Serum levels of IL-8 and IL-6 in the long term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study

Pourfarzam, Shahryar; Ghazanfari, Tooba; Yaraee, Roya; Ghasemi, Hassan; Hassan, Zuhair Mohammad; Faghihzadeh, Soghrat; Ardestani, Sussan K.; Kariminia, Amina; Fallahi, Faramarz; Soroush, Mohammad Reza; Merasizadeh, Javad; Mahlojirad, Maryam; Naghizadeh, Mohammad Mehdi; Ghanei, Mostafa

doi:10.1016/j.intimp.2009.09.002

Cited by 56 publications

(42 citation statements)

References 43 publications

(53 reference statements)

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“…Serum levels of cytokines were determined using ELISA (8,13). Overall, IL-1α, IL-1β, IL-1Ra, IL-6 and TNF-α levels were significantly different between exposed and control groups, so that the level of these cytokines in the exposed group (Hospitalized (H) and Non-Hospitalized (NH)) was significantly lower than the control group (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Nadoushan¹,

Mahdavi²,

Soroush³

et al. 2016

Trauma Mon

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Background: Despite observed post Sulfur Mustard (SM) exposure hemolysis, serum bilirubin concentration does not significantly increase in SM-exposed casualties. The concentration of serum bilirubin can be related to serum levels of inflammatory cytokines. Objectives: In this study, the relationship between the serum levels of Interleukin (IL)-1α, IL-1β, IL-1Ra, Tumor Necrotizing Factor (TNF)-α and IL-6 with serum bilirubin concentration was investigated. Methods: Overall, 368 individuals, who were exposed to SM in 1986, and 127 non-exposed control participants were studied in the context of hematological factors, serum bilirubin and inflammatory cytokines. Total serum bilirubin and direct bilirubin were analyzed using an enzymatic method, while the inflammatory cytokines were evaluated by enzyme linked immunosorbent assay (ELISA). Results:The concentration of inflammatory cytokines in the exposed group was significantly different compared to the control group, however the serum concentrations of total and direct bilirubin did not differ between the two groups. Among cytokines, other than the relationship between the IL-6 concentrations and bilirubin level, there were no significant correlations between the levels of other cytokines with direct and total bilirubin. Conclusions: Considering the lack of correlation between bilirubin concentrations and levels of inflammatory cytokines other than IL-6, we should identify other confounding factors for lack of increase in bilirubin in SM casualties, despite the observed hemolysis.

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Section: Resultsmentioning

confidence: 99%

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Nadoushan¹,

Mahdavi²,

Soroush³

et al. 2016

Trauma Mon

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“…These cytokines, on their own, can evoke the release of IL-6 and IL-8 via autocrine or paracrine routes and thereby trigger an inflammatory response (Losa Garcia et al, 1999). There are proof-of-concept studies that clearly indicate a heightened state of inflammation in SM-intoxicated veterans, accompanied by increased pulmonary and systemic levels of IL-6 and IL-8, even 20 years post-exposure (Pourfarzam et al, 2009;Yaraee et al, 2009). Overall, it appears that counterbalancing the T H 1/T H 2 system in favor of T H 2 cytokines is an important underlying mechanism in the development of SMinduced inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

Panahi¹,

Ghanei²,

Vahedi³

et al. 2013

Journal of Immunotoxicology

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Pulmonary problems are among the most common chronic complications of sulfur mustard (SM) intoxication and adversely affect patients' quality-of-life. The present trial investigated the impact of immunotherapy with interferon (IFN)-g on quality-of-life, respiratory symptoms, and circulating immunologic and oxidative parameters in patients suffering from chronic SMinduced complications. Patients (n ¼ 15) were administered IFNg (100 mg) every other day for a period of 6 months. Assessment of quality-of-life [using St. George respiratory Questionnaire (SGRQ) and COPD Assessment Test (CAT) indices], the severity and frequency of respiratory symptoms, and serum levels of immunologic [including interleukin (IL)-2, IL-4, IL-6, IL-10, IFNg, calcitonin gene related peptide (CGRP), matrix metallopeptidase (MMP)-9, and tumor necrosis factor (TNF)-a], oxidative stress [malondialdehyde (MDA) as well as total and reduced glutathione, and catalase and superoxide dismutase (SOD) activity], and fibrogenic [transforming growth factor (TGF)-b] parameters were performed at baseline and at trial end. The results indicated that IFNg therapy is associated with improvements in SGRQ (p50.001) and CAT (p50.001) scores, decreased severity of cough (p ¼ 0.001), dyspnea (p50.001), and morning dyspnea (p50.001), reduced frequency of sputum production (p50.001) and hemoptysis (p50.001), and elevated FEV 1 (p ¼ 0.065). Serum levels of IL-4 (p50.001), IL-6 (p50.001), IL-10 (p50.001), CGRP (p50.001), MMP-9 (p ¼ 0.001), TNFa (p50.001), TGFb (p50.001) and MDA (p ¼ 0.001) were decreased while those of IL-2 (p50.001), IFNg (p50.001), and both total (p ¼ 0.005) and reduced glutathione (p ¼ 0.061) increased by the end of the trial. It was concluded that IFNg has favorable effects on the quality-of-life and alleviates respiratory symptoms in patients suffering from chronic SM-induced pulmonary complications. A modulation of cytokines and oxidative stress appears responsible for the clinical efficacy of IFNg.

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“…(3) It is necessary to interpret the differences in various studies on the level of cytokines. IL-6 was previously suggested as being an important cytokine in pulmonary disorders (Attaran et al, 2010;Pourfarzam et al, 2009). The carcinogenic role of SM as well as other mechanisms has been discussed by Ghanei & Harandi (2010).…”

Section: Dear Editormentioning

confidence: 99%

Comments on “Sulfur Mustard and Respiratory Diseases,” Tang & Loke (2012) and a prepared integrated mechanism for chronic pulmonary disease from exposure to sulfur mustard

Saburi

Ghanei

2013

Critical Reviews in Toxicology

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Serum levels of IL-8 and IL-6 in the long term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study

Cited by 56 publications

References 43 publications

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard

Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

Comments on “Sulfur Mustard and Respiratory Diseases,” Tang & Loke (2012) and a prepared integrated mechanism for chronic pulmonary disease from exposure to sulfur mustard

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