Serum levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in a population living in the Naples area, southern Italy

Esposito, Mauro; Serpe, Francesco Paolo; Diletti, Gianfranco; Messina, Antonietta; Scortichini, Giampiero; Rocca, Cinzia La; Baldi, Loredana; Amorena, Michele; Monda, Marcellino

doi:10.1016/j.chemosphere.2013.09.013

Cited by 46 publications

(33 citation statements)

References 29 publications

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“…[32][33][34] Although these experiments could be repeated with an antagonist of the orexin receptors and/or a blocker of the sympathetic activity, these findings well demonstrated the possibility that orexin A can induce hypophagia. [35,36] …”

Section: Second Experimentsmentioning

confidence: 99%

Orexin system increases energy expenditure by brown adipose tissue activity

Messina¹,

Monda²,

Villano³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Adipose tissue is a biological caloric reservoir that expands itself in response to overnutrition and releases lipids in response to energy deficit. It comprises white adipose tissue, the main energy storage, and brown adipose tissue (BAT), a key site of thermogenesis that dissipates chemical energy as heat. BAT is richly innervated by sympathetic nerve efferent fibers, and its development and activation are mediated by the sympathetic nervous system (SNS). Furthermore, substantial evidences show that BAT activation leads to increased thermogenesis. Thus, the regulation of the SNS tone provides a complex mechanism able to specifically coordinate the function of the organs involved in energy homeostasis. On the other hand, adipose tissue acts as an endocrine organ by producing various signaling cytokines and interacting with some neuropeptides as orexins. Orexins are produced by the lateral hypothalamus and evidences have suggested that orexins promote energy expenditure (EE) through modulation of locomotor activity and BAT thermogenesis. Recent data also suggest that orexins are required for BAT development, differentiation, and function. In the light of this, the orexin neuropeptides are part of a network able to increase EE through modulation of BAT thermogenesis which can be a target to new strategies to reduce the incidences of overweight and obesity. Aim of this review is to report our evidences showing that the autonomic nervous system influences food intake and energy consumption under various conditions, such as injection of orexins, which change the sympathetic and/or parasympathetic activities.

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Section: Second Experimentsmentioning

confidence: 99%

Orexin system increases energy expenditure by brown adipose tissue activity

Messina¹,

Monda²,

Villano³

et al. 2017

Natl J Physiol Pharm Pharmacol

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“…Numerous epidemiological and experimental studies have demonstrated that metabolic syndrome affects almost half of adults over 50-60 years [4,[6][7][8][9][10][11][12]. Probably, this incidence will grow in the future, considering spreading childhood obesity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Monacolin K of Red Rice and Glucomannan, Combined with a Low Calorie Diet, in Treatment of Dyslipidemia and Hypertension

Esposito¹,

Allocca²,

Adelfi³

2015

Biol Med (Aligarh)

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Alarming increase in incidence of cardiovascular disease is result of a nutrition pattern characterized by an increase in consumption of fats, cholesterol, sugar and other refined carbohydrates, concomitant with low consumption of polyunsaturated fatty acids and fibers. The purpose of this study was to evaluate the efficacy of the monacolin K of red rice and glucomannan, associated with low-calorie diet, on improvement of lipid profile and hypertension, symptoms of metabolic syndrome. In 180 Neapolitan patients with metabolic syndrome, we evaluated effects of monacolin K of red rice and glucomannan, associated with a low-calorie diet, on total cholesterol (CT), LDL cholesterol (LDL), HDL cholesterol (HDL), triglycerides (TG) and blood pressure (BP). The results showed a significant decrease in average value of CT (-20%), LDL (-25%), TG (-20%), with an increase in HDL (+15%) and a decrease in BP (-20%). These findings corroborate evidences showing a therapeutic effects of these nutraceuticals in the treatment of dyslipidemia and hypertension, when a low-calorie diet alone is ineffective. B io lo g y and M e d ic in e

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“…Obesity is a complex disorder characterized by an excess of body fat, usually caused by a lack of balance between energy intake and expenditure [1,2]. The World Health Organization has estimated that in 2014, more than 1.9 billion adults were overweight, 600 million of which were obese, and that in 2013, 42 million children under 5 years of age were overweight or obese [3].…”

Section: Introduction and Objectivesmentioning

confidence: 99%