Age‐Specific Prevalence of Hepatitis B e Antigen (HBeAg) and Antibody to HBeAg (Anti‐HBe) among Asymptomatic Hepatitis B Surface Antigen (HBsAg) Carriers in Okinawa and Kyushu, Japan

Kashiwagi, Seizaburo; Hayashi, Jun; Nomura, Hideyuki; Kajiyama, Wataru; Ikematsu, Hideyuki; Shingu, Toshimitsu; Hayashida, Kazuo; Kaji, Masahide

doi:10.1111/j.1348-0421.1986.tb02993.x

Cited by 11 publications

(11 citation statements)

References 33 publications

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“…We previously reported that there was a significant epidemiological difference in the clinical course of chronic HBV infection, even within one country such as Japan. Patients in Fukuoka had higher rates of HBeAg positivity and liver damage than those in Okinawa, and the former less frequently had HBeAg negativity than the latter 6,7 . This has been recognized as reflecting hepatitis B surface antigen (HBsAg) subtype, because HBsAg subtypes adr and adw are most common in Fukuoka and Okinawa, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Patients in Fukuoka had higher rates of HBeAg positivity and liver damage than those in Okinawa, and the former less frequently had HBeAg negativity than the latter. 6,7 This has been recognized as reflecting hepatitis B surface antigen (HBsAg) subtype, because HBsAg subtypes adr and adw are most common in Fukuoka and Okinawa, respectively. Also, the rates and ages of seroconversion from HBeAg to anti-HBe are higher and occur at a younger age in patients with HBsAg subtype adw than in those with adr.…”

Section: Introductionmentioning

confidence: 99%

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Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Nakashima¹,

Furusyo

Kubo³

et al. 2004

J of Gastro and Hepatol

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Nakashima¹,

Furusyo

Kubo³

et al. 2004

J of Gastro and Hepatol

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“…The results relative to the general distribution of serological markers of HBV in the total sample considered, particularly the prevalence of HBV-DNA, HBeAg and anti-HBe in asymptomatic carriers in Ethiopia show differences when compared with those from countries of similarly high levels of endemicity, such as the Middle East (21) and southeastern Asia (13,15,23).…”

Section: Discussionmentioning

confidence: 99%

“…This is also confirmed by the presence of high rates of reinfection, as it may be deduced by the presence of individuals with simultaneous positivity for HBsAg and anti-HBs and, in some cases, also for HBV-DNA. It appears that the prevalence of HBeAg-positive individuals in Ethiopia is lower than that in Asia (15,16,23), whereas that of anti-HBe is higher in comparable types of population and age (10). A faster seroconversion may therefore be hypothesized in African populations.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of HBeAg, anti-HBe serological markers and HBV-DNA in asymptomatic carriers in Ethiopia

Rapicetta

Hailu²,

Morace

et al. 1989

Eur J Epidemiol

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Data on the distribution of HBV-DNA and other serological markers of hepatitis B virus infection in a population of asymptomatic carriers in Ethiopia are reported. As compared to data from other countries of similar or lower levels of endemicity, it has been found that HBV-DNA prevalence and its correlation with HBeAg/anti-HBe status is similar to that of northern Europe. HBV-DNA is present in 84% of HBe Ag-positive sera but in only 4% of anti-HBe-positive sera, where the lowest concentration of DNA (less than 5 pgr/20 microliters) was found. The trend of increasing prevalence of serological markers with age seems to indicate a considerable horizontal transmission still present in this age range (18-30). In keeping with data of other authors a 3% of HBV-DNA positivity in anti HBc only positive sera was found. No regional or ethnical differences of HBV-DNA positive sera across the country were observed. There is also no evidence of any correlation between HBV-DNA prevalence and HBsAg subtypes ad and ay.

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Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: A prospective study

Nakayoshi

Maeshiro

Nakayoshi

et al. 2003

Journal of Medical Virology

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The factors contributing to the prognosis of hepatitis B virus (HBV)- related chronic liver disease were assessed prospectively in 72 patients with chronic hepatitis B confirmed clinically and pathologically. A comparative study was undertaken between patients infected with genotype B and those with genotype C. During the follow-up period, 13 (81.3%) of 16 patients with genotype B who were initially hepatitis B e antigen (HBeAg) positive became HBeAg negative and 14 (51.9%) of 27 with genotype C became HBeAg negative. HBeAg had been cleared in 8 (61.5%) of 13 patients with genotype B within the first 2 years of the follow-up, but in only one (7.1%) of 14 with genotype C (P < 0.05). Four (11.4%) of 35 patients with genotype B had progressed to cirrhosis, whereas, 12 (32.4%) of 37 patients with genotype C progressed to cirrhosis, including two patients with hepatocellular carcinoma. Multivariate analysis showed that difference in HBV genotype influenced significantly either the clearance of HBeAg or the development of cirrhosis. In conclusion, HBeAg was cleared from sera more frequently and earlier in patients with genotype B compared with those with genotype C, and development of cirrhosis occurred less frequently in patients with genotype B compared with those with genotype C. Thus, HBV genotypes may influence the prognosis of HBV-related chronic liver disease.

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Age‐Specific Prevalence of Hepatitis B e Antigen (HBeAg) and Antibody to HBeAg (Anti‐HBe) among Asymptomatic Hepatitis B Surface Antigen (HBsAg) Carriers in Okinawa and Kyushu, Japan

Abstract: A total of 1,741 asymptomatic hepatitis B surface antigen (HBsAg)

Cited by 11 publications

References 33 publications

Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Prevalence of HBeAg, anti-HBe serological markers and HBV-DNA in asymptomatic carriers in Ethiopia

Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: A prospective study

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