Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

Abstract

Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. The major challenge is the choice of optimal treatment. Assessment of treatment effectiveness is currently associated with clinical observations of disease activity based on Hurley's or Sartorius' grading system. Detailed examination of patients with HS and evaluation of disease severity is frequently time-consuming and undoubtedly subjective. With regard to these factors, there is a need for laboratory findings that will help resolve the problem. The aim of this study was to determine the usefulness of soluble interleukin-2 receptor (sIL-2R) serum concentration as a marker of HS clinical staging and comparative analysis with the commonly conducted laboratory measurements, including white blood cell count, C-reactive protein and erythrocyte sedimentation rate. The statistical analysis of all these laboratory parameters conducted within a group of 54 individuals with HS revealed that sIL-2R serum level seems to be the most sensitive measurement for evaluation of disease stage. Moreover, the existence of strong dependences between sIL-2R serum concentration and Hurley's HS grading system were demonstrated. In conclusion, we believe that sIL-2R serum level could be used as a valuable marker for disease staging in patients with HS.

Decreased Number of Circulating Endothelial Progenitor Cells in Hidradenitis Suppurativa Patients

“…However, in the light of our study, it may be presumed that the increase in systemic inflammatory processes in HS sufferers, expressed as a significant increase in C-reactive protein and circulating proinflammatory cytokines (e.g. TNF-α), may possibly lead to impairment of endothelial repairing processes, resulting in poorer endothelial integrity and defective endothelial function [25,26]. Such dependences were already observed in other studies.…”

Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS)

“…Matusiak et al 8,10 reported in 2 studies There was a significant correlation between CRP level and neutrophil count with disease severity according to mHSS. Patients with HS and increased disease severity exhibited elevated CRP levels and neutrophil counts.…”

The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa

“…Matusiak et al [31] studied the serum TNF- α levels of 54 patients with HS and observed significantly higher levels in the HS patients compared with the healthy controls. In another study, they also identified the soluble IL-2 receptor as a potential marker of value for determining the severity of HS [32]. These articles initiated the study of serum inflammatory cytokines as biomarkers for HS.…”