“…They failed to seroconvert and to develop HBsAB while on reduced immunosuppression. This is not surprising since minimal immunosuppression was continued with corticosteroids which are known to decrease HBsAB titers in the serum [3], Immunosuppressive treatment favors virus replication in liver cells [3], Some authors have proposed, therefore, to reduce immunosuppression in order to improve the chance for virus elimination by minimizing the rate of virus replica tion [13,14]. However, following reduction of immuno suppression and recuperation of immunocompĂ©tence, necrosis of all infected liver cells may ensue [15,16].…”