Serum lipid profile changes during the menopausal transition in Chinese women

Zhou, Jinling; Lin, Shunquan; Shen, Ying; Chen, Ying; Zhang, Ying; Chen, Fengling

doi:10.1097/gme.0b013e3181dbdc30

Cited by 42 publications

(33 citation statements)

References 31 publications

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“…LDL-C is a major cause of CHD, as well as the primary target of lipid-lowering therapy 26 . BMI has been found to be related to TC 8,9 and LDL-C 8 concentrations in BCS, similar to findings in non-BCS 6 . A study of 104 Brazilian postmenopausal BCS found that the rates of high TC and high LDL-C were 56.7 and 83.4%, respectively 31 .…”

Section: Discussionsupporting

confidence: 66%

“…A study of 104 Brazilian postmenopausal BCS found that the rates of high TC and high LDL-C were 56.7 and 83.4%, respectively 31 . Moreover, a prospective study of non-BCS found that the menopause transition was associated with significant increases in TC and TG concentrations 6 . The Study of Women's Health Across the Nation (SWAN) found that TC, LDL-C and TG levels peaked during late perimenopause and early postmenopause 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have identified the high prevalence of CVD risk factors in middle-aged women 3,4 . Elevated serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were described in perimenopausal women 5,6 . The behavior of high-density lipoprotein cholesterol (HDL-C) levels in the menopause transition is less clear and reports have described that HDL-C concentration is not correlated with menopause status 6 .…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models

Sousa-e-Silva¹,

Conde²,

Martinez³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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PURPOSE: It was to assess the risk of cardiovascular disease (CVD) in breast cancer survivors (BCS). METHODS:This cross-sectional study analyzed 67 BCS, aged 45-65 years, who underwent complete oncological treatment, but had not received hormone therapy, tamoxifen or aromatase inhibitors during the previous 6 months. Lipid profile and CVD risk were evaluated, the latter using the Framingham and Systematic COronary Risk Evaluation (SCORE) models. The agreement between cardiovascular risk models was analyzed by calculating a kappa coefficient and its 95% confidence interval (CI). RESULTS: Mean subject age was 53.2±6.0 years, with rates of obesity, hypertension, and dyslipidemia of 25, 34 and 90%, respectively. The most frequent lipid abnormalities were high total cholesterol (70%), high LDL-C (51%) and high non-HDL-C (48%) concentrations. Based on the Framingham score, 22% of the participants had a high risk for coronary artery disease. According to the SCORE model, 100 and 93% of the participants were at low risk for fatal CVD in populations at low and high risk, respectively, for CVD. The agreement between the Framingham and SCORE risk models was poor (kappa: 0.1; 95%CI 0.01-0.2) for populations at high risk for CVD. CONCLUSIONS: These findings indicate the need to include lipid profile and CVD risk assessment in the follow-up of BCS, focusing on adequate control of serum lipid concentrations. ResumoOBJETIVO: Avaliar o risco de doença cardiovascular (DCV) em mulheres com câncer de mama. MÉTODOS: Foi conduzido estudo de corte transversal, com 67 mulheres com câncer de mama, entre 45 e 65 anos, tratamento oncológico completo, não usuárias de terapia hormonal, tamoxifeno ou inibidores da aromatase nos últimos 6 meses. Foram avaliados o perfil lipídico e o risco de DCV. Para avaliar o risco de DCV, foram utilizados os modelos Framingham e Systematic COronary Risk Evaluation (SCORE). Para investigar a concordância entre os modelos de risco cardiovascular, foi calculado o coeficiente kappa com seu respectivo intervalo de confiança (IC) de 95%. RESULTADOS: A média de idade das participantes foi de 53,2±6,0 anos. A prevalência de obesidade, hipertensão e dislipidemia foi 25, 34 e 90%, respectivamente. A prevalência de dislipidemia foi 90%. As anormalidades mais comuns do perfil lipídico foram: alto colesterol total (70%), alto LDL-C (51%) e alto não HDL-C (48%). Baseado no escore de Framingham, 22% das mulheres com câncer de mama apresentaram alto risco de doença arterial coronariana. De acordo com o modelo SCORE, 100 e 93% das participantes apresentaram baixo risco de DCV fatal, considerando populações de baixo e alto risco de DCV, respectivamente. A concordância entre os modelos de Framingham e SCORE foi ruim (kappa: 0,1; IC95% 0,01-0,2), considerando populações de alto risco de DCV. CONCLUSÕES: Esses dados indicam a necessidade de incluir a avaliação do perfil lipídico e do risco de DCV na rotina de seguimento de mulheres com câncer de mama, sendo observadoo adequado controle dos níveis séricos de lipídios.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models

Sousa-e-Silva¹,

Conde²,

Martinez³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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“…However, a Chinese study reported different results showing that only late perimenopausal status was associated with lipid abnormalities [6]. In that study, women in late perimenopause (2-12 months of amenorrhea once during a year) had significantly higher levels of TC, TG, and TC/HDL-C ratios compared with women in pre-menopause independent of age, BMI, and other confounding factors, while LDL-C levels were not significantly elevated; however, there were no significant changes in HDL-C with menopausal stages [6]. There have been inconsistent results with regard to TG changes during menopause.…”

Section: Discussionmentioning

confidence: 91%

“…Epidemiological studies found greater levels of total cholesterol (TC), low density lipoproteincholesterol (LDL-C), triglycerides (TG), and apolipoprotein B (Apo B) in post-menopausal compared to pre-menopausal women; inconsistent results were found for HDL cholesterol (HDL-C) [3,4]. Other studies reported that the perimenopausal period was associated with elevated total cholesterol, LDL-C, TG, and TC/HDL-C ratio [5,6] and that the greatest increase in HDL-C level was observed in late perimenopause and early post-menopause [5].…”

Section: Introductionmentioning

confidence: 95%

Menopausal stages and serum lipid and lipoprotein abnormalities in middle-aged women

et al. 2015

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Association between HDL-C levels and menopause: a meta-analysis

Sun

Chen

et al. 2020

Hormones

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Purpose Menopause modifies women’s lipid profiles. However, the fact that it is still unclear whether high-density lipoprotein-cholesterol (HDL-C) levels decrease in postmenopausal women necessitated a systematic review and meta-analysis. Methods The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched and 498 articles published between 1987 and 2020 were retrieved. Studies reporting HDL-C, low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels in both postmenopausal and premenopausal populations were included. The quality of the included studies was assessed using the Cross-Sectional/Prevalence Study Quality tool. The standard mean difference (SMD) and 95% confidence interval (CI) were estimated using random effects models. A meta-regression analysis and subgroup analysis were performed to identify potential modifiers. Egger’s test and funnel plots were constructed to evaluate publication biases. Results Lipid profiles from 18 cross-sectional studies and two cohort studies including 5652 postmenopausal women and 7825 premenopausal women were meta-analyzed. HDL-C levels were not significantly different between the postmenopausal and premenopausal women (SMD = − 0.053, 95% CI − 0.171 to 0.066, p = 0.383) and were not affected by country, publication year, study quality in the meta-regression analysis, or significant publication bias. Higher LDL-C, TC, and TG levels were detected in postmenopausal women than in premenopausal controls. Conclusion Unlike increased LDL-C, TC, and TG levels, HDL-C levels in pre- and postmenopausal women were not different in this first meta-analysis of lipid profiles in premenopausal and postmenopausal women. Prospective studies with large populations examining HDL-C levels and functions in women with different menopausal statuses are essential in the future. Trial registration number None.

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Serum lipid profile changes during the menopausal transition in Chinese women

Cited by 42 publications

References 31 publications

Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models

Cardiovascular risk in middle-aged breast cancer survivors: a comparison between two risk models

Menopausal stages and serum lipid and lipoprotein abnormalities in middle-aged women

Association between HDL-C levels and menopause: a meta-analysis

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