Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy

Franca, Carlos; Nogueira, Carla; Ramalho, Andréa; Carvalho, Antônio Carlos Pires; Vieira, Sérgio Lannes; Penna, Antônio

doi:10.1093/annonc/mdq547

Cited by 30 publications

(25 citation statements)

References 20 publications

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“…Radiotherapy induces a much greater decrease of plasma Se level in patients with cancer. For example, It was noted in patients treated by radiotherapy for breast cancer that the mean serum Se level dropped from 86.4 μg/l before radiotherapy to 47.8 μg/l after it (15). In another study of 95 patients with brain metastases from non-small cell lung cancer, the mean plasma Se level decreased from 90.4 μg/l before radiotherapy to 56.3 μg/l after radiotherapy of the brain metastases (16) and this difference was statistically significant in a multivariate analysis independently of age, body mass index, smoking, alcoholism, prior chemotherapy and pathological types.…”

Section: Discussionmentioning

confidence: 99%

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

Collery¹,

Santoni

Mohsen

et al. 2016

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Abstract. It has been shown that a rhenium-(I)-It has been shown that a prolonged oral administration of amphiphilic rhenium-(I)-diselenoether complex allowed a dose-dependent uptake of the two major components of this drug, rhenium (Re) and selenium (Se) in healthy tissues, with highest uptake by the liver (1). Assays of these two elements have not yet been performed in tumorsThe combination of Se with a metal has already been described, with nickel as the metal (2). In that case, the presence of Se in the active site of hydrogenase enhanced its enzymatic property. Selective incorporation of Se into the active site of the molybdenum-iron (Mo-Fe) protein is essential for the catalytical effect of nitrogenase (3). Ironselenium ferredoxin with two clusters [4Fe-4Se] is present in the active site of a hydrogenase (4), with the same role as the iron-sulfur ferredoxin as a two-electron carrier.It is known that Re is able to bind DNA reversibly and that Re is found in the nucleus of malignant cells after the administration of Re-diselenoether (1, 5). It was also shown that the Re-diselenoether formed mono-adducts and bisadducts with a methyl-guanine, but also liberated the weakly chelating diselenoether ligand [supplementary material in (5)].Therefore we can hypothesize that while the Re core will have a role by interacting with DNA guanine bases, the diselenoether ligand will take Se to other targets.The anticancer activity of Re-diselenother has been demonstrated in experimental models of resistant triplenegative breast tumors (MDA-MB231), in malignant cells in culture, as well as after oral (5) or intraperitoneal administration (6) to tumor-bearing mice, at a daily dose of 10 mg/kg/day for 4 weeks, which was safe for the animals. The Re-diseleno ether compound we used, constituted an original chemical combination, and we aimed to complete the investigation of its biological role in an experimental model of cancer.The aim of this experiment was to test a lower dose of 5 mg/kg and to compare it with a 10-mg/kg dose. We evaluated the Re-complex as a single agent and in combination with paclitaxel, considered as a standard 5813

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Section: Discussionmentioning

confidence: 99%

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

Collery¹,

Santoni

Mohsen

et al. 2016

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“…Franca et al evaluated the effects of RT on plasma Se concentration in 209 breast cancer patients and reported a significant reduction in the plasma selenium concentration (p < 0.001) for the patients undergoing RT. 7 The role of SOD in breast cancer blood cells was also investigated by Pajovic et al 25 The authors stated that alterations in the SOD activity is directly related to the initiate status of this enzyme in the conditions of high baseline level of SOD activity, RT would decrease this activity, but in conditions in which the primary activity is medium or low, the activity would be approximately constant or might even increase after the RT. As another example, in the study carried out by Kasapovic et al on breast cancer patients, RT significantly increased the activities of SOD and CAT enzymes, but there were no steady changes in GPx activity in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…The study of Franca et al is consistent with our study as they showed a significant lowered selenium levels in breast cancer patients with advanced age (>60), compared before and after the RT. 7 As we know, Se plays very important roles in a number of biological processes. On the other hand, it is a component of Gpx enzyme and alteration in glutathione peroxidase activities depended on the serum Se concentration.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 Currently, surgery, radiotherapy (RT), chemotherapy and hormone therapy are effectively used for the treatment of cancer patients. 7,8 RT, as one of commonly used methods for the treatment of cancer, is able to destroy remaining cancer cells after surgery. 9 Patients with cancer need RT either for curative or palliative purposes, but unfortunately, this valuable method is associated with some major side effects.…”

Section: Introductionmentioning

confidence: 99%

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Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease

Arjmandi

Moslemi

Zarrini

et al. 2016

Reports of Practical Oncology & Radiotherapy

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“…In 2010, a Brazilian prospective study showed a significant reduction in plasma levels of selenium in breast cancer patients undergoing radiotherapy, suggesting attention to the nutritional status of this micronutrient and other antioxidant agents. 5 The thoughtful radiation oncologist is thus mainly concerned with the following clinical aspects: radioprotection of normal tissues, radio-sensitizing of malignant tumor cells, protection from edematous effects, and adjuvant measures for primary and secondary cancer prevention. 6 Clinical and experimental evidence indicates that Se could address most of these issues because it functions as a radio-and chemoprotector with the ability to alleviate the side effects of tumor-specific chemotherapy or radiotherapy treatments.…”

Section: Introductionmentioning

confidence: 99%

Multicenter, Phase III Trial Comparing Selenium Supplementation With Observation in Gynecologic Radiation Oncology

et al. 2014

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, on Behalf of the German Working Group Trace Elements and Electrolytes in Oncology-AKTE AbstractPurpose. In 2010, we reported that selenium (Se) supplementation during radiation therapy (RT) is effective for increasing blood Se levels in Se-deficient cervical and uterine cancer patients, and reduced the number of episodes and severity of RT-induced diarrhea. In the current study, we examine whether of Se supplementation during adjuvant RT affects longterm survival of these patients. Patients and Methods. Former patients were identified and questioned with respect to their health and well-being. Results. A total of 81 patients were randomized in the initial supplementation study, 39 of whom received Se (selenium group, SeG) and 42 of whom served as controls (control group, CG). When former patients were reidentified after a median follow-up of 70 months (range = 0-136), the actuarial 10-year disease-free survival rate in the SeG was 80.1% compared to 83.2% in the CG (P = .65), and the actuarial 10-year overall survival rate of patients in the SeG was 55.3% compared to 42.7% in the CG (P = .09). Conclusions. Our extended follow-up analysis demonstrates that Se supplementation had no influence on the effectiveness of the anticancer irradiation therapy and did not negatively affect patients' long-term survival. In view of its positive effects on RT-induced diarrhea, we consider Se supplementation to be a meaningful and beneficial adjuvant treatment in Se-deficient cervical and uterine cancer patients while undergoing pelvic radiation therapy.

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Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy

Abstract: Significant reduction in plasma levels of selenium is recorded in patients undergoing radiotherapy, suggesting attention to the nutritional status of this micronutrient and other antioxidant agents.

Cited by 30 publications

References 20 publications

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

Negative Impact of Total Body Irradiation on the Antitumor Activity of Rhenium-(I)-diselenoether

Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease

Multicenter, Phase III Trial Comparing Selenium Supplementation With Observation in Gynecologic Radiation Oncology

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