Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency

Abstract

Abstract. The aim of the present study is to investigate possible alterations in ghrelin and other hormone levels related to appetite and somatic growth in children with iron deficiency anemia. Twenty-five patients and 25 healthy controls that were prepubertal and within normal limits regarding height and BMI standard deviation scores were recruited. Ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol levels were studied. Ghrelin, insulin and IGF-I levels were significantly low in the study group (ghrelin 13.58 ± 16.32 vs. 35.39 ± 23.69 ng/ml, p<.001; insulin 3.41 ± 2.42 vs. 5.67 ± 1.09 mU/ml, p = .008 and IGF-I 126.94 ± 92.82 vs. 203 ± 105.1 ng/ml, p = .015). We concluded that low ghrelin and insulin levels might be causes of the appetite loss in iron deficiency and as a result of appetite loss and undernutrition as well as by direct effects they might be related with growth retardation, which could be also influenced by low IGF-I levels.

Hormonal Alterations in Prepubertal Children with Iron Deficiency

“…The study "Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency" authored by İsgüven et al was published in Endocrine Journal in 2007 [1]. We read the article with great interest.…”

The relationship between serum ghrelin levels and bone metabolism markers and severity anemia in non-diabetic hemodialysis patients; a pilot study

“…In the study of Firczyk et al, the average duration of hemodialysis in the hemodialysis with diabetic nephropathy group was 28 months and in the hemodialysis patients without nephropathy was 25 months (19). Furthermore, in the study by Isguven et al in 2007, among the children suffering from iron deficiency anemia, the ghrelin levels were significantly lower than the control group, but no clear association between the ghrelin levels and their blood parameters was found (17). In our study, the ghrelin levels of non-diabetic hemodialysis patients showed a positive and not significant correlation with their hemoglobin levels.…”

“…Ayala et al reported a significant relationship between the baseline serum levels of ghrelin and serum insulin levels, body mass index (BMI), abdominal fat and serum leptin levels (16). Furthermore, Isguven et al studied ghrelin levels in children suffering from anemia and reported that ghrelin level was significantly lower than normal individuals (17). In another study on menopausal women, the serum ghrelin levels were found to be lower than non-menopausal healthy individuals with a significant relationship between serum ghrelin and bone density (18).…”

Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

“…Further more recently, Isguven et al [6] and Akarsu et al [7] reported that total ghrelin decreased with IDA and concluded that appetite loss in iron deficiency is a result of decrement of appetite hormone ghrelin [6,7].…”

“…Further studies showed that obestatin was also involved in inhibiting thirst, improving memory, and affecting cell proliferation (reviewed [24]). As indicated above, ghrelin and obestatin might play crucial role or roles in a quite diverse range of physiologic functions in diseases, including IDA Since it has been shown that ghrelin decreased in children with IDA, it was concluded that loss of appetite was a result of decreased ghrelin [6,7]. However, both groups in those studies [6,7], they measured only total ghrelin in children with IDA and did not follow up by iron supplementation, whereas appetite stimulation could be achieved with acylated ghrelin [21].…”