Serum lipidomics analysis of ovariectomized rats under Curcuma comosa treatment

Vinayavekhin, Nawaporn; Sueajai, Jetjamnong; Chaihad, Nichaboon; Panrak, Ratchanee; Chokchaisiri, Ratchanaporn; Sangvanich, Polkit; Suksamrarn, Apichart; Piyachaturawat, Pawinee

doi:10.1016/j.jep.2016.07.054

Cited by 17 publications

(24 citation statements)

References 37 publications

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“…However, in our study two sphingolipid species, CerP (24:0/38:1), were significantly reduced in the osteoporosis group compared with the normal BMD group. Our results contradict a previous animal study of oestrogen loss, where CerP concentrations were upregulated in OVX rats [ 45 ]. Furthermore, in a human study, Lee et al [ 55 ] found that higher sphingosine-1-phosphate (S1P) concentrations were associated with low BMD in menopausal women.…”

Section: Discussioncontrasting

confidence: 99%

“…A previous study reported plasma DG (33:2) decreased with ageing [ 44 ]. Additionally, an animal study reported serum monoacylglycerol and triacylglycerol concentrations decreased in OVX rats as a model of oestrogen deficiency [ 45 ], suggesting that lipid profiles and oestrogen loss upregulate bone-proinflammatory cytokines, which control osteoclast differentiation and promote bone loss.…”

Section: Discussionmentioning

confidence: 99%

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Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

Cabrera

Kruger

Wolber

et al. 2018

IJERPH

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The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model. Plasma concentrations of eight glycerophospholipid, glycerolipid, and sphingolipid species were significantly lower in menopausal women with low BMD but higher in two glycerophospholipid species (phosphatidylinositol and phosphatidic acid). Further, this study found no significant differences in plasma amino acid metabolites. However, trends for lower 4-aminobutyric acid, turanose, proline, aminopropionitrile, threonine, and methionine were found in women with low BMD. This pilot study identified associations between lipid metabolism and femoral neck BMD in SC women. Further studies are required on larger populations for evaluating the bone health effect of these compounds and their usefulness as clinical biomarkers for osteoporosis prediction in women.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

Cabrera

Kruger

Wolber

et al. 2018

IJERPH

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“…Notably, the central action of ceramides can be reversed by decreasing hypothalamic ER stress, resulting in increased BAT thermogenesis and browning of white adipose tissue (WAT), which ultimately ameliorates obesity ( Contreras et al., 2014 , Contreras et al., 2017 ). It also has been reported that peripheral E2 treatment reduces serum ceramide concentration in OVX rats ( Vinayavekhin et al., 2016 ). However, despite this evidence, it is currently unknown (1) whether ovarian estrogens modulate hypothalamic ceramide-induced lipotoxicity, and, more importantly, (2) whether impairment of this mechanism may be the cause of obesity in conditions of estrogen deficiency.…”

Section: Introductionmentioning

confidence: 82%

“…Considering the key role of AMPK on fatty acid metabolism ( Kahn et al., 2005 , Lage et al., 2008 , López et al., 2016 ), this evidence directly links the central effects of estrogens with hypothalamic lipids. However, despite recent data showing sexual dimorphism in brain fatty acid content ( Rodriguez-Navas et al., 2016 ) and even though peripheral E2 treatment reduces serum ceramide levels in OVX rats ( Vinayavekhin et al., 2016 ), whether complex lipids metabolism is involved in the central actions of E2 remains unclear. This is relevant, because the hormonal regulation of lipid metabolism usually shows tissue-specific effects ( López et al., 2010 , Martínez-Sánchez et al., 2017a ).…”

Section: Discussionmentioning

confidence: 99%

“…In this sense, we have recently reported that thyroid hormones (THs) modulate ceramide metabolism in an opposite fashion within different brain areas, such as the hypothalamus and the cerebral cortex ( Martínez-Sánchez et al., 2017a ). Therefore, the fact that systemic E2 decreased serum ceramide levels ( Vinayavekhin et al., 2016 ) did not imply a similar hypothalamic effect.…”

Section: Discussionmentioning

confidence: 99%

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Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

et al. 2018

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SummaryCompelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The anorectic effect of E2 is mainly mediated by its action on the arcuate nucleus (ARC), whereas its effects on brown adipose tissue (BAT) thermogenesis occur in the ventromedial nucleus (VMH). Here, we demonstrate that central E2 decreases hypothalamic ceramide levels and endoplasmic reticulum (ER) stress. Pharmacological or genetic blockade of ceramide synthesis and amelioration of ER stress selectively occurring in the VMH recapitulate the effect of E2, leading to increased BAT thermogenesis, weight loss, and metabolic improvement. These findings demonstrate that E2 regulation of ceramide-induced hypothalamic lipotoxicity and ER stress is an important determinant of energy balance, suggesting that dysregulation of this mechanism may underlie some changes in energy homeostasis seen in females.

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Aspergillus niger upregulated glycerolipid metabolism and ethanol utilization pathway under ethanol stress

et al. 2019

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Organic solvent-tolerant microbes play key roles in many industrial bioprocesses, such as biofuel production, biocatalysis, and bioremediation (Nicolaou, Gaida, & Papoutsakis, 2010). To obtain strains with tolerance to these solvents, an approach involves genetically engineering selected strains based on the knowledge of organic solvent-induced stresses and responses (Taylor, Tuffin, Burton, Eley,

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Serum lipidomics analysis of ovariectomized rats under Curcuma comosa treatment

Cited by 17 publications

References 37 publications

Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

Association of Plasma Lipids and Polar Metabolites with Low Bone Mineral Density in Singaporean-Chinese Menopausal Women: A Pilot Study

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

Aspergillus niger upregulated glycerolipid metabolism and ethanol utilization pathway under ethanol stress

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