Serum Levels of miR-143 Predict Survival in Critically Ill Patients

Abstract

Background and Aims Recent data suggested a potential role of miR-143 as a biomarker for systemic inflammation and infection. However, its role in critical illness and sepsis is only poorly understood. Methods We determined circulating levels of miR-143 in 218 critically ill patients, of which 135 fulfilled sepsis criteria, and compared them to 76 healthy controls. Results were correlated with clinical records. Results In the total cohort of critically ill patients from a medical intensive care unit (ICU), miR-143 serum levels tended to be lower compared to healthy control samples, but this difference did not reach statistical significance. In ICU patients, serum levels of miR-143 were independent of disease etiology, including the presence of sepsis, or severity of disease. Importantly, low miR-143 serum levels were associated with an unfavorable short- and long-term prognosis in ICU patients. Our study identified different optimal cut-off values at which low miR-143 serum levels predicted mortality with a high diagnostic accuracy. In line with this, concentrations of circulating miR-143 correlated with markers of organ failure such as creatinine, bilirubin, or lactate in our cohort of critically ill patients. Conclusion Low miR-143 serum levels are indicative for an unfavorable short- and long-term prognosis in critically ill patients admitted to a medical ICU. Our data suggest a previously unrecognized role for miR-143 measurements as a novel prognostic marker in critically ill patients.

Diagnostic Value of miR-103 in Patients with Sepsis and Noninfectious SIRS and Its Regulatory Role in LPS-Induced Inflammatory Response by Targeting TLR4

“…The decreased expression of miR-21 was reported in patients with sepsis and exhibited a good value to predict sepsis risk and thus was determined as a candidate biomarker for the development and progression of sepsis [25]. In patients collected from ICU, a low-level serum of miR-143 was indicated to be an indicator to predict the onset of sepsis and disease severity [26]. These previous results indicate the critical roles of deregulated miRNAs in the pathogenesis of sepsis.…”

Hsa-miRNA-143-3p Regulates Differentiation of Human Stem Cells From The Apical Papilla Through Targeting Nuclear Factor I-C

“…miR-143-3p has been found to act as a key regulator in various biological processes and diseases, and become one of the best known of the tumor suppressor miRNA [21] by targeting several oncogenes in various human cancers, such as breast cancer [22] , gastric cancer [23] , renal cell cancer [24] . miR-143 serum levels were recently suggested as a biomarker for critical illness and sepsis [25] . However, we have not found definite reports on cellular behavior of hSCAPs influenced by miR-143-3p.…”

Expression, Regulation and Functions of MicroRNAs in Autoimmune Hepatitis

“…miR-143 has been found to play an important role in angiogenesis, cardiac morphogenesis and tumorigenesis [90][91][92]. miR-143 is also involved in inflammation and infection [92].…”

“…miR-143 has been found to play an important role in angiogenesis, cardiac morphogenesis and tumorigenesis [90][91][92]. miR-143 is also involved in inflammation and infection [92]. For instance, miR-143 targeted glucose transporter 1 (Glut-1) and overexpression of miR-143 could significantly promote central memory T CD8+ cell differentiation, suppress cell apoptosis, and increase pro-inflammatory cytokine production [93].…”