Serum levels of thiobarbituric acid reactive substances predict cardiovascular events in patients with stable coronary artery disease

Walter, Mary; Jacob, Robert F.; Jeffers, Barrett W.; Ghadanfar, Mathieu; Preston, Gregory M.; Buch, J; Mason, R. Preston

doi:10.1016/j.jacc.2004.08.029

Cited by 182 publications

(155 citation statements)

References 43 publications

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“…Walter and colleagues demonstrated that serum oxidative stress markers such as thiobarbituric acidreactive substances are predictive of cardiovascular events including fatal and nonfatal myocardial infarction. (21) Oxidative stress is also associated with a faster bone turnover, higher bone resorption, and osteoporosis because oxidative stress inhibits osteoblastogenesis. (22) Recently, a study demonstrated that oxidative stress was increased in older patients with hip fracture compared with healthy elderly controls.…”

Section: Discussionmentioning

confidence: 99%

Hip fracture and risk of acute myocardial infarction: A nationwide study

Chiang

Liu

Chen

et al. 2012

Journal of Bone and Mineral Research

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Osteoporotic fractures are associated with increased mortality risk. However, little data are available on the risk of acute myocardial infarction (AMI) after hip fracture. Therefore, we investigated whether hip fracture increased the risk of AMI in a large, nationwide cohort study. We obtained data from 8758 patients diagnosed with hip fracture from 2000 to 2009 and from 4 matched controls for each patient from the Longitudinal Health Insurance Database (LHID 2000), Taiwan. Controls were matched for age, sex, comorbid disorders, and enrollment date. All subjects were followed up from the date of enrollment until AMI, death, or the end of data collection (2009). Cox's regression model adjusted for age, sex, comorbid disorders, and medication was used to assess independent factors determining the risk of development of AMI. As expected, despite the matching, the hip fracture patients had more risk factors for AMI at baseline. A total of 8758 subjects with hip fractures and 35,032 controls were identified. Among these patients, 1183 (257 hip fracture patients and 926 controls) developed AMI during the median 3.2-year (interquartile range 1.4 to 5.8 years) follow-up period. Patients with hip fractures had a higher incidence of AMI occurrence when compared with controls (8.7/1000 person-years versus 6.82/1000 person-years). Multivariate analysis adjusted for baseline covariates indicated that hip fracture was associated with a greater risk for AMI development (hazard ratio [HR] ¼ 1.29; 95% confidence interval [CI] 1.12-1.48; p < 0.001). We conclude that hip fracture is independently associated with a higher risk of subsequent AMI. ß

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Section: Discussionmentioning

confidence: 99%

Hip fracture and risk of acute myocardial infarction: A nationwide study

Chiang

Liu

Chen

et al. 2012

Journal of Bone and Mineral Research

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show abstract

“…[1][2][3] Biomarkers of oxidative stress, such as serum malondialdehyde level measured as thiobarbituric acid-reactive substances, oxidized low-density lipoprotein, oxidation injury of DNA, 8-hydroxydeoxyguanosine and urinary excretion of 8-iso-prostaglandin-F2a, are generally measured in laboratories. [4][5][6][7] On the other hand, as indices of antioxidant potential, intracellular levels of superoxide dismutase and glutathione peroxidase have mainly been measured. [8][9] However, these assay methods are complex and are not suitable for analysis of a large number of subjects.…”

Section: Introductionmentioning

confidence: 99%

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

et al. 2011

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In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo. INTRODUCTIONOxidative stress may be involved in various disorders and pathogeneses, especially in lifestyle-related diseases, and it causes the progression and acceleration of atherosclerosis. 1-3 Biomarkers of oxidative stress, such as serum malondialdehyde level measured as thiobarbituric acid-reactive substances, oxidized low-density lipoprotein, oxidation injury of DNA, 8-hydroxydeoxyguanosine and urinary excretion of 8-iso-prostaglandin-F2a, are generally measured in laboratories. [4][5][6][7] On the other hand, as indices of antioxidant potential, intracellular levels of superoxide dismutase and glutathione peroxidase have mainly been measured. [8][9] However, these assay methods are complex and are not suitable for analysis of a large number of subjects. Recently, simpler methods for detecting reactive oxygen species (ROS) using derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were developed, and reports on studies using these methods have been increasing. [10][11][12][13][14][15][16][17][18][19][20] Thus, in the present study, we measured d-ROMS and BAP as indices for the production of ROS and antioxidant potential, respectively.

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“…Furthermore, earlier studies have also revealed an increase in lipid peroxidation, a type of free radical process, in patients with type II hypercholesterolemia [3]. Marinez-Sanches et al [18] note increased concentrations of MDA (malondialdehyde), the main end-product of lipid peroxidation, in patients with hypercholesterolemia, while Walter et al [19] demonstrate a correlation between the concentration of TBARS and the incidence of cardiovascular events. Uydu et al [20] report similar results following the use of atorvastatin in patients with hypercholesterolemia or hyperlipidemia: a decrease in the concentration of TBARS was seen after 12-week therapy at a dose of 10 mg/day.…”

Section: Discussionmentioning

confidence: 97%

The Effect of Combined Ezetimibe/Atorvastatin Therapy vs. Atorvastatin Monotherapy on the Erythrocyte Membrane Structure in Patients with Coronary Artery Disease: A Pilot Study

Jackowska¹,

Pytel²,

Koter−Michalak³

et al. 2016

Adv Clin Exp Med

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Serum levels of thiobarbituric acid reactive substances predict cardiovascular events in patients with stable coronary artery disease

Abstract: Serum levels of TBARS were strongly predictive of cardiovascular events in patients with stable CAD, independently of traditional risk factors and inflammatory markers.

Cited by 182 publications

References 43 publications

Hip fracture and risk of acute myocardial infarction: A nationwide study

Hip fracture and risk of acute myocardial infarction: A nationwide study

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects

The Effect of Combined Ezetimibe/Atorvastatin Therapy vs. Atorvastatin Monotherapy on the Erythrocyte Membrane Structure in Patients with Coronary Artery Disease: A Pilot Study

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