Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer

Velikova, Galina; Banks, Rosamonde E.; Gearing, A. J. H.; Hemingway, Ian; Forbes, M A; Preston, Shaun R.; Jones, Mark; Wyatt, John P.; Miller, Keren; Ward, U.; Al-Maskatti, J; Singh, Shruti; Ambrose, N. S.; Primrose, JN; Selby, P.

doi:10.1038/bjc.1997.569

Cited by 57 publications

(27 citation statements)

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“…Our results extend these observations for patients with colorectal cancer and for the first time report elevated serum concentrations of VCAM-1 in colorectal cancer. This finding is in keeping with our previous observations of elevated VCAM-1 in patients with different gastrointestinal cancers and with gastric cancer, in particular, in which VCAM-1 concentrations seems to have independent prognostic significance (Banks et al, 1993;Velikova et al, 1997).…”

Section: Discussionsupporting

confidence: 93%

“…After observations of a strong correlation of circulating ICAM-1, VCAM-1, E-cadherin and E-selectin with serum alkaline phosphatase in patients with gastric cancer, we have suggested that soluble adhesion molecules might have a biliary route of excretion and their clearance might be impaired in the presence of intrahepatic cholestasis secondary to liver metastases (Velikova et al, 1997). In the colorectal cancer patients, the correlation between some soluble adhesion molecules and serum alkaline phosphatase is still present but not as strongly as in the gastric cancer patients.…”

Section: Discussionmentioning

confidence: 99%

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Serum concentrations of soluble adhesion molecules in patients with colorectal cancer

Velikova

Banks²,

Gearing³

et al. 1998

Br J Cancer

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Summary The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 48 patients with colorectal cancer before treatment, and their relation to clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence. and sites of metastatic disease, tumour pathology and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 wiare significantly elevated in the patients with colorectal cancer in comparison with a group of healthy subjects (P < 0.00001). Levels of circulating ICAM-1 and VCAM-1 were increased both in patients with local and those with metastatic disease. Although elevated in some patients soluble E-cadherin and E-selectin concentrations were not significantly elevated compared with the control group (P = 0.71 and P = 0.052 respectively). The levels of circulating ICAM-1 were significantly correlated with those of VCAM-1 and E-selectin. A correlation was also found between the serum concentrations of E-selectin and ICAM-1 and alkaline phosphatase, total white cell count and platelet count. VCAM-1 was positively correlated with age and negatively with degree of tumour differentiation and haemoglobin concentration. The biological implications and possible clinical relevance of these findings are discussed.Keywords: E-cadherin; E-selectin; intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1); adhesion molecule; colorectal cancer Cellular adhesion molecules play an important role in the process of metastasis. Positive and negative regulation of cell adhesion will influence the process as metastatic cells break away from the primary tumour, travel in the circulation and then adhere to cellular and extracellular matrix elements in particular secondary sites. Several families of cell adhesion molecules have been identified together with specific aberrations in malignant diseases (Zetter, 1993). The cadherins, Ca++-dependent homotypic cell-cell adhesion molecules, are essential for establishing and maintaining intercellular connections. Epithelial cadherin (E-cadherin) plays a crucial role in maintaining the integrity of epithelial tissues and has been positively correlated with tumour differentiation and negatively with infiltrative tumour growth and metastatic potential in a range of cancer types (Takeichi, 1993;Shino et al, 1995). Selectins are transmembrane glycoproteins that mediate heterotypic cell-cell contact through Ca+-dependent interactions with cell surface carbohydrates. In addition to mediating leucocyte adhesion to activated vascular endothelium, endothelial selectin (E-selectin) has been shown to be involved in the adhesion of cancer cells to the vasculature. Stronger adhesion to the endothelium is mediated through other classes of adhesion molecules, namely the integrins and cytokine-inducible endothelial cell adhesion molecules of the immunoglobuli...

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Serum concentrations of soluble adhesion molecules in patients with colorectal cancer

Velikova

Banks²,

Gearing³

et al. 1998

Br J Cancer

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“…31,32 This suggests that adhesion proteins can be released or shed, as opposed to exclusively being expressed on the cell surface after synthesis. We assayed the supernatant from these cells using either ELISA techniques or Western blotting.…”

Section: Icam-1 and Vcam-1 Proteins Are Present And Expressed On The mentioning

confidence: 99%

Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Regulated on Activation Normal T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil Adhesion and Activation

Ali¹,

Kaur

Patel

2000

The American Journal of Pathology

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Eosinophils are usually associated with parasitic and allergic diseases; however, eosinophilia is also observed in several types of human tumors, including breast carcinomas. In this study we examined several human breast carcinoma cell lines for adhesion mol- Eosinophils represent a minor fraction of the circulating leukocytes; however, they are key mediators in diseases such as bronchial asthma, allergic dermatitis, and helminthic parasite infections.

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“…VCAM-1 expression is prevalent in areas of neovascularization and inflammatory infiltrate in atherosclerotic plaques (11). A soluble form of VCAM-1 is known to be shed from VCAM-1 on the cell surface and up-regulated in some diseases, including chronic inflammatory diseases (12) and some cancers (13,14). Soluble VCAM-1 (sVCAM-1) 3 has also been reported to exhibit angiogenic activity in vivo through mediating endothelial cell chemotaxis activity (15).…”

mentioning

confidence: 99%

Synergistic Effect of TNF-α in Soluble VCAM-1-Induced Angiogenesis Through α4 Integrins

Nakao¹,

Kuwano²,

Ishibashi

et al. 2003

The Journal of Immunology

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In our present study we focused on soluble VCAM-1 (sVCAM-1)/α4 integrin-induced angiogenesis and found that this type of angiogenesis was mediated through p38 mitogen-activated protein kinase and focal adhesion kinase (FAK). HUVEC expressed both α4 and β1 integrins, and it was reported that expression of α4 integrin and its counterreceptor, sVCAM-1/VCAM-1, was enhanced in response to an inflammatory cytokine, TNF-α. In endothelial cells phosphorylation of p38 and FAK, but not that of extracellular signal-regulated kinase 1/2 was induced by sVCAM-1. Migration of endothelial cells was stimulated in response to sVCAM-1 at similar levels as those induced by vascular endothelial growth factor, and sVCAM-1-induced migration was almost completely blocked by neutralizing Ab against α4 integrin, by either an inhibitor of p38 (SB203580), or by adenovirus containing FAK-related nonkinase. sVCAM-1 also induced the formation of blood vessels in Matrigel plug assay in vivo, and this neovascularization was blocked by SB203580 or neutralizing Ab against α4 integrin. Moreover, we also confirmed that both TNF-α and sVCAM-1 could synergistically induce angiogenesis in the corneas of mice when each factor at used dose could not induce. This angiogenesis by TNF-α and sVCAM-1 was almost completely blocked by coadministration of SB203580 and also by neutralizing Ab against α4 integrin. These results suggest that sVCAM-1/α4 integrin induces angiogenesis through p38 and FAK signaling pathways.

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Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer

Cited by 57 publications

References 42 publications

Serum concentrations of soluble adhesion molecules in patients with colorectal cancer

Serum concentrations of soluble adhesion molecules in patients with colorectal cancer

Intercellular Cell Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, and Regulated on Activation Normal T Cell Expressed and Secreted Are Expressed by Human Breast Carcinoma Cells and Support Eosinophil Adhesion and Activation

Synergistic Effect of TNF-α in Soluble VCAM-1-Induced Angiogenesis Through α4 Integrins

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