Association between Lipid Ratios and Insulin Resistance in a Chinese Population

Abstract

AimTo explore the association of lipid ratios and triglyceride (TG) with insulin resistance (IR) in a Chinese population. We also provide the clinical utility of lipid ratios to identify men and women with IR.MethodsThis cross-sectional study included 614 men and 1055 women without diabetes. Insulin resistance was defined by homeostatic model assessment of IR > 2.69. Lipid ratios included the TG/ high density lipoprotein cholesterol (HDL-C), the total cholesterol (TC)/HDL-C and the low density lipoprotein cholesterol (LDL-C)/HDL –C. Logistic regression models and accurate estimates of the area under the receiver operating characteristic (AUROC) curves were obtained.ResultsIn normal-weight men, none of lipid ratios nor TG was associated with IR. In overweight/obese men, normal-weight women and overweight/obese women, the TG/HDL-C, the TC/HDL-C and TG were significantly associated with IR, and the associations were independent of waist circumference. All of the AUROCs for the TG/HDL-C and TG were > 0.7. The AUROCs for TC/HDL-C ratio were 0.69–0.77. The optimal cut-offs for TG/HDL-C were 1.51 in men and 0.84 in women. The optimal cut-offs for TG were 1.78 mmol/L in men and 1.49 mmol/L in women, respectively. In men, the optimal cut-off for LDL-C/HDL-C is 3.80. In women, the optimal cut-off for LDL-C/HDL-C is 3.82.ConclusionThe TG/HDL-C, the TC/HDL-C and TG are associated with IR in overweight/obese men, normal-weight and overweight/obese women. The LDL-C/HDL-C is only associated with IR in normal-weight women. The TG/HDL-C and TG might be used as surrogate markers for assessing IR.

Sex, puberty, and ethnicity have a strong influence on growth and metabolic comorbidities in children and adolescents with obesity: Report on 1300 patients (the Madrid Cohort)

“…Furthermore, insulin resistance induces disturbances in muscle fatty acid handling, and this underlies the associated increase in serum triglycerides and decrease in HDL . Conversely, LDL levels appear to be mainly determined by genetics, with insulin resistance having less influence …”

Optimal cutoff of the triglyceride to high-density lipoprotein cholesterol ratio to detect cardiovascular risk factors among Han adults in Xinjiang

“…According to the ATPIII and JIS criteria, the optimal cutoff for TG/HDL-C was 1.6 and 1.2 in men and 1.1 and 1.1 in women, respectively. The cutoff values of the markers to detect the MetS in Guangdong women is 0.88 [ 30 ] and 0.84 in Zhuhai women [ 31 ]; the cutoff value in Ghanaian women is 0.61 [ 32 ]. In Canada, men and women is 1.62 and 1.18, respectively [ 33 ].…”

Evaluation of Lipid Ratios and Triglyceride-Glucose (TyG) Index as Risk Markers of Insulin Resistance in Iranian Polycystic Ovary Syndrome (PCOS) Woman

“…The positive correlation of TG/HDL-C, TC/HDL-C with HOMA-IR has been demonstrated among PCOS women in China [24] and T2DM in Thailand [26]. Results of some studies also supported that TG/HDL-C ratio could be used as an indicator of IR among some population including the middle-aged and elderly population in Taiwan [16], euthyroid normal-weight healthy adults in Peru [27], PCOS patients in India [28] and in Chinese population without diabetes [29]. A large scale cross-sectional analysis among Chinese adults also indicated that TG/HDL-C ratio and TyG index are useful markers in estimating IR and TyG index is the best indicator for assessing the risk of IR [30].…”