Hormonal Alterations in Prepubertal Children with Iron Deficiency

Kılıç, Nermin; Aydın, Süleyman; Barim, Abdullah Önder

doi:10.1507/endocrj.k08e-336

Cited by 2 publications

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“…Ghrelin is found in 2 major forms as acylated or desacylated in biological fluid [7]. Both forms need to be studied, especially acylated form because it is the active form of ghrelin [7, 29]. In addition to total ghrelin in the serum, the changes in the contents of acylated ghrelin were detected previously as well in the present study.…”

Section: Discussionsupporting

confidence: 72%

Ghrelin is Negatively Correlated with Iron in the Serum in Human and Mice

et al. 2017

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Background/Aims: The studies in the patients with iron deficiency anemia (IDA) implied the existence of the association of ghrelin with iron or hepcidin levels in the plasma under the pathophysiological conditions. We hypothesized that fasting may be able to affect iron metabolism via ghrelin under the physiological conditions. Methods: We investigated the effects of fasting on serum ghrelin and iron contents in healthy volunteers (23–31 years) and C57BL/6 male mice (8-week-olds) under the physiological conditions. Results: Fasting induced a significant elevation in both total ghrelin and acylated ghrelin and a reduction in iron levels in the serum of both human and mice. Correlation analysis demonstrated that total ghrelin or acylated ghrelin is negatively correlated with iron in the serum in human and mice. Conclusion: Ghrelin has a role to reduce serum iron under the conditions of fasting.

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Section: Discussionsupporting

confidence: 72%

Ghrelin is Negatively Correlated with Iron in the Serum in Human and Mice

et al. 2017

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Reply to Kilic et al.

İşgüven

2009

Endocr J

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We respect the critic done by Kilic et al.[1] related to our recent paper published in Endocrine Journal [2]. However, we would like to state that we do not agree with Kilic et al. on their views on the methodology and the reasoning. We used Phonix Ghrelin (Human) RIA Kit. This assay recognizes both acylated and desacylated forms of ghrelin. There are numerous studies reported in the literature using the method that we followed in our study [3][4][5].Regarding the units and serum levels of ghrelin, we are very sorry to share our mistake which is pg/tube values given us by the laboratory were expressed as pg/ ml in the text unless being multiplied before by ten (one tube is 100 microliter). ng/ml in the abstract is a spelling error.We apologize for the mistake.

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Hormonal Alterations in Prepubertal Children with Iron Deficiency

Cited by 2 publications

References 3 publications

Ghrelin is Negatively Correlated with Iron in the Serum in Human and Mice

Ghrelin is Negatively Correlated with Iron in the Serum in Human and Mice

Reply to Kilic et al.

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