Serum levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions

Bercovici, B; Wassermann, M.; Cucos, Simi; Ron, M.; D, Wassermann; Pines, Anatol

doi:10.1016/0013-9351(83)90176-7

Cited by 55 publications

(17 citation statements)

References 3 publications

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“…For PCB, some human studies have found statistically significant associations with spontaneous abortion (Bercovici et al, 1983; Leoni et al, 1989), while others have not (Dar et al, 1992; Axmon et al, 2004). There was a suggested, although not statistically significant, increase in stillbirth among women in the Yucheng cohort, who were exposed to high levels of PCB through contaminated cooking oil (Yu et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Maternal exposure to brominated flame retardants and infant Apgar scores

et al. 2015

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Brominated flame retardants (BFRs) and other persistent organic pollutants have been associated with adverse health outcomes in humans and may be particularly toxic to the developing fetus. We investigated the association between in utero polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB) exposures and infant Apgar scores in a cohort of Michigan residents exposed to PBB through contaminated food after an industrial accident. PBB and PCB concentrations were measured in serum at the time the women were enrolled in the cohort. PBB concentrations were also estimated at the time of conception for each pregnancy using a validated elimination model. Apgar scores, a universal measure of infant health at birth, measured at 1 and 5 minutes, were taken from birth certificates for 613 offspring born to 330 women. Maternal PCB concentrations at enrollment were not associated with below–median Apgar scores in this cohort. However, maternal PBB exposure was associated with a dose–related increase in the odds of a below–median Apgar score at 1 minute and 5 minutes. Among infants whose mothers had an estimated PBB at conception above the limit of detection of 1 part per billion, the odds ratio was 2.32 (95 % CI: 1.22– 4.40); for those with PBB ≥ 2.5 ppb the OR=2.62 (95% CI: 1.38-4.96; test for trend p< 0.01). Likewise, the odds of a below–median 5–minute Apgar increased with higher maternal PBB at conception. It remains critical that future studies examine possible relationships between in utero exposures to brominated compounds and adverse health outcomes.

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Section: Introductionmentioning

confidence: 99%

Maternal exposure to brominated flame retardants and infant Apgar scores

et al. 2015

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“…The average total urine porphyrin concentration for the workers was 94.5 pg/l versus 48.3 pg/l in the controls. In children transplacentally exposed to PCBs during Yu-Cheng, total urine porphyrin content was increased versus controls (95.2 pg/l vs 80.7 pg/l, respectively) (36) (38,39). Appreciable levels of total DDT in serum were also found in the affected women (119.6 vs 26.5 ng/ml).…”

Section: Biomarkers Ofeffectmentioning

confidence: 71%

Biomarkers for Great Lakes priority contaminants: halogenated aromatic hydrocarbons.

Feeley

1995

Environ Health Perspect

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“…Significant associations have been seen among malaria control, vineyard, and cotton field workers who have been exposed to a combination of organochlorine and other pesticides, the mean concentration of estimated DDE was 61 g/g fat in the malaria control program with the average exposure 15 years [44][45][46]. Other studies in India [47][48][49], the Ukraine [50], Israel [51,52], and China [53] have found elevated serum levels of DDT, or its metabolite DDE in women who have had a spontaneous or missed abortion. In a study of 1717 American women it was found that a median level of 25 g DDE/L serum was associated with a modest increased risk of SA, RR 1.1; however, the 95% CI (0.9-1.5) crossed 1.0 [54,55].…”

Section: Ddt/ddementioning

confidence: 97%

Reproductive Toxicology of Environmental Toxicants: Emerging Issues and Concerns

Younglai

Wu²,

Foster

2007

CPD

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Environmental toxicants comprise a number of man-made organic chemicals which may resist metabolism or their metabolites may persist in the environment and accumulate in the food chain. Some of these persistent chemicals are carried over long distances via the atmospheric transport and can have biological effects in fish, wildlife and humans. In this review the relationship between structure of these chemicals, their mode of action and their possible roles in adverse developmental and reproductive processes in humans will be discussed. The focus will be on model polychlorinated biphenyls and dioxins, organochlorines, phthalates, a constituent of cigarette smoke (benzo-a-pyrene), synthetic polymers (polybrominated diphenyl ethers and polyfluorinated compounds), and a fungicide (vinclozolin).

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Serum levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions

Cited by 55 publications

References 3 publications

Maternal exposure to brominated flame retardants and infant Apgar scores

Maternal exposure to brominated flame retardants and infant Apgar scores

Biomarkers for Great Lakes priority contaminants: halogenated aromatic hydrocarbons.

Reproductive Toxicology of Environmental Toxicants: Emerging Issues and Concerns

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