Serum lipid profile of Nigerian diabetics with end stage renal disease

Agaba, Emmanuel I; Duguru, Mary; Agaba, Patricia A; Angbazo, Dorcas

doi:10.4314/wajm.v24i4.28221

Cited by 3 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The logarithm of the ratio is often referred to as atherogenic index. This ratio has been shown in several studies to be a better index for prediction of the risk of coronary artery disease and its attendant morbidity and mortality in both the general population and in patients with CKD 13,27,28. We found significantly higher values in cases compared with controls.…”

Section: Discussionsupporting

confidence: 53%

“…This ratio has been shown in several studies to be a better index for prediction of the risk of coronary artery disease and its attendant morbidity and mortality in both the general population and in patients with CKD. 13 , 27 , 28 We found significantly higher values in cases compared with controls. The atherogenic index found in this study was slightly lower than what was found by previous researchers.…”

Section: Discussionmentioning

confidence: 44%

“…Apart from being a strong cardiovascular risk factor for coronary heart disease, because of its strong atherogenic profile, LDL-C also contributes adversely to progression of renal disease 9,24. It does this by inducing the formation of oxygen radicals in arteries, in glomeruli and in juxtaglomerular cells, which results in an inhibition of nitric oxide-mediated vasodilatation, stimulation of renin release and modulation of mesangial cell growth and apoptosis 25,26,27…”

Section: Discussionmentioning

confidence: 99%

“… 9 , 24 It does this by inducing the formation of oxygen radicals in arteries, in glomeruli and in juxtaglomerular cells, which results in an inhibition of nitric oxide-mediated vasodilatation, stimulation of renin release and modulation of mesangial cell growth and apoptosis. 25 , 26 , 27 …”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Assessment of dyslipidemia in pre-dialysis patients in south-west Nigeria

et al. 2014

View full text Add to dashboard Cite

Background:Majority of chronic kidney disease (CKD) patients are more likely to die of cardiovascular complications before reaching end stage renal disease. The Kidney Disease Outcomes Quality Initiative (K/DOQI) recommends that all CKD patients should be evaluated for dyslipidemia and for treatment to reduce the risk of cardiovascular events.Patients and Methods:A cross-sectional case control study to determine the frequency of occurrence of lipid abnormalities in patients with CKD and compare these abnormalities with that of normal controls. A total of 100 patients and 100 controls were recruited for the study. Demographic and clinical data were obtained using structured questionnaire. Weight, height and waist circumference, body mass index (BMI) and blood pressure were also obtained. Subjects had their fasting lipid profile and fasting plasma glucose assayed after overnight fast of 8-14 hours. Low-density lipoprotein (LDL) was obtained using Friedwald formula.Result:The study revealed that total cholesterol (TC) was elevated above normal levels in 44% of cases compared with 6% in controls (P < 0.001), with the mean (SD) value of 5.82 ± 3.28 mmol/l for cases compared with 3.9 ± 1.0 mmol/l (P < 0.001) in controls. Low density lipoprotein was elevated in 48% of cases compared with 14% in controls (P < 0.001), with the mean (SD) values of 4.15 ± 2.74 mmol/l and 2.57 ± 0.95 mmol/l for cases and controls, respectively, (P < 0.001). Triglyceride (TG) was elevated above normal level in 26% of cases compared with none in the controls (P < 0.001), with the mean (SD) values of 1.41 ± 1.10 mmol/l and 0.64 ± 0.24 mmol/l for cases and controls, respectively (P < 0.001). All Lipid fractions except HDL also correlated significantly with levels of proteinuria TC (r = 0.345, P = 0.001), TG (r = 0.268, P = 0.011) LDL (r = 0.366, P = 0.001).Conclusion:Dyslipidemia is common among patients with CKD. Regular evaluation of all CKD patients for dyslipidemia and treatment need be instituted.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of dyslipidemia in pre-dialysis patients in south-west Nigeria

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Misuse of OTC drugs is understudied in sub-Saharan Africa despite risks that may be associated with harms including addiction, drug resistance and masking underlying symptoms of an illness [ 2 , 11 , 66 ]. A global systematic review [ 22 ], which included only two studies from Africa [ 49 , 67 ], noted that OTC drugs were misused. More studies need to be conducted to understand the misuse of OTC analgesics to ensure that they are used responsibly, as advocated for by the World Health Organisation [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Knowledge, use (misuse) and perceptions of over-the-counter analgesics in sub-Saharan Africa: a scoping review

Kawuma

Chimukuche

Francis

et al. 2021

Global Health Action

View full text Add to dashboard Cite

Background Over-the-counter (OTC) analgesics are safe for pain-management when used as recommended. Misuse can increase the risk of hypertension and gastrointestinal problems. Objective To conduct a scoping review of the uses and misuses of OTC analgesics in sub-Saharan Africa, to inform strategies for correct use. Method Following guidelines for conducting a scoping review, we systematically searched Pubmed, ResearchGate and Google Scholar databases for published articles on OTC analgesic drug use in sub-Saharan Africa, without restrictions on publication year or language. Search terms were ‘analgesics’, ‘non-prescription drugs’, ‘use or dependence or patterns or misuse or abuse’ and ‘sub-Saharan Africa’. Articles focusing on prescription drugs were excluded. Results Of 1381 articles identified, 35 papers from 13 countries were eligible for inclusion. Most were quantitative cross-sectional studies, two were mixed-methods studies, and one used qualitative methods only. About half ( n = 17) the studies recorded prevalence of OTC drug use above 70%, including non-analgesics. Headache and fever were the most common ailments for which OTC drugs were taken. Primary sources of OTC drugs were pharmacy and drug shops, and family, friends and relatives as well as leftover drugs from previous treatment. The main reasons for OTC drug use were challenges in health service access, perception of illness as minor, and knowledge gained from treating a previous illness. Information regarding self-medication came from family, friends and neighbours, pharmacies and reading leaflets either distributed in the community or at institutions of learning. OTC drug use tended to be more commonly reported among females, those with an education lower than secondary level, and participants aged ≥50 years. Conclusion Self-medicating with OTC drugs including analgesics is prevalent in sub-Saharan Africa. However, literature on reasons for this, and misuse, is limited. Research is needed to educate providers and the public on safe use of OTC drugs.

show abstract

Risk factors for Undiagnosed Kidney Disease among Stable First-Degree Relatives of Chronic Kidney Disease Patients at Nnamdi Azikiwe University Teaching Hospital, Nnewi, South Eastern Nigeria

Ozuemba,

Ezeude,

Odenigbo

et al. 2024

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Background: Chronic kidney disease (CKD) is a global public health problem and has a major impact on health and cost of health care. In Nigeria, renal replacement therapy (RRT) is funded out of pockets by patients and their relatives unlike in most developed countries. There is a high clustering of the risk factors for CKD in FDRs of CKD patients, making then an ideal population for the screening for and the reversal of the modifiable risk factors that predispose to CKD. Objective: This study determined the risk factors for CKD in the FDRs of patients Methodology: This study involving 300 subjects: 150 FDRs of CKD patients and 150 control subjects without personal or family history of CKD. The study and control subjects were screened for CKD using urine albumin creatinine ratio (uACR) and estimated glomerular filtration rate (eGFR). Prevalence rate of the risk factors for CKD such as hypertension, diabetes mellitus, obesity, dyslipidaemia, hyperuricaemia and life style practices like significant smoking and heavy alcohol consumption were determined for both the FDRs and the control subjects. Data was analyzed with SPSS version 21.0. Mann-Whitney U test was used for comparing the variables between the two study groups for continuous variables that were not normally distributed and Chi square tests for categorical variables. Results: The prevalence rate of dyslipidaemia and hyperuricaemia was significantly higher among the FDRs of CKD patients compared with the control subjects (26% versus 12%; P = 0.003) and (20.7% versus 7.3%; P = 0.001) respectively. The other risk factors for CKD that included hypertension, diabetes mellitus, obesity, significant cigarette smoking, heavy alcohol consumption and herbal medication use were equally more among the FDRs of CKD patients compared with the controls, although not statistically significant. Conclusion: The risk factors for CKD were common among FDRs of CKD patients. Screening for these risk factors at the earliest possible contact with the FDRs of CKD patients and taking appropriate actions to tackle the modifiable ones will prevent the development of CKD and retard the progression of the already existing disease, reduce the alarming global burden of CKD.

show abstract

Serum lipid profile of Nigerian diabetics with end stage renal disease

Cited by 3 publications

References 0 publications

Assessment of dyslipidemia in pre-dialysis patients in south-west Nigeria

Assessment of dyslipidemia in pre-dialysis patients in south-west Nigeria

Knowledge, use (misuse) and perceptions of over-the-counter analgesics in sub-Saharan Africa: a scoping review

Risk factors for Undiagnosed Kidney Disease among Stable First-Degree Relatives of Chronic Kidney Disease Patients at Nnamdi Azikiwe University Teaching Hospital, Nnewi, South Eastern Nigeria

Contact Info

Product

Resources

About