Serum Levels of Soluble Interleukin-2 Receptor in Renal Cell Carcinoma

Matsumoto, Takashi; Furukawa, Atsuko; Sumiyoshi, Yoshiteru; Akiyama, Kinya; Kanayama, Hiro‐omi; Kagawa, Shunsuke

doi:10.1016/s0090-4295(97)00476-7

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…Previous studies have shown that elevation of serum sIL-2R has a negative prognostic effect in patients with various malignant tumors, such as malignant melanoma [19, 20], head and neck cancer [21], nasopharyngeal carcinoma [22], non-Hodgkin's lymphoma [23, 24], and non-small cell lung cancer [25]. Matsumoto et al investigated the serum level of sIL-2R in 52 patients with RCC and 10 control subjects [26]. They also reported that measurement of sIL-2R in RCC patients provides useful information about the extent of disease and the survival time.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Masuda

Arai

Nishihara

et al. 2014

BioMed Research International

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To clarify the role of serum soluble T cell regulatory molecules in clear cell renal cell carcinoma (CCRCC), we measured the serum levels of soluble interleukin-2 receptor (sIL-2R), soluble B7-H3 (sB7-H3), and soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) in 70 CCRCC patients and 35 healthy controls. We investigated correlations between the serum levels of these soluble T cell regulatory molecules and the pathological grade, clinical stage, and prognosis of CCRCC. We also assessed the relations among each of these soluble molecules. As a result, the serum level of sIL-2R was significantly higher in CCRCC patients than in healthy controls (P < 0.05). In addition, elevation of serum sIL-2R was significantly correlated with the clinical stage (P < 0.001), and the survival of patients with high sIL-2R levels was shorter than that of patients with low sIL-2R levels (P < 0.05). Furthermore, the serum level of sB7-H3 was also significantly correlated with the clinical stage (P < 0.05), while the sIL-2R and sB7-H3 levels showed a positive correlation with each other (R = 0.550, P < 0.0001). These results indicate that the serum level of sIL-2R reflects tumor progression in CCRCC patients. In addition, the possibility was suggested that the IL-2/IL-2R and B7-H3 pathways may be involved in the progression of CCRCC.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Masuda

Arai

Nishihara

et al. 2014

BioMed Research International

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“…Multivariate analyses showed statistical independence for CRP, erythrocyte sediment rate (ESR), and serum soluble intercellular adhesion molecule‐1 (sICAM‐1) as predictors of overall patient survival 6. In recent studies, the levels of serum soluble CD95,7 soluble interleukin (IL)‐6,8 and IL‐2R9 also were reported to be prognostic parameters for RCC.…”

Section: Discussionmentioning

confidence: 99%

Significance of serum amyloid a on the prognosis in patients with renal cell carcinoma

Kimura

Tomita

Imai

et al. 2001

Cancer

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BACKGROUND Evidence of systemic inflammation, i.e., elevation of serum C–reactive protein, interleukin‐6, and/or the erythrocyte sedimentation rate, is correlated to poorer prognosis of patients with renal cell carcinoma (RCC). Serum amyloid A (SAA) has been recognized mainly as acute‐phase reactant. METHODS Serum SAA from 72 patients with RCC were examined. Thirty‐eight of 72 patients with RCC had elevated SAA compared with 17 healthy donors. RESULTS The disease specific survival rate was significantly lower in the elevated SAA group, and SAA level was shown to be an independent prognostic factor by univariate and multivariate analysis. CONCLUSIONS Evaluation of serum SM level in RCC patients may be a useful prognostic indicator. Cancer 2001;92:2072–5. © 2001 American Cancer Society.

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“…Serum levels of this peptide have been estimated in many disease entities including malignancies, diseases of autoaggression and inflammation/infectious-based processes, where sIL-2R serum concentration frequently correlated with disease severity (De Rie et al 1996, Itoh et al 1998, Kami et al 2000, Kapp et al 1988, Matsumoto et al 1998, Nakata et al 1998, Niitsu et al 2001, Spadaro et al 2001, Suenaga et al 1998, Tartour et al 2001, Vonderheid et al 1998). Monitoring of sIL-2R serum levels is a useful method for the assessment of disease intensity, efficacy of provided treatment, and for prediction of further illness course.…”

Section: Introductionmentioning

confidence: 99%

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

2009

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Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. The major challenge is the choice of optimal treatment. Assessment of treatment effectiveness is currently associated with clinical observations of disease activity based on Hurley's or Sartorius' grading system. Detailed examination of patients with HS and evaluation of disease severity is frequently time-consuming and undoubtedly subjective. With regard to these factors, there is a need for laboratory findings that will help resolve the problem. The aim of this study was to determine the usefulness of soluble interleukin-2 receptor (sIL-2R) serum concentration as a marker of HS clinical staging and comparative analysis with the commonly conducted laboratory measurements, including white blood cell count, C-reactive protein and erythrocyte sedimentation rate. The statistical analysis of all these laboratory parameters conducted within a group of 54 individuals with HS revealed that sIL-2R serum level seems to be the most sensitive measurement for evaluation of disease stage. Moreover, the existence of strong dependences between sIL-2R serum concentration and Hurley's HS grading system were demonstrated. In conclusion, we believe that sIL-2R serum level could be used as a valuable marker for disease staging in patients with HS.

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Serum Levels of Soluble Interleukin-2 Receptor in Renal Cell Carcinoma

Cited by 14 publications

References 16 publications

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

Significance of serum amyloid a on the prognosis in patients with renal cell carcinoma

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

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