Serum levels of nitric oxide and endothelin-1 in patients treated with continuous ambulatory peritoneal dialysis

Kovačević, Peđja; Dragic, Sasa; Rajkovača, Zvezdana; Veljković, Slavimir; Kovačević, Tijana

doi:10.3109/0886022x.2013.867812

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…Uzun et al, also found that patients in PD, without HD, have lower levels of NO compared with HC (22). However, Kovačević et al, found increased levels of NO in CAPD (55). The reason of these different outcomes may be explained by the effect of PM solute transport rate among the patient in PD.…”

Section: Discussionmentioning

confidence: 98%

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

et al. 2019

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Peritoneal dialysis (PD) is an alternative for managing the end-stage renal disease (ESRD). The peritoneal membrane (PM) is not just a membrane that passively responds to diffusion and convection. The characteristics of PM result in the peritoneal equilibrium test (PET) and with this test is possible to obtain the type of peritoneal transport (PT). The patient on PD can be classified in different types of PT as; Low, Low Average, High Average, and High. The aim of the study was to compare the inflammatory cytokines, oxidants, antioxidants, and oxidative DNA damage markers in the different types of PT. A cross-sectional analytical study of 77 adult PD patients was performed. Levels of lipoperoxides (LPO) were higher in all types of PT vs. healthy volunteer controls (HC) (p < 0.0001). Nitric oxide (NO) levels were found significantly down-regulated in all types of PT (p < 0.0001). The activity of the superoxide dismutase enzyme (SOD) was found to be significantly increased in all types of PT vs. the HC (p < 0.0001). The levels of the DNA repair enzyme were found to be decreased in all types of PT. The levels of the pro-inflammatory cytokines TNF-α, IL-6, the marker of oxidative DNA damage, 8-IP and the total antioxidant capacity (TAC) were all significantly decreased, contrary to the levels in HC, possibly by the clearance in the dialysis fluid in all types of PT or due to down-regulation of their expression. In conclusion, we found significant changes in markers of inflammation, oxidative stress, and oxidative damage to DNA in all types of PT; Low, low average, high average, and high PT in the values of D/P creatinine at 4 h compared to HC.

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Section: Discussionmentioning

confidence: 98%

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

et al. 2019

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“…In the literature, the results of the studies that investigated the plasma levels and effects of NOx in patients with CKD were controversial. Some studies have supported that plasma NOx levels were lower in CKD patients (23,(26)(27). Total NO production was in a small number of patients with chronic renal failure, but the patient group was reported to be hypertensive during the investigation (28).…”

Section: Discussionmentioning

confidence: 98%

“…Physiological and pathophysiological mechanisms of CKD can cause damage of endothelium or blood vessels. It was shown that the disturbances of vasoactive substances like NOx production can result in significant hemodynamic problems and atherosclerosis in patients with CKD (23). The plasma concentration and urinary excretion of NO 2 and NO 3 (NOx; the stable oxidation products of NO) are now being widely used to give a measure of total NO production in vivo (24,25).…”

Section: Discussionmentioning

confidence: 99%

“…Total NO production was in a small number of patients with chronic renal failure, but the patient group was reported to be hypertensive during the investigation (28). On the other hand, the results of some studies on the plasma NOx levels of dialysis patients supported the high plasma NOx values resulting from a complete loss of renal clearance and the removal of NO inhibitors such as asymmetric dimethylarginine (ADMA) by dialysis (15,23,(28)(29)(30). Recent data also supported our finding that higher degree of inflammation and stimulation of the inducible form of nitric oxide synthase results in higher values of NOx in CKD patients (31,32).…”

Section: Discussionmentioning

confidence: 99%

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Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease

Buyan¹,

Akçaboy²,

Goktas³

et al. 2017

Turk J Med Sci

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IntroductionWhole blood viscosity (WBV) is increasingly recognized as a factor implicated in the genesis of atherosclerosis and the progression of vascular disease, such as chronic kidney disease (CKD), in high-risk patients. The principal determinants of WBV are hematocrit, red blood cell deformability, and the viscosity of plasma. Changes in whole blood viscoelasticity are associated with cardiovascular and cerebrovascular complications among patients with CKD, especially in the fifth stage (1-3). Mechanical interaction between blood and vessels mediated by WBV has a crucial role in the release of endothelium-derived mediators such as NOx and endothelin, and subsequent vascular remodeling (1,4).The aim of the study was to investigate the effects of WBV and plasma NOx values on cerebral and cardiovascular risks associated with CKD and to compare the impact of hemodialysis (HD) and peritoneal dialysis (PD) treatments on WBV and plasma NOx levels in patients with CKD. Materials and methodsA cross-sectional study was performed in patients who were admitted to our pediatric nephrology department. The study fulfilled the requirements of good clinical practice according to the Declaration of Helsinki, and was approved by our local ethics committee (Date: 13.04.2011, Number: 66). Patients and their families were informed, and all subjects gave written informed consent prior to enrollment.Background/aim: The aim of the study was to investigate the effects of whole blood viscosity and plasma nitric oxide on cerebral and cardiovascular risks associated with chronic kidney disease. Materials and methods:The study group consisted of 40 pediatric patients and 21 healthy control subjects. Hematologic and biochemical variables, viscosity and plasma nitric oxide levels, echocardiographic findings, and middle cerebral artery blood flow velocity were examined.Results: Viscosity values of patients were significantly lower than those of the control group. Lower values of hematocrit, total protein, and albumin and higher values of ferritin in all patient groups resulted in significantly low viscosity levels. Plasma nitric oxide levels were higher in all patient groups than those in the controls. No statistically significant difference was present in middle cerebral artery blood flow velocity between the patient and control groups. Even when systolic functions were normal, the patient group had significant deterioration in diastolic functions, suggesting morbidity and mortality risks. Conclusions:Cerebral blood flow velocities were not affected by viscosity and nitric oxide levels, suggesting that cerebral circulation has the ability to make adaptive modulation. The metabolism of nitric oxide levels needs further investigation and studies in patients with chronic renal disease.

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“…In addition, it is unclear whether different type of dialysis (HD or CAPD) reduces or increases plasma concentrations of ET-1 and big ET-1, because previous studies, which only studied HD-induced changes in ET-1, have demonstrated conflicting results. 24,25 On the other hand, the role of ET-1 in lung diseases is significant and the number of respiratory tract disorders in which pathophysiology of this molecule holds a crucial role is rising. 19 Apart from pulmonary hypertension where ET-1 has a considerable effect, obstructive pulmonary diseases as well as pulmonary fibrosis should be also considered.…”

Section: Discussionmentioning

confidence: 99%

Impact of prolonged duration of different types of renal replacement therapies on serum levels of endothelin-1 and pulmonary function tests

Kovačević¹,

Dragic²,

Zlojutro³

et al. 2021

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Introduction: This study was carried out to investigate the impact of duration of different renal replacement therapies such as hemodialysis and continuous ambulatory peritoneal dialysis on potential overproduction of endothelin-1 (ET-1) and pulmonary function tests in these patients. Materials and methods: The study included 26 patients (14 males, mean age 54.9±16.2 years) with end stage renal diseases (ESRD) receiving regular hemodialysis (HD) and 23 patients (10 males, mean age 55.8±15.8 years) with ESRD treated with continuous ambulatory peritoneal dialysis (CAPD). The spirometry values were recorded before the onset of HD and prior to emptying the peritoneal cavity in CAPD patients and ET-1 was measured using the enzyme immunoassay (EIA) methodology. Two groups of patients (groups 1 and 2) were further divided into subgroups (group A and group B). Groups A (1-A and 2-A) included patients treated with any type of renal replacement therapy (RRT) (HD or CAPD) less than 5 years, and groups B (1-B and 2-B) included patients treated with any type of RRT (HD or CAPD) longer than 5 years. Results: Patients treated with HD or CAPD for more than five years were found to have significantly higher serum levels of ET-1 (HD = 41.49±21.28 vs. 185.13±73.67, p<0.01; PD = 51.24±32.11 vs. 139.53±42.42, p<0.01, respectively). Values of most pulmonary function parameters differed significantly between groups treated longer or shorter than 5 years: FVC (HD = 108.4±13.34 vs. 80.82±11.26, p<0.01; CAPD = 97.20±18.99 vs. 73.25±10.73, p<0.01, respectively), FEV1 (HD = 108.33±15.8 vs. 76.73±4.9, p<0.01; CAPD = 100.67±18.31 vs. 66.75±6.25, p<0.01, respectively). Conclusions: Prolonged duration of any type of renal replacement therapy is associated with higher serum levels of ET-1 and with lower pulmonary function tests in ESRD patients.

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Serum levels of nitric oxide and endothelin-1 in patients treated with continuous ambulatory peritoneal dialysis

Cited by 7 publications

References 31 publications

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

The Behavior of the Type of Peritoneal Transport in the Inflammatory and Oxidative Status in Adults Under Peritoneal Dialysis

Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease

Impact of prolonged duration of different types of renal replacement therapies on serum levels of endothelin-1 and pulmonary function tests

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