Serum lipid growth curves for children and adolescents in predicting adult dyslipidemia (Data from the Slovak Lipid Community Study)

Background:Lipid imbalance when diagnosed in childhood, can forecast the development of atherosclerosis in adulthood and its complications. Therefore, early detection of dyslipidemia should begin in childhood and it should lead to long-term prevention of atherosclerosis by controlling the risk factors. The Objectives of the study were to study lipid profile of children in the age group of 10-19 years and the prevalence of dyslipidemia among them.Methods: This is a cross-sectional study, which was conducted in 300 children aged 10 to 19 years, of either sex, from schools of Barabanki. After getting consent from school authorities, children and their parents, a detailed history was taken with a pre-designed pro forma and fasting blood samples were analyzed for lipid profile.Results:Mean total cholesterol (TC) for boys and girls were 161.06±33.14 mg/dl and 164.68±33.53 mg/dl, LDL-C 99.35±27.41 mg/dl and 101.71±26.44 mg/dl, HDL-C 42.76±5.78 mg/dl and 43.93±5.68 mg/dl, VLDL-C 18.94±4.47 mg/dl and 19.04±4.97 mg/dl and triglycerides (TG) 94.69±22.34 mg/dl and 95.20±24.83 mg/dl respectively. Serum TC, TG, LDL-C, VLDL-C and HDL-C levels were higher in girls than in boys for all age groups. 26.55% boys and 25.20% girls had TC levels above 190 mg/dl. The overall results revealed that 26.0% of children had hypercholesterolemia.Conclusions:The study presents age- and sex-related findings about the dynamics of changes in serum lipid levels in children. Significant number of children had hypercholesterolemia.

Section: Discussionsupporting

confidence: 48%

“…26 While in Slovak study, about 19% of boys and 25% of girls had borderline elevated and 6% of boys and 15% of girls had elevated TC. 29 In the present study, to determine the prevalence of hypercholesterolemia the cut-off point was taken as above 190 mg/dl of TC. 8 26.55% boys and 25.20% girls had TC levels above 190mg/dl.…”

Section: Discussionmentioning

confidence: 99%

Lipid profile in school children: study from a District of Uttar Pradesh, India

Bansal

Rathoria

Gupta

et al. 2017

“…Low Density Lipoprotein Cholesterol (LDL-C) was estimated by Friedewald formula. 13 Insulin measurement was done by using solid phase chemiluminescence immunoassay.…”

Section: Exclusion Criteriamentioning

confidence: 99%

Correlation of serum leptin levels with clinical and biochemical parameters in obese children

Patil

Srinivas

2020

Background: Leptin plays a crucial role in the regulation of appetite, glucose homeostasis and body fat. Authors described various clinical and biochemical parameters of obese children aged 6 to 18 years visiting to outpatient department in a tertiary care hospital followed by their correlation with serum leptin levels. It was a prospective observational study.Methods: Obese children with Body Mass Index >2 standard deviation according to WHO chart were included. Endocrinological and syndromic obese children were excluded. Authors first compared leptin level of obese children with age and sex matched nonobese children. Followed by correlation of serum leptin levels with various clinical and laboratory parameters in obese children. Pearson’s correlation coefficient was used to compute the strength of relationship of leptin with various quantitative parameters. Mann-Whitney Test was also used when standard deviation was high, to calculate statistical significance.Results: Leptin concentration was significantly higher in obese children than non-obese. No significant difference in sex distribution was found. Serum leptin levels showed positive correlation with BMI, skin fold thickness and abdominal circumference, and blood pressure. No statistical correlation of leptin with biochemical parameters such as dyslipidemia, fasting blood glucose and insulin resistance was seen.Conclusions: In this study though serum leptin levels had a positive correlation with various clinical parameters, but no statistically significant correlation was seen with biochemical parameters. There is need for further investigation with a larger sample size on the role of leptin in childhood obesity.,

“…Low density lipoprotein cholesterol (LDL-C) was estimated by Friedewald formula. 8 Insulin measurement was done by using solid phase chemiluminescence immunoassay.…”

Section: Exclusion Criteriamentioning

confidence: 99%

Comparison of clinical and biochemical profile of obese and nonobese children

Patil

Srinivas²

2018

Background: We compared clinical and biochemical parameters of obese children aged 6 to 18 years with normal controls visiting to outpatient department in a tertiary care hospital. It was a prospective case control study.Methods: Obese children with Body Mass Index > 2 standard deviation according to WHO chart were included. Endocrinological and syndromic obese children were excluded. We described risk factors for obesity and compared clinical and biochemical parameters between cases and controls. Student’s t test, Chi-square test and ANOVA (analysis of variance) were used for statistical analysis.Results: We noted higher prevalence of intake of junk food and sedentary lifestyle in obese group. Anthropometric parameters including BMI, skin fold thickness and abdominal circumference were higher in obese children compared to control group. Both systolic and diastolic blood pressures were high in obese children compared to control group. We observed higher prevalence of insulin resistance and dyslipidaemia among obese children.Conclusions: This study reemphasises that junk foods and sedentary lifestyle are important risk factors for obesity. Always screen for glucose intolerance, hypertension, insulin resistance and dyslipidaemia in obese children.