MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

Yousefi, Fatemeh; Asadikaram, Gholamreza; Karamouzian, Saeid; Abolhassani, Moslem; Moazed, Vahid; Nematollahi, Mohammad Hadi

doi:10.34172/ehem.2021.07

Cited by 5 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They can harm humans and animals via skin absorption, inhalation, and dietary intake, as well as contaminating the environment [2]. Improper use of pesticides in agriculture leads to changes in the level of antioxidant and oxidant enzymes in the human body, and thus results in the development of diseases caused by oxidative stress [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Abdollahdokht

Gao

Faramarz

et al. 2022

Chem. Biol. Technol. Agric.

Self Cite

View full text Add to dashboard Cite

Pesticides are classified into several groups based on their structure, including fungicides, insecticides, herbicides, bactericides, and rodenticides. Pesticides are toxic to both humans and pests. For pest control, a very small amount of pesticides reach their target pests. Therefore, nearly all pesticides move through the environment and exert adverse effects on beneficial biota and public health. These chemicals pollute the water, soil, and atmosphere of the ecosystem. Agricultural workers in greenhouses and open fields, exterminators of house pests, and workers in the pesticide industry are occupationally exposed to pesticides. Pesticide exposure in the general population primarily happens through the consumption of food and water contaminated with pesticide residues; however, substantial exposure can also occur outside or inside the house. Currently, intelligent, responsive, biodegradable, and biocompatible materials have attracted considerable interest for the formulation of green, safe, and efficient pesticides. It was indicated that utilizing nanotechnology to design and prepare targeted pesticides with an environmentally responsive controlled release via chemical modifications and compounds offers great potential for creating new formulations. Furthermore, biopesticides include microbial pesticides, which are naturally happening biochemical pesticides. In addition, pesticidal substances generated by plants with added genetic materials, i.e., plant-incorporated protectants (PIPs), have emerged. Based on the foregoing evidence, various types of pesticides are summarized in this review for the first time. Here, new pesticides including nano-pesticides and biopesticides are discussed while focusing on the most recent findings on targeted and safe nano-formulated biopesticides and nano-pesticides. Graphical Abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Abdollahdokht

Gao

Faramarz

et al. 2022

Chem. Biol. Technol. Agric.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The active compounds of pesticides are typically organophosphates (OPPs), chlorinated hydrocarbons (OCPs), carbamates, and carbamide derivatives (Tadeo et al, 2019). These compounds are widely applied on farms and residential areas for pest control; however, exposure to them can have detrimental effects on human health (Dumat et al, 2019; Yousefi et al, 2021; Abdollahdokht et al, 2021; Abbasi-Jorjandi et al, 2020). Pesticides can be absorbed by humans and animals through skin, inhalation, and ingestion (Rostamabadi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to pesticides in farmworkers and the oxidative markers

Samareh

Asadikaram

MojtabaAbbasi-Jorjandi

et al. 2022

Toxicol Ind Health

Self Cite

View full text Add to dashboard Cite

Organophosphate (OPPs) and organochlorine pesticides (OCPs) are the two predominant forms of pesticides extensively used all around the world and are being reconsidered as environmental pollutants. The current study sought to assess the role of socioeconomic factors on the level of pesticides residues and the oxidative effects of exposure to OPPs and OCPs among the farmworkers of southeast Iran. In this cross-sectional study, 192 farmworkers and 74 non-farmworkers (controls) were involved. Gas chromatography (GC) was performed to measure the serum levels of organochlorine chemicals (2,4-DDT, 4,4-DDT, 2,4-DDE, 4,4-DDE, α-HCH, β-HCH, and γ-HCH). Furthermore, acetylcholinesterase (AChE) activity, arylesterase activity of paraoxonase-1 (PON-1), and several oxidative stress (OS) markers were assessed. In addition, the impact of several parameters such as home to farm distance, education level, ventilation status, and personal protective equipment (PPE) on pesticide levels was analyzed. The levels of OCPs in the farmworkers were significantly higher than the control subjects. In addition, AChE activity, arylesterase activity of PON-1, and total antioxidant capacity in farmworkers were significantly less, and MDA levels were higher than the controls. Education level was associated with farmworkers’ protective behavior. The current findings suggested that some phased out OCPs can still be measured in human samples in the southeast of Iran. Furthermore, the current study demonstrated that exposure to OCPs and OPPs was accompanied by adverse consequences regarding OS parameters and subsequent health problems. In addition, the findings of the present study suggest that improving farmworkers’ education might be associated with reduced exposure to pesticides and less adverse health effects.

show abstract

An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides

Pratap Singh Raman,

Thakur,

Pandey

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Numerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and the environment. Accurately quantifying pesticide residues is essential for risk evaluation and regulatory purposes. Numerous analytical methods have been developed and utilized to achieve sensitive and specific detection of pesticides in intricate samples like water, soil, food, and air. Electrochemical sensors based on amperometry, potentiometry, or impedance spectroscopy offer portable, rapid, and sensitive detection suitable for on‐site analysis. This study examines the potential of electrochemical sensors for the accurate evaluation of various effects of pesticides. Emphasizing the use of Graphene (GR), Graphene Oxide (GO), Reduced Graphene Oxide (rGO), and Graphdiyne composites, the study highlights their enhanced performance in pesticide sensing by stating the account of many actual sensors that have been made for specific pesticides. Computational studies provide valuable insights into the adsorption kinetics, binding energies, and electronic properties of pesticide‐graphene complexes, guiding the design and optimization of graphene‐based sensors with improved performance. Furthermore, the discussion extends to the emerging field of biopesticides. While the GR/GO/rGO based sensors hold immense future prospects, their existing limitations have also been discussed, which need to be solved with future research.

show abstract

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

Cited by 5 publications

References 20 publications

Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Conventional agrochemicals towards nano-biopesticides: an overview on recent advances

Occupational exposure to pesticides in farmworkers and the oxidative markers

An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides

Contact Info

Product

Resources

About