Serum Levels of Iap, Cea and Ca19-9 in Patients With Urological Malignancies

Iizumi, Takashi; Amemiya, Hiroshi; Hata, Ryosuke; Kaneko, Shunta; Muramatsu, Hiroshi; Kariba, Takeo; Toyoshima, Atsushi; Yazaki, Tsunetada; Waku, Masayoshi

doi:10.5980/jpnjurol1928.79.8_1448

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“…In their study of 64 cases of patients with urinary malignant tumors, Iizumi et al [5] reported that the serum CA19-9 level was not associated with the depth of invasion. These divergent opinions may be due to the difference in the number and composition of diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, cases of urothelial carcinoma displaying high serum CA19-9 levels have been reported sporadically, and investigators have begun studying the diagnostic significance of CA19-9 in the domain of urology as well [2][3][4][5]. Previously published reports deal with a small number of cases, but many of them have claimed that CA19-9 is useful for judging the effects of treatment and also for predicting prognosis after treatment.…”

Section: Introductionmentioning

confidence: 99%

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CA19-9 as a Serum Marker for Poor Prognosis in Urothelial Carcinoma

Sashide¹,

Isobe²,

Wakumoto³

et al. 2004

Urol Int

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Introduction: To evaluate the role of serum carbohydrate antigen 19-9 (CA19-9) in the prognosis and follow-up evaluation of patients with urothelial carcinoma, the authors studied the association of the serum level and positive rate with clinical features such as infiltration and metastasis in 164 patients admitted to the authors’ department. Patients and Methods: This study included 164 cases of patients with urohelial carcinoma. The absolute value of the serum CA19-9 level and its positive rate were tested. Simple variant analysis and logistic regression analysis were used for estimation of statistical significance. Kaplan-Meier’s test and Cox’s proportional hazard model were used for analysis of survival. Results: Significant differences in the serum CA19-9 levels were found with regard to the following parameters: the presence or absence of metastasis, clinical stage, depth of invasion, and degree of differentiation. The positive rate displayed a significant difference only for the presence or absence of metastasis. With regard to the presence of metastasis, serum CA19-9 was a significant risk factor along with depth of invasion in logistic regression analysis. Comparison of the survival rate indicated the prognosis to be significantly poor in the positive group and serum CA19-9 was regarded to be a prognostic risk factor in analysis via the regression model. Conclusions: Serum CA19-9 is thought to serve as a significant marker for advanced cancer and tumors with highly malignant potential and is useful for predicting prognosis of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%