Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population

Abstract

Aim: To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population. Methods: Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio. Results: In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03–1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women. Conclusion: Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders.

Association of Albumin to Creatinine Ratio with Cardiovascular Risk Markers and Determination of Their Cut off Points in Type 2 Diabetic Nephropathy Patients

“…In accordance with our results, a significant positive correlation of urine ACR was observed with plasma creatinine, and urine microalbumin in a study of Karar et al [12] In a study population, Zhang et al [17], found positive association of ACR with LDL cholesterol and log of LDL cholesterol/HDL cholesterol ratio in men, in females none of the lipids and lipid related ratios were associated with ACR. Sun et al [18] reported association of ACR with the levels of TGs, HDL cholesterol, Non-HDL cholesterol/HDL cholesterol ratio, TGs/HDL cholesterol ratio, and compared to other lipids and their ratios.…”

Association between Lipid Ratios and Insulin Resistance in a Chinese Population

“…Therefore, using the TG/HDL-C ratio as a surrogate marker of IR has not been widely described in Chinese population. Lipid ratios can also be used to assess the risk of cardiovascular diseases and chronic kidney disease [ 12 , 13 , 14 ].…”

“…TG has been reported to be an alternative surrogate for IR [ 6 ]. Our previous study also indicated that serum TG is a suitable predictor for CKD in men [ 14 ].…”

Metabolic Syndrome and Smoking Are Associated with Future Development of Advanced Chronic Kidney Disease in Older Adults

“…Furthermore, most prior studies investigating the association between CKD and MetS components have been cross-sectional [10,11,12]. In addition, these studies provide results for one or two racial/ethnic groups: Chen et al [13], Hou et al [10], and Zhang et al [11] included only Asians; Kurella et al [9] had a black and white sample. Also, most studies do not encompass the older-age groups: Kurella et al [9] only had middle-aged individuals between the ages of 45 and 64 years, and Kaseda et al [12] only had children between the ages of 1 and 18 years.…”