Serum levels of interleukin-1, interleukin-6 and tumour necrosis factor-alpha in patients with gastric carcinoma

Kabir, Shahjahan; Grant, Christopher S.; Daar, Abdallah S.

doi:10.1016/0304-3835(95)03895-4

Cited by 66 publications

(52 citation statements)

References 18 publications

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“…In our study, the mean level of platelet counts was 253.23±88.47×1000/μL, and 7.5% of gastric cancer patients had thrombocytosis, which was coincident with previous literatures (Aliustaoglu et al, 2010;Heras et al, 2010). Although the mechanism responsible for the elevated levels of serum IL-6 and TPO in cancer patients remains vague, it had been confirmed that the significantly higher frequency of elevated IL-6 levels (Kabir and Daar, 1995) and up-regulation of TPO (McConnell et al, 2007) were observed in patients with malignancies in many reports. Meanwhile, cancer cells can release vascular endothelial growth factor (VEGF), which activates the coagulation cascade, resulting in platelets to be activated (Kuenen et al, 2002;Roselli et al, 2003).…”

Section: Discussionsupporting

confidence: 91%

Significance of Thrombocytosis in Clinicopathologic Characteristics and Prognosis of Gastric Cancer

Wei

Zhang

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: We aimed to study the relationship between thrombocytosis and clinical features of gastric cancerfocussing on platelet counts and gastric cancer progression through different TNM stages. Methods: According to the normal range of platelet count in our institution, 1,596 patients were divided to two groups: a thrombocytosis group (120 patients, >400×1000/μL) and a control group (1,476 patients, ≤400×1000/μL). Results: The incidence of thrombocytosis was 7.5%. Higher platelet counts were observed in patients with older age, larger tumor size, deeper invasion, lymph node metastasis, distant metastasis and advanced TNM stage. In multivariate logistic regression, tumor size, depth of tumor invasion, lymph node metastasis and TNM stage were independent risk factors for thrombocytosis of gastric cancer patients. On prognostic analysis, age, tumor size, tumor location, histologic type, depth of tumor invasion, lymph node metastasis, distant metastasis and TNM stage and platelet count were important factors. Tumor size, invasion depth, lymph node metastasis, TNM stage and the platelet count were independent prognostic factors. Conclusion: Thrombocytosis is associated with clinical features of gastric cancer patients and correlates with a poor prognosis.

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Section: Discussionsupporting

confidence: 91%

Significance of Thrombocytosis in Clinicopathologic Characteristics and Prognosis of Gastric Cancer

Wei

Zhang

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The correlation of soluble ICAM-1 and VCAMeatment 1 with total white cell count suggests a role for inflammatory reactions. The expression of both ICAM-1 and VCAM-1 on y stage of disease endothelial cells is known to be rapidly up-regulated by inflammatory cytokines and there are reports of increased serum levels of interleukin 1 and interleukin 6 in patients with gastric cancer (Kabir et al, 1995;Wu et al, 1996). It has been shown that stimulation of cultured normal human hepatocytes with proinflammatory r investigation into the cytokines induces cell-surface expression of ICAM-1 and secres prognostic markers.…”

Section: Resultsmentioning

confidence: 99%

Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer

Velikova

Banks²,

Gearing³

et al. 1997

Br J Cancer

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Summary The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology, survival and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with gastric cancer in comparison with the group of healthy subjects (P < 0.00001 and P < 0.0001 respectively). Increased serum concentrations of VCAM-1 were associated with locally advanced and metastatic disease whereas ICAM-1 was significantly elevated both in local and in advanced/metastatic disease. Soluble E-cadherin and E-selectin concentrations did not show any significant elevation in gastric cancer patients. Concentrations of soluble adhesion molecules showed significant correlation with each other (except E-selectin and VCAM-1) and with alkaline phosphatase. Soluble ICAM-1 and VCAM-1 were significantly associated with an elevated total white cell count. Patients with elevated VCAM-1 had significantly poorer survival in comparison with patients with normal serum levels (P= 0.0361).

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“…Detection of the increased expression of IL-6 could be therefore anticipated in many cancer patients as their conditions deteriorated. There is a good reason then to believe that IL-6-IL-6R loop may play an important role in autocrine growth of tumour cells (Kawano et al, 1988;Miki et al, 1989;Blay et al, 1992;Ni and O'Neill, 1992;Kabir and Daar, 1995;Oka et al, 1996;Wojciechowska-Lacka et al, 1996;Seymour et al, 1997). Nonetheless, these have not been consistently found for all the cancer cells in a given tumour type (Baba et al, 1995;Yanagawa et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, serum levels of IL-6 were also demonstrated to correlate with adverse prognosis in patients with metastatic renal cell carcinoma (Blay et al, 1992), ovarian cancer (Scambia et al, 1995), gastric cancer (Kabir and Daar, 1995;Wu et al, 1996), lung cancer (Yanagawa et al, 1995;Wojciechowska-Lacka et al, 1996) and Hodgkin's lymphoma (Seymour et al, 1997).…”

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confidence: 99%

Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate

Wang

Chow

1999

Br J Cancer

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Recently, the serum level of interleukin (IL)-6 has been shown to correlate with disease progression and prognosis of cancer patients. However, the available information about the source and the pathophysiological regulation of IL-6 in cancer cells is limited. Thus, in this study, we tried to identify the source and the clinical roles of serum IL-6 in patients with oesophageal squamous cell carcinoma (ESCC), and then further to characterize the biological regulation of IL-6 in ESCC cell lines. Sera and tissue specimens from 80 consecutive patients with ESCC were collected between 1993 and 1997. Additionally, three ESCC cell lines were used for in vitro study. The concentration of serum IL-6 was measured by enzyme-linked immunosorbent assay (ELISA), and correlated the survival time with measured IL-6 level. Expressions of IL-6, IL-6Rα (IL-6 receptor alpha) and gp130 in pathological sections and cell lines were characterized by immunological staining. Detection of IL-6 mRNA was determined by in situ hybridization (ISH) and reverse transcription-polymerase chain reaction (RT-PCR). Up-regulation of IL-6 by n-sodium butyrate (n-BT) was studied in ESCC cell lines. The levels of serum IL-6 in patients with ESCC were significantly higher than those in the healthy controls. Serum levels of IL-6 were also shown to correlate with disease progression and survival. However, sCD8 levels and lymphocyte counts in the peripheral blood were not parallel to the changed pattern of serum IL-6. In pathological sections and ESCC cell lines, message of IL-6 was identified by ISH in cancer cells. Expression of IL-6 mRNA was further confirmed with RT-PCR in ESCC cell lines. Although IL-6 was detected in some ESCC cell lines, IL-6 gene expression and protein production could be induced or enhanced by n-BT treatment in all three cell lines. The serum levels of IL-6 are frequently elevated at diagnosis of ESCC, and are associated with poor prognosis. IL-6 that could be produced by cancer cells is up-regulated by n-BT. © 1999 Cancer Research Campaign

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Serum levels of interleukin-1, interleukin-6 and tumour necrosis factor-alpha in patients with gastric carcinoma

Cited by 66 publications

References 18 publications

Significance of Thrombocytosis in Clinicopathologic Characteristics and Prognosis of Gastric Cancer

Significance of Thrombocytosis in Clinicopathologic Characteristics and Prognosis of Gastric Cancer

Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer

Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate

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