayashree; Uikey, Deepak Kumar; Sharma, Utkarsh; Dwivedi, Rashmi

doi:10.17511/ijmrr.2014.i02.09

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Epilepsy is the most common neurological disorder in children characterized by spontaneous propensity for recurrent and unprovoked seizures and it remains a Challenge to treat. 11,12 Despite of overall increase in number of antiepileptic drugs, more than 25% of children with childhood epilepsy continue to have seizures. 12 The overall aim of antiepileptic treatment should be to control seizures with the lowest possible occurrence of adverse effects, allowing the child to become an active member of the community and this at the lowest possible overall cost.…”

Section: Discussionmentioning

confidence: 99%

Drug utilization pattern of antiepileptic agents among pediatric epilepsy at tertiary care teaching hospital of Gujarat: a cross sectional study

Dave¹,

Trivedi

2018

Int J Basic Clin Pharmacol

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Background: Epilepsy is one of the most common neurological disorders characterized by recurrent episodic paroxysmal involuntary clinical events associated with abnormal electrical activity from the neurons. Without the knowledge of how drugs are being prescribed and used, it is difficult to initiate discussion on rationale drug use and to suggest measures to change prescribing habits for the better management. Present study was performed with an aim to study the utilization pattern of anti-epileptic drugs (AEDs) for the paediatric patients suffering from various forms of epileptic seizures. Methods: The present cross-sectional study was conducted at the epilepsy clinic of Department of Paediatrics, Tertiary Care Teaching Hospital of Gujarat, on patients diagnosed to have epilepsy July 2014 to October 2014. Hundred Paediatric patients of either gender diagnosed to had epilepsy and taking treatment from pediatric epilepsy clinic OPD, S.S.G. Hospital, and Baroda. Patient's detailed medical history, demographic details and other required information was recorded on a prestructured data entry form. Results: Out of 100. GTCS was found to be the most common (55%) form of epilepsy among pediatric patients and Carbamazepine was the most commonly prescribed (41%) AED followed by sodium valproate (38%). 71% patients were prescribed monotherapy. Carbamazepine +Clobazam was the most commonly (7%) used combination. Conclusions: Use of appropriate AEDs in the majority of patients as per WHO guidelines, has decreased number of ADRs in this study.

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Section: Discussionmentioning

confidence: 99%

Drug utilization pattern of antiepileptic agents among pediatric epilepsy at tertiary care teaching hospital of Gujarat: a cross sectional study

Dave¹,

Trivedi

2018

Int J Basic Clin Pharmacol

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“…Nadkarni et al [8] did not find any significant difference in any parameter of lipid profile with respect to drug administration. Quilan et al [9] showed a significant increase in CAIMT with valproate (MD=0.11,95% CI=0.06-0.15 mm) and Rosmaksoo et al also showed a significant increase in CAIMT with phenytoin with p value of 0.00.…”

Section: Discussionmentioning

confidence: 87%

A Study on the Effect of Antiepileptic Drugs on Serum Lipid Profile and Carotid Artery Intima Media Thickness in Children Between 1 to 12 Years.

et al. 2022

Asian J Pharm Clin Res

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Epilepsy is among the commonly prevalent non communicable disease, particularly related to Central nervous system (CNS). The cumulative lifetime incidence of epilepsy is 3% and more than half of the cases begin in childhood. Seizures are common in pediatric age group and occur in approximately 10% of children. Epilepsyrequires long term anti-convulsanttreatment. The overall aim in the treatment of epilepsy should be complete control of seizures and no adverse reaction due to medication with an optimal quality of life. Epidemiological, clinical and experimental investigations have shown that anti- epileptic drugs (AED) predispose to atherosclerosis by altering the lipid profile.

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“…Epilepsy is the most prevalent neurological condition in children, characterized by a tendency for recurring and unprovoked seizures, and it remains difficult to treat. (6,7). Despite an increase in the number of antiepileptic medications available, more than 25% of children with childhood epilepsy continue to experience seizures.…”

Section: Discussionmentioning

confidence: 99%

A study of Rationale use of Sodium valproate and Levetiracetam as monotherapy in pediatric patients with Epilepsy at tertiary care hospital

Raju

Rajendran

et al. 2022

Biomedicine

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Background: Drug utilization studies helps in the understanding of drug usage among patients, as well as the socioeconomic background and rational use of antiepileptics in children with epilepsy. Objective: The primary aim of this article is to examine the justification for utilizing sodium valproate and Levetiracetam as monotherapy in pediatric epilepsy patients, as well as drug use and prescribing patterns for various kinds of epilepsy. Materials & Methods: Pediatric epilepsy patients under the age of 18 who visited the outpatient department, patients who were on sodium valproate, carbamazepine, or Levetiracetam monotherapy for at least 3 months after starting treatment. Demographic details, disease characteristics like type of epilepsy, onset and duration of episode, details of first attack, last attack, frequency and family history related to epilepsy comorbid conditions. Details on the treatment, such as the drug prescribed, the dose, the duration of the treatment, and the dosage, were noted. Magnetic resonance image (MRI) Brain, CT Brain, Electroencephalogram (EEG) was done in selected patients and noted. Results: In this study we have total of 91 patients younger than 18 years of age confirmed with epilepsy receiving Sodium valproate, Levetiracetam as Monotherapy. Among them 70.3% were male and 29.6% were females. As per the recent Kuppuswamy scale 64.8% of the patients were from an urban background, whereas 35.1% were from a rural background. On analyzing socioeconomic status we found that 38.5% belong to upper middle class family. Nearly 26 % of the patients were diagnosed with focal seizures and 25% with GTCS. Lesser percentage observed with Rolandic, myoclonic, complex partial, refractory epilepsy. Majority 53.8 % were on Sodium valproate among older AEDs. Among newer AEDs 29.6% of patients received Levetiracetam as monotherapy. Key words: Epilepsy, Sodium valproate, Levetiracetam, Monotherapy, Rational use

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Effect of Antiepileptic drugs on lipid profile in children with Epilepsy

Cited by 5 publications

References 13 publications

Drug utilization pattern of antiepileptic agents among pediatric epilepsy at tertiary care teaching hospital of Gujarat: a cross sectional study

Drug utilization pattern of antiepileptic agents among pediatric epilepsy at tertiary care teaching hospital of Gujarat: a cross sectional study

A Study on the Effect of Antiepileptic Drugs on Serum Lipid Profile and Carotid Artery Intima Media Thickness in Children Between 1 to 12 Years.

A study of Rationale use of Sodium valproate and Levetiracetam as monotherapy in pediatric patients with Epilepsy at tertiary care hospital

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