2017
DOI: 10.5455/njppp.2017.7.0205422042017
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Abstract: Adipose tissue is a biological caloric reservoir that expands itself in response to overnutrition and releases lipids in response to energy deficit. It comprises white adipose tissue, the main energy storage, and brown adipose tissue (BAT), a key site of thermogenesis that dissipates chemical energy as heat. BAT is richly innervated by sympathetic nerve efferent fibers, and its development and activation are mediated by the sympathetic nervous system (SNS). Furthermore, substantial evidences show that BAT acti… Show more

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Cited by 2 publications
(2 citation statements)
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“…To support the role of orexins in obesity resistance, several animal studies have demonstrated that OrxA injections into several cerebral areas, such as the rostral LH, paraventricular nucleus, TMN, LC, DRN, nucleus accumbens, and substantia nigra, improve SPA and NEAT [ 132 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 ], while repeated injections of OrxA into LH are associated with reduced fat mass [ 153 ]. Orexins also exert a sympathoexcitatory effect, as demonstrated by increased blood pressure and heart rate, increased sympathetic outflow to brown adipose tissue (BAT), and increased plasma epinephrine and noradrenaline release [ 141 , 154 , 155 , 156 ]. The sympathetic outflow to BAT may be a cause of the increase in NEAT due to orexin [ 157 ].…”
Section: Feeding Behavior Energy Homeostasis and Obesitymentioning
confidence: 99%
“…To support the role of orexins in obesity resistance, several animal studies have demonstrated that OrxA injections into several cerebral areas, such as the rostral LH, paraventricular nucleus, TMN, LC, DRN, nucleus accumbens, and substantia nigra, improve SPA and NEAT [ 132 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 ], while repeated injections of OrxA into LH are associated with reduced fat mass [ 153 ]. Orexins also exert a sympathoexcitatory effect, as demonstrated by increased blood pressure and heart rate, increased sympathetic outflow to brown adipose tissue (BAT), and increased plasma epinephrine and noradrenaline release [ 141 , 154 , 155 , 156 ]. The sympathetic outflow to BAT may be a cause of the increase in NEAT due to orexin [ 157 ].…”
Section: Feeding Behavior Energy Homeostasis and Obesitymentioning
confidence: 99%
“…METs reflect the energy cost of PA as a multiple of the patient's resting metabolic rate. 20 EE ≥ 3.0 METs is considered to be at least moderate activity (Messina et al, 2017a;Zhu et al, 2018).…”
Section: Assessment Of Daily Life Physical Activitymentioning
confidence: 99%