Serum Levels of Insulin-like Growth Factor-I Are Related to Age and Not to Body Composition in Healthy Women and Men

O'Connor, Kieran G.; Tobin, Jordan D.; Harman, S. Mitchell; Plato, Chris C.; Roy, Tracey A.; Sherman, Sheryl S.; Blackman, Marc R.

doi:10.1093/gerona/53a.3.m176

Cited by 97 publications

(73 citation statements)

References 38 publications

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“…Our findings, taken together with results of previous studies obtained in mice with developmental liver-specific knockdown of IGF-1 (Lopez-Lopez et al 2004), suggest that circulating level of IGF-1 is a critical regulator of brain capillarity. These findings are clinically relevant as circulating IGF-1 levels significantly decrease with age in humans (Franco et al 2014;O'Connor et al 1998), and restoration of circulating IGF-1 in older laboratory animals was shown to significantly increase cerebromicrovascular density (Sonntag et al 1997).…”

Section: Discussionmentioning

confidence: 74%

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini

Tucsek

Valcarcel‐Ares

et al. 2016

AGE

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Strong epidemiological and experimental evidence indicate that both age and hypertension lead to significant functional and structural impairment of the cerebral microcirculation, predisposing to the development of vascular cognitive impairment (VCI) and Alzheimer's disease. Preclinical studies establish a causal link between cognitive decline and microvascular rarefaction in the hippocampus, an area of brain important for learning and memory. Age-related decline in circulating IGF-1 levels results in functional impairment of the cerebral microvessels; however, the mechanistic role of IGF-1 deficiency in impaired hippocampal microvascularization remains elusive. The present study was designed to characterize the additive/synergistic effects of IGF-1 deficiency and hypertension on microvascular density and expression of genes involved in angiogenesis and microvascular AGE (2016) 38:273-289

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Section: Discussionmentioning

confidence: 74%

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Tarantini

Tucsek

Valcarcel‐Ares

et al. 2016

AGE

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“…It is well-known that serum total IGF concentrations are related with age and several indices of physiological ageing such as body composition, strength, mobility and mortality (14,16,18,27,28). However, the measurement of IGF1 by immunoassay does not take the modifying effect of the IGFBPs on IGF1 action into consideration and therefore we found it relevant to compare total IGF1 and bioactive IGF1 in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…IGF1 is an important downstream mediator of the anabolic effects of GH and its serum levels are inversely correlated with age, with a small difference between sexes (16,17). Moreover, total IGF1 levels are associated with strength, mobility and mortality in women (18,19).…”

Section: Introductionmentioning

confidence: 99%

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Vestergaard

Hansen

Frystyk

et al. 2014

European Journal of Endocrinology

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Objective: Senescent changes in body composition and muscle strength are accompanied by reduced production of GH and IGF1, but the causal relationship remains elusive. We speculate that serum bioactive IGF1, measured by the IGF1 kinase receptor activation assay, is closer related to human physiological ageing than total IGF1 measured by immunoassay. Design: We conducted a cross-sectional study in 150 adult males and females, between 20 and 70 years. After an overnight fasting, serum levels of bioactive IGF1, total IGF1 and IGF-binding protein 1 (IGFBP1) and IGFBP3 were assessed. Furthermore, body composition and muscle strength was measured. Results: Total IGF1 levels were higher in females (PZ0.048). Bioactive IGF1 were identical in males and females (PZ0.31), decreasing with age. Total IGF1 tended to decrease more with age compared with bioactive IGF1 (K1.48 vs K0.89 percent/year, PZ0.052). Total body fat (TBF) was lower and BMI was higher in males (P!0.001 and PZ0.005), and both increased with age. Knee extension and elbow flexion force were higher in males (PZ0.001 and PZ0.001), but decreased with age in both genders.Total but not bioactive IGF1 was positively correlated to TBF, knee extension and muscle function in males. In multiple linear regression, only age predicted total IGF1, whereas age and IGFBP1 predicted bioactive IGF1. Conclusions: Bioactive IGF1 tends to decrease to a lesser extent than total IGF1 with age and was not correlated with measures of body composition or muscle strength. Therefore, levels of circulating bioactive IGF1 does not appear to be a better biomarker of physiological ageing than total IGF1.

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“…Greater muscle mass, testosterone and GH levels and the lesser propensity to dysregulation of the hypothalamicadrenal axis and cortisol secretion may protect males from physical decline (15)(16)(17)(18)(19). A distinctive age-related change in the immune system probably makes men more vulnerable to infections and less prone to chronic conditions which are ultimately responsible for muscle loss (20,21).…”

Section: Discussionmentioning

confidence: 99%

Relationship between the occiput-wall distance and physical performance in the elderly: a cross sectional study

et al. 2007

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Serum Levels of Insulin-like Growth Factor-I Are Related to Age and Not to Body Composition in Healthy Women and Men

Abstract: Advancing age, rather than declining serum levels of IGF-I, appears to be a major determinant of life-time changes in body composition and BMD in women and men.

Cited by 97 publications

References 38 publications

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging

Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults

Relationship between the occiput-wall distance and physical performance in the elderly: a cross sectional study

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