Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis

Villani, Rosanna; Cosimo, Francesca Di; Romano, Antonino Davide; Sangineto, Moris; Serviddio, Gaetano

doi:10.1038/s41598-021-93251-3

Cited by 21 publications

(28 citation statements)

References 34 publications

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“…Recent studies among predominantly genotype 1 HCV-infected patients suggest an effect of DAAs therapy on cholesterol and triglyceride levels [48,49]. Thus, DAAs therapy induce elevated triglycerides and cholesterol levels [50,51]. In line with these reports, we observed a significant increase in triglyceride levels (124.03 ± 113.49 mg/dL vs. 153.78 ± 94.53 mg/dL) and in cholesterol levels (191.61 ± 67.19 mg/dL vs. 216.52 ± 50.85), respectively.…”

Section: Discussionmentioning

confidence: 99%

Changes in Liver Steatosis Using Controlled Attenuation Parameter among Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals Therapy Who Achieved Sustained Virological Response

et al. 2022

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Chronic hepatitis C virus (HCV) infection induces hepatic steatosis due to viral and host factors. However, information regarding the effects of direct-acting antivirals (DAAs) therapy on liver steatosis and fibrosis is limited. Vibration-controlled transient elastography (VCTE) with a controlled attenuation parameter (CAP) represents a non-invasive method, which has been used in the last few years for the detection of hepatic steatosis and fibrosis before and at a sustained virological response at 12 weeks (SVR12). The aim of this study was to assess the modifications of liver steatosis and fibrosis in HCV-infected patients who achieved SVR12. Consecutive patients with chronic HCV infection that were treated with DAAs in a tertiary gastroenterology center from Romania were included. Demographics, laboratory data, and VCTE evaluation were recorded in all patients. Patients with previous hepatic decompensation and those who did not achieve SVR were excluded. Two hundred and eighty patients (67.1% females) who achieved SVR12 were included. Regarding the changes in biological parameters, including liver enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), reduced to normal levels at SVR12 compared to the baseline (28.72 ± 24.71 U/L vs. 40.72 ± 27.34 U/L for ALT, p < 0.013 and 27.21 ± 11.15 U/L vs. 33.35 ± 23.37 U/L for AST, p = 0.029). On the contrary, the levels of triglycerides increased significantly from the baseline to SVR12 (124.03 ± 113.49 mg/dL to 153.78 ± 94.53, p = 0.004). Regarding hepatic steatosis by CAP evaluation, at SVR12, 186 (66.4%) of the individuals had a CAP score of ≥248 dB/m, an increase of 4.6% from the baseline. After viral eradication with DAAs, we observed an increase in hepatic steatosis. Hence, a long-term follow-up is mandatory to identify HCV-infected patients with hepatic steatosis post-SVR and the risk factors for more severe outcomes.

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Section: Discussionmentioning

confidence: 99%

Changes in Liver Steatosis Using Controlled Attenuation Parameter among Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals Therapy Who Achieved Sustained Virological Response

et al. 2022

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“…Unexpectedly, DAA therapy did not significantly influence serum TG levels [ 3 ]. Similarly, serum TG levels were comparable between HCV-infected patients and noninfected controls [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Sex-specific changes in triglyceride profiles in liver cirrhosis and hepatitis C virus infection

et al. 2022

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Background Hepatitis C virus (HCV) infection is associated with serum lipid abnormalities, which partly normalize following direct-acting antiviral (DAA) therapy. Here, associations of serum triglycerides (TGs) with viral genotype and markers of liver disease severity were evaluated in patients with chronic HCV. Methods The study included the serum of 177 patients with chronic HCV. TGs were quantified by flow injection analysis Fourier transform mass spectrometry. Laboratory values and noninvasive scores for liver fibrosis assessment were determined. The nonparametric Kruskal‒Wallis test, one-way ANOVA, multiple linear regression and Student’s t test were used as appropriate. P values were adjusted for multiple comparisons. Results HCV-infected women had lower serum TGs than men, and thus, a sex-specific analysis was performed. None of the 46 TG species analyzed differed in the serum of female patients with and without liver cirrhosis. In contrast, in the serum of male patients with liver cirrhosis, TGs with 53, 56 and 58 carbon atoms and three to eight double bonds were diminished. These polyunsaturated TGs were also low in males with a high fibrosis-4 score. TGs with 7 or 8 double bonds negatively correlated with the model of end-stage liver disease score in males. In addition, TGs with 49, 51 and 53 carbon atoms were reduced in male patients infected with genotype 3a in comparison to genotype 1a. TGs with 56 carbon atoms were lower in genotype 3a-infected males than in genotype 1b-infected males. TGs did not differ in females by genotype. Genotype 3-related changes disappeared at the end of therapy with DAAs. Overall, the levels of serum TGs did not change during DAA therapy in either sex. Consequently, the serum TGs of males with liver cirrhosis were lower than those of males without cirrhosis at the end of therapy. Such a difference was not apparent in females. Conclusions The decline in TGs observed only in male patients with liver cirrhosis and male patients infected with genotype 3 illustrates sex-specific changes in lipid metabolism in chronic HCV.

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“… 4 On the contrary, other studies showed no effect of directly acting antiviral (DAA) therapy on triglyceride levels. 5 …”

Section: Discussionmentioning

confidence: 99%

COVID‐19 treatment: A potential cause of acute pancreatitis

Allam

El‐Zawawy

Ahmed

et al. 2022

Clinical Case Reports

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Serum lipid profile in HCV patients treated with direct-acting antivirals: a systematic review and meta-analysis

Cited by 21 publications

References 34 publications

Changes in Liver Steatosis Using Controlled Attenuation Parameter among Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals Therapy Who Achieved Sustained Virological Response

Changes in Liver Steatosis Using Controlled Attenuation Parameter among Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals Therapy Who Achieved Sustained Virological Response

Sex-specific changes in triglyceride profiles in liver cirrhosis and hepatitis C virus infection

COVID‐19 treatment: A potential cause of acute pancreatitis

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