Serum levels of vitamin D in patients with recurrent aphthous stomatitis

Zakeri, Masume; Parsian, Hadi; Bijani, Ali; Shirzad, Atena; Neamati, Nahid

doi:10.17219/dmp/126360

Cited by 6 publications

(12 citation statements)

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“…The VDR is activated by binding to calcitriol (1,25(OH) 2 D 3 ) and subsequently transforms into heterodimer with retinoid receptor X (RXR). The calcitriol-VDR-RXR complex binds to the specific gene promoter region of the DNA and therefore is able to either promote or inhibit the RNA polymerase II specific VDR-dependent genes [ 10 ]. Figure 3 presents the classic vitamin D 3 pathway on the basis of the literature [ 38 ].…”

Section: Vitamin D 3 Receptor and Mechanisms Of Ac...mentioning

confidence: 99%

“…Additionally, vitamin D 3 decreases maturation and proliferation of B lymphocytes. Therefore, secretion of immunoglobulins IgG and IgM is limited [ 10 , 63 ].…”

Section: Role Of Vitamin D 3 In Autoimmune Thyroid...mentioning

confidence: 99%

“…Vitamin D 3 is in great interest of many different specialties, including among others endocrinology, and dentistry. Low levels of vitamin D 3 have been linked with the presence of recurrent aphthous stomatitis [ 10 ] and may increase in the risk of the development of periodontal disease [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D3 Metabolism and Its Role in Temporomandibular Joint Osteoarthritis and Autoimmune Thyroid Diseases

Szulc

Świątkowska−Stodulska

Pawłowska

et al. 2023

IJMS

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The aim of this review was to present the metabolism of vitamin D3, as well as to discuss the role of vitamin D3 in bone metabolism, temporomandibular joint osteoarthritis (TMJ OA), and autoimmune thyroid diseases (AITD) on the basis of the literature. Vitamin D3 plays a significant role in human health, as it affects the calcium-phosphate balance and regulates the bone metabolism. Calcitriol impresses the pleiotropic effect on human biology and metabolism. Its modulative function upon the immune system is based on the reduction of Th1 cell activity and increased immunotolerance. Vitamin D3 deficiency may lead to an imbalance in the relationship between Th1/Th17 and Th2, Th17/Th reg, and is considered by some authors as one of the possible backgrounds of autoimmune thyroid diseases (AITD), e.g., Hashimoto’s thyroiditis or Graves’ disease. Moreover, vitamin D3, through its direct and indirect influence on bones and joints, may also play an important role in the development and progression of degenerative joint diseases, including temporomandibular joint osteoarthritis. Further randomized, double blind studies are needed to unequivocally confirm the relationship between vitamin D3 and abovementioned diseases and to answer the question concerning whether vitamin D3 supplementation may be used in the prevention and/or treatment of either AITD or OA diseases.

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Section: Vitamin D 3 Receptor and Mechanisms Of Ac...mentioning

confidence: 99%

“…Additionally, vitamin D 3 decreases maturation and proliferation of B lymphocytes. Therefore, secretion of immunoglobulins IgG and IgM is limited [ 10 , 63 ].…”

Section: Role Of Vitamin D 3 In Autoimmune Thyroid...mentioning

confidence: 99%

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Vitamin D3 Metabolism and Its Role in Temporomandibular Joint Osteoarthritis and Autoimmune Thyroid Diseases

Szulc

Świątkowska−Stodulska

Pawłowska

et al. 2023

IJMS

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“…According to a few studies [18,22,23,35], in patients with recurrent aphthous stomatitis, the level of serum 25(OH)D is significantly lower than in healthy people of similar ages and genders. Thus, Ainure Oztekin and Joshkun Oztekin [18] recommend vitamin D supplementation as a supportive treatment in patients with recurrent aphthous stomatitis.…”

Section: Recurrent Aphthous Stomatitis (Ras)mentioning

confidence: 99%

Vitamin D and Its Role in Oral Diseases Development. Scoping Review

et al. 2021

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Vitamin D is a fat-soluble secosteroid that plays a significant role in the whole body, including the maxillofacial region. The discovery of its receptors in many cells and organs made it possible to reveal the participation of vitamin D not only in the regulation of calcium phosphate metabolism, but also in immune processes, in providing anti-inflammatory and antimicrobial effects, slowing down cell proliferation and stimulating differentiation. In this literature review, we demonstrate the association between low vitamin D levels and the development of recurrent aphthous stomatitis, the course and response to treatment of squamous cell carcinoma of the oral cavity, the severity of periodontal diseases, and the processes of osseointegration and bone remodeling during dental implantation and guided tissue regeneration. The aim of our article was to demonstate a possible connection between vitamin D level and the oral diseases that can be presented at an oral surgery appointment, which will help clinicians to reduce the risk of early dental implant failure, ensure favorable outcomes of augmentative operations, as well as decrease the destructive effects of severe periodontitis and other conditions throug knowledge and timely lab tests and endocrinologist prescriptions.

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“…[ 8 ] To attain such objectives, different topically and systemically applied medications have been used such as corticosteroids, anti-inflammatories, immunomodulatories, and antiseptic medications. [ 9 ] Immunomodulating agents modulate and enhance T-cell-mediated immunity, restore the phagocytic activity of regular macrophages and neutrophils, and potentiate human interferon and interleukin-2 activity. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%