Serum levels of YKL-40 and interleukin-18 and their relationship to disease severity in patients with preeclampsia

Seol, Hyun Joo; Lee, Eun Sung; Jung, So Eun; Jeong, Nan Hee; Lim, Ji Eun; Park, Sunghoon; Hong, Soon Cheol; Oh, Min Jeong; Kim, Hai Joong

doi:10.1016/j.jri.2008.10.003

Cited by 23 publications

(30 citation statements)

References 19 publications

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“…IL-6) and vasoactive markers (Lamarca, 2010). In preeclampsia plasma YKL-40 are elevated when compared to healthy controls (Seol et al, 2009). However, the women diagnosed with GDM in the present study were not affected by preeclampsia (and no description of this was reported by Schaller et al (Schaller et al, 2010)), and this emphasises a marked difference between GDM and preeclampsia with regard to YKL-40 levels.…”

Section: Discussioncontrasting

confidence: 73%

Plasma YKL-40 during pregnancy and gestational diabetes mellitus

Nielsen

Rathcke

Bonde

et al. 2015

Journal of Reproductive Immunology

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Section: Discussioncontrasting

confidence: 73%

Plasma YKL-40 during pregnancy and gestational diabetes mellitus

Nielsen

Rathcke

Bonde

et al. 2015

Journal of Reproductive Immunology

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“…However, only a few studies have associated il-18 to preeclampsia. Two studies have described a significant elevation of serum and/or placenta IL-18 levels in preeclampsia (16,17). others have examined the level of il-18 in preeclamptic plasma (18,19).…”

Section: Discussionmentioning

confidence: 99%

“…il-18 plays an important role in the Th1-mediated immune response in conjunction with interleukin-12 (il-12), and also stimulates the Th2 immune response in the absence of il-12 (15). To date, il-18 levels in preeclampsia have been measured in only a few studies, which reported contradictory results in the sera (16,17) and plasma (18,19) of normotensive and pre eclamptic women. notably, not only iFn-γ, which is induced by il-18, but also il-18 itself proved to be independently capable of inducing ido expression (20).…”

Section: Introductionmentioning

confidence: 99%

Reduced expression of indoleamine 2,3-dioxygenase participates in pathogenesis of preeclampsia via regulatory T cells

Liu

Ding

et al. 2010

Mol Med Rep

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Abstract. Preeclampsia is a complex multi-organ disease and the leading cause of maternofetal morbidity and mortality. low levels of indoleamine 2,3-dioxygenase (ido) and diminished numbers of regulatory T cells (Tregs) have been separately reported to participate in the pathogenesis of preeclampsia. in the present study, we aimed to determine whether alterations in the expression of ido, forkhead box P3 (Foxp3) and interleukin-18 (il-18) contribute to the pathogenesis of preeclampsia, by measuring their levels in preeclamptic placentae and in placentae from healthy pregnant women as a control. ido protein levels were determined by immunohistochemistry, while the mrna levels of ido, FoxP3 and il-18 were measured by quantitative rT-Pcr. The intensity of ido immunostaining was lower in the preeclamptic placentae than in the normal controls, and was related to the clinical severity of the preeclampsia. Quantitative rT-Pcr revealed that the ido and il-18 mrna levels were reduced in a correlated manner the preeclamptic placentae compared to the controls, and that the levels of FoxP3 mrna were consistently decreased in the preeclamptic group. a positive correlation betwen FoxP3 and ido mrna was found. The results of the study indicate that il-18, ido and FoxP3 mrna levels were decreased in the preeclamptic placentae. reduced ido levels in pre eclampsia may be partly influenced by IL-18, and result in the maladaptation of maternal tolerance and the pathogenesis of preeclampsia by directly reducing Tregs.

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“…15,16,22,23 However, four studies only provided values of median and range. 14,[24][25][26] In these cases, the mean and S.D. were estimated using the recommendations of Hozo et al 27 One article reported the plasma levels of IL-18 as mean and standard error (S.E.).…”

Section: Data Extractionmentioning

confidence: 99%