Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Nakashima, Hisashi; Furusyo, Norihiro; Kubo, Nobuhide; Kashiwagi, Kenichiro; Etoh, Yoshitaka; Kashiwagi, S; Hayashi, Jun

doi:10.1111/j.1440-1746.2003.03318.x

Cited by 17 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is probably because of the limited number of patients with genotype B infection in this study. Consistent with the previous reports on the literature [52][53][54][55], genotype C showed a much higher frequency of BCP mutation than genotype B. T1762/A1764 mutation occurred in 92.4% of genotype C and 37.5% of genotype B (P < 0.01). T1766 and A1768 were exclusively found in patients infected with genotype C. These data supported the hypothesis that the association between HBV genotype C and HCC was probably not genuine but was due to the high percentage of BCP mutation in patients with HBV genotype C infection [56].…”

Section: Discussionsupporting

confidence: 94%

Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China

Guo

Yan

Gao

et al. 2008

Journal of Hepatology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 94%

Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China

Guo

Yan

Gao

et al. 2008

Journal of Hepatology

View full text Add to dashboard Cite

“…The rate of HBe seroconversion following entecavir treatment for 3 years in this study (26%), is somewhat lower than previously reported for patients treated with adefovir or lamivudine for 3 years (40% and 43%, respectively) [24,33]. This may be related to the large proportion (92%) of HBV genotype C patients enrolled in this study, which has previously been associated with delayed HBe seroconversion [10,34].…”

Section: Number Of Patientscontrasting

confidence: 78%

“…The vast majority of CHB patients in Japan are infected with hepatitis B virus (HBV) of genotype C [6,7]. Infection with genotype C virus has been associated with delayed HBe seroconversion, more advanced liver disease, and increased probability of HCC development [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Long-term use of entecavir in nucleoside-naïve Japanese patients with chronic hepatitis B infection

Yokosuka

Takaguchi

Fujioka

et al. 2010

Journal of Hepatology

115

View full text Add to dashboard Cite

“…One prospective study has shown that patients with HBV genotype C infections are more likely to develop HCC 29 . The 1762 T /1764 A mutations have been reported to be more common in chronic HBV genotype C infections (76%) than in genotype B infections (7%) 30 . However, confirmation has not been reported nor have completely prospective studies been reported evaluating the risk associated with these two mutations.…”

Section: Cirrhosis As a Contributing Factor To Hccmentioning

confidence: 99%

Pathogenesis of hepatitis B virus‐associated hepatocellular carcinoma

Tabor

2007

Hepatology Research

View full text Add to dashboard Cite

Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) remains the most common form of HCC in large areas of Asia and Africa. It remains common even in some countries where hepatitis C virus (HCV)-associated HCC has become the predominant form, such as Japan. Integration of HBV in HCC DNA is found at random sites in the host genome in nearly all patients with HBV-associated HCC. It is not clear how often this integration results in insertional mutagenesis, but previously unknown growth regulating genes and cancer-associated genes have been found frequently near HBV integration sites in HCC in recent studies. In addition, HBV encodes a transactivating protein, the X protein, which could enable the randomly integrated HBV to alter the function of host genes that are not near the integration site. Mutations at two adjacent codons in HBV (1762(T)/1764(A) mutations) within the X gene are frequently found in HCC patients, and may play a role in the mutagenic or transactivational role of HBV in HCC. The presence of cirrhosis in most patients with HBV-associated HCC, and the presence of mutations in tumor suppressor genes in many, suggests that these are also factors in hepatocarcinogenesis. Few studies have examined the mutations of more than one gene in the same HCC patients. Fewstudies have evaluated the interactions between HBV mutations, host gene mutations, cirrhosis, and other potentially mutagenic stresses at the cellular level, with progression to HCC, and few studies have been conducted to determine whether these changes must accumulate in succession to lead to HCC. The recent availability of rapid sequencing methods and DNA microarray technologies has permitted expression profiling and permutation analysis of an array of genes to explore the pattern and succession of molecular changes leading to HBV-associated HCC. To date, these methods have been used to show patterns of molecular changes that differ in HBV-associated HCC (compared to HCV-associated HCC or to HCC in patients lacking either virus) and patterns that can predict survival (and hence may directly indicate different mechanisms of disease), and may soon make possible a universally accepted clinical classification scheme for HCC.

show abstract

Double point mutation in the core promoter region of hepatitis B virus (HBV) genotype C may be related to liver deterioration in patients with chronic HBV infection

Abstract: Genotype C might be one of the worse prognostic markers in patients with chronic HBV infection, possibly because of mutation in the CP region.

Cited by 17 publications

References 41 publications

Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China

Sequential accumulation of the mutations in core promoter of hepatitis B virus is associated with the development of hepatocellular carcinoma in Qidong, China

Long-term use of entecavir in nucleoside-naïve Japanese patients with chronic hepatitis B infection

Pathogenesis of hepatitis B virus‐associated hepatocellular carcinoma

Contact Info

Product

Resources

About