Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease

Impact of periodontitis on chemokines in smokers

“…The data in literature on the impact of smoking in patients with CP on CC chemokines is limited [44,51]. Significantly higher serum levels of MCP-1 have been reported in patients with CP compared to healthy controls [52]. The biological impact of the elevated MCP-1 levels on the disease processes in periodontitis is not fully clear and will require further studies to elucidate its function.…”

Toll like receptor 5 ligand induces monocyte chemoattractant protein-1 in mouse osteoblastic cells

“…The results of this study show that in MC3T3-E1 cells, flagellin significantly induced MCP-1 mRNA and protein production, and that the JNK and MEK-ERK1/2 signaling pathways are involved in MCP-1 induction. As MCP-1 is related to the severity of periodontal diseases (3,24), our results indicate that flagellin may play an important role in the progression of periodontal disease. Results of further studies will provide more insight regarding the role of chemokines and their inhibition in the prevention of periodontal disease.…”

“…Very high levels of MCP-1 have been reported in the gingival crevicular fluid of aggressive periodontitis subjects (3). In addition, Pradeep et al (24) showed that serum MCP-1 levels increased proportionally with the severity of periodontal disease.…”

Ligature-Induced Periodontitis Increased Insulin Resistance and Triglyceride Levels in Wistar Rats

“…Endo et al 15) had measured the level of TNF-α 4 weeks after ligature; thus, the diff erences in the strain of rat and the duration of periodontitis might explain the diff erent eff ects of experimental periodontitis on the level of TNF-α in the two studies. Enhanced MCP-1 expression in the sera of patients with periodontal diseases has been demonstrated in previous studies 24) . Endothelial cells, along with mononuclear phagocytes, have been reported to be the main sources of MCP-1 expression in chronic periodontitis 25,26) .…”