Serum Levels of Metal Ions in Female Patients with Breast Cancer

Abstract

The present study highlights the role of calcium, copper, iron, phosphorus, magnesium and zinc in the pathogenesis of breast cancer. The estimation of serum levels of these metal ions has a potential role in early detection and monitoring of breast cancer.

Serum Levels of Selenium and Zinc in Patients with Breast Cancer: A Case-Control Study

“…Also, Wu et al (28) reported that there was a significant difference in concentrations of 13 elements in serum between patients with BC and controls, the most important of which were Cadmium, Manganese, Iron, Chromium, and Zn. In this study, the serum levels of Zn and Se was significantly lower in patients with BC compared with the control group; regarding Zn, the results of this study were in line with the results of studies conducted by Pavithra et al (29) in India and Yucel et al (30) in Ankara, Turkey; also, regarding Se, result of this study were in line with the results of the studies in Iran (31), Spain (32), India (33), Greece (34), and Nigeria (35).…”

Biochemical Study of Serum Zinc in Patients of Breast Carcinoma in Bikaner District

“…12,13 The result of present study of serum Zn level was similar to results obtained by previous studies which suggested that serum Zn level in breast carcinoma patients decreases significantly as reported by Davies et al(1968), 14 Tinoco-Veras et al (2011) 15 , Alam et al (2012) , 16 Pavithra et al (2015). 17 Although, the mechanism underlying the deviation of serum zinc in malignancy is not clear but however the decrease in serum zinc level might be due to stress induced by the malignancy. Davies et al (1968) 14 reported that many factors including various diseases and stress induce the lowering of serum zinc concentration.…”

The Quantitative Serum Brca1and Serum Zinc as a Novel Biomarkers With the Correlations Between Them in the Familial Breast Cancer Patients in Iraq.

“…[1] In this study, there was a significant decrease of mean serum zinc in BC patients 87(ug/dl) compared with HCs 103(ug/dl) (p<0.001) according to the OCV of the current study (95.5ug/ml). This result is similar to the results obtained by previous studies which suggested that serum Zn level in BC patients decreases significantly as reported by (Alam et al in 2012) 9 and (Pavithra et al in 2015) [14] , and with a meta-analysis containing random effects model with 12 studies which recorded a decreased in mean serum zinc level in BC group, in contrast to six studies which recorded no significant differences and with one study which recorded a significant increase in mean serum zinc in BC patients compared with HCs (Gumulec J.…”