Serum levels of Organochlorine Pesticides and Breast Cancer Risk in Iranian Women

Paydar, Parisa; Asadikaram, Gholamreza; Fallah, Hossein; Nejad, Hamid Zeynali; Abolhassani, Moslem; Moazed, Vahid; Khazaeli, Payam; Heidari, Mahmood

doi:10.1007/s00244-019-00648-3

Cited by 24 publications

(12 citation statements)

References 33 publications

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“…It has been declared that organochlorine pesticides are known as endocrine-disrupting chemicals (Mnif et al, 2011), increase the risk of cancers including breast, prostate, stomach and lung cancer (Mouly & Toms, 2016;VoPham et al, 2017;Abolhassani et al, 2019;Paydar et al, 2019) and induce hepatic disorders. Dichlorodi-phenyltrichloroethane, (DDT), the most famous organochlorine pesticide and its metabolite p, p-dichlorodiphenyldichloroethylene (DDE) show endocrine-disrupting and carcinogenic effects (Matsushima, 2018).…”

Section: Pesticide Residue In Food Products and Their Toxicological Effectsmentioning

confidence: 99%

Probiotics as potential detoxification tools for mitigation of pesticides: a mini review

Mohammadi

Shadnoush

Sohrabvandi

et al. 2020

Int J of Food Sci Tech

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Pesticides play a key role in agriculture and food production by controlling the insects, weeds, plant pathogens and microbial contaminations. Although they are useful in some aspects, their inappropriate application can induce health problems including carcinogenicity, reproductive toxicity, neurodegenerative diseases and disruption of endocrine system. In this respect, efficient strategies should be applied to reduce pesticide residue in foodstuffs. Several methods have been proposed in food processing for reduction of pesticides residue. Recently, detoxification via microorganisms such as lactic acid bacteria and probiotics has been extensively studied and degradation of pesticides through hydrolytic enzymes has been introduced as the possible mechanism and it has been highlighted that some probiotics harbour pesticide-degrading genes. The aim of this review is to evaluate the efficacy of probiotics in detoxification of pesticides.

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Section: Pesticide Residue In Food Products and Their Toxicological Effectsmentioning

confidence: 99%

Probiotics as potential detoxification tools for mitigation of pesticides: a mini review

Mohammadi

Shadnoush

Sohrabvandi

et al. 2020

Int J of Food Sci Tech

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“…DDT and its derivatives, hexachlorocyclohexane (HCH) and chlorinated cyclodiene, are three members of the OCP family that have a long half-life and are hard to break down in the environment and foods (Paydar et al, 2019;Pirsaheb et al, 2015). Due to their high accumulation and persistence in the body, the use of OCP family pesticides has been banned since the 1980s (He et al, 2017;Paydar et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Although the primary etiology of lung cancer development has not been elucidated completely, it is widely accepted that multiple risk factors including genetic and environmental factors are linked to its development(Luo et al, 2011). Recently, pesticide exposure has been considered a new cancer risk factor(Abolhassani et al, 2019;Mortazavi et al, 2019b;Paydar et al, 2019). The present study was designed to compare the levels of OCPs, OPPs, and OS components between patients with lung cancer and healthy subjects.…”

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confidence: 99%

Oxidative Stress Induction By Pesticides May Cause Lung Cancer Incidence

Asadikaram

Pourghdamyari

Abolhassani

et al. 2022

Preprint

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Background and aims: Pesticides are nowadays known as one of the most important causes of human disorders worldwide. The aim of the present study was to investigate the role of organochlorine pesticides (OCPs) and organophosphorus pesticides (OPPs) in the development of lung cancer. Methods We determined the levels of seven derived OCP residues (α-HCH, β-HCH, γ-HCH, 2,4 DDT, 4,4 DDT, 2,4 DDE, and 4,4 DDE) and enzymatic antioxidant biomarkers including paraoxonase-1 (PON-1), erythrocyte's acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and non-enzymatic antioxidant biomarkers including total antioxidant capacity (TAC), protein carbonyl (PC), malondialdehyde (MDA), and nitric oxide (NO) in the blood samples of 51 lung cancer patients and 51 healthy subjects as controls. Furthermore, the effects of OPP exposure on the development of lung cancer and oxidative stress (OS) are indirectly assessed by measuring AChE and PON-1 enzyme activities. Results The average values of all the measured OCPs were significantly higher in lung cancer patients when compared with healthy control subjects. AChE, PON-1, GPx, and CAT activity levels as well as the amounts of PC, MDA, and NO were higher in patients with lung cancer than in the control subjects, while TAC values were lower in the patients. Moreover, our data showed a significant association between OCP concentrations and OS parameters. Conclusion The results suggest that OCPs and OPPs may have a role in lung cancer incidence in southeastern Iran, and at least one of the mechanisms by which OCPs and OPPs may contribute to increasing the development of lung cancer in the studied area is through OS generation.

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“…Moreover, given the bioaccumulation of OCPs in fatty tissues, these pesticides have been observed in various human tissues in enormous amounts (2). Previous studies have shown that long-term exposure to these pesticides increases the risk of developing multiple types of cancer (3)(4)(5). One of the critical mechanisms considered to be associated with the role of pesticides in the development of cancers is epigenetic modifications (6).…”

Section: Introductionmentioning

confidence: 99%

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

Yousefi

Asadikaram

Karamouzian

et al. 2021

Environ Health Eng Manag

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Background: Alterations in the methylation levels of tumor suppressor genes are considered as one of the essential aspects of malignancies. The present study explored the association of O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation, as a tumor suppressor, with some organochlorine pesticides (OCPs) in primary brain tumor (PBT) patients. Methods: The present study was conducted on a total of 73 PBT patients. The patients’ serum was analyzed using gas chromatography for seven OCP derivatives. The methylation-specific PCR (MSP) method was also used to determine the methylation status of the MGMT promoter. Results: The current findings demonstrated that the methylation of MGMT promoter occurred in 22 out of 34 glioma cases (64%), but in only one out of 35 meningioma cases. No MGMT promoter methylation was observed in other PBT, hemangioma, and anaplastic medulloblastoma stages. Besides, there were significant associations between MGMT methylation and γ-HCH (odds ratio [OR]: 1.50; 95% CI: 1.03- 2.40, P=0.04), 4,4DDE (OR: 1.44; 95% CI: 1.01- 2.05, P=0.02), 2,4 DDT (OR: 1.23; CI: 1.04- 1.45, P=0.03), and 4,4DDT (OR: 1.46; CI: 1.23- 2.15, P=0.02) in glioma patients. Conclusion: The results of the study suggested that the hypermethylation of the MGMT promoter in glioma patients is associated with increased OCPs in their serum, especially γ- HCH, 4,4DDE, 2,4DDT, and 4,4DDT. Moreover, it may lead to the hypermethylation of the MGMT promoter gene. Hence, it can be concluded that exposure to OCPs may potentially induce glioma.

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Serum levels of Organochlorine Pesticides and Breast Cancer Risk in Iranian Women

Cited by 24 publications

References 33 publications

Probiotics as potential detoxification tools for mitigation of pesticides: a mini review

Probiotics as potential detoxification tools for mitigation of pesticides: a mini review

Oxidative Stress Induction By Pesticides May Cause Lung Cancer Incidence

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

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