Serum levels of cytokeratin‐18 (tissue polypeptide‐specific antigen) in liver diseases

Gonzalez-Quintela, Arturo; Mallo, Nieves; Mella, C; Campos, Joaquín; Pérez, Luis‐Fernando; López-Rodríguez, Raimundo; Tomé, Santiago; Otero, Esteban

doi:10.1111/j.1478-3231.2006.01380.x

Cited by 31 publications

(33 citation statements)

References 21 publications

(41 reference statements)

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“…All markers were also tested for correlations against serum creatinine, bilirubin, transaminases, and C-reactive peptide (CRP) levels. High levels of TPS were associated to high levels of transaminases, which is well in line with previous reports [22]. No other correlations could be observed for the conventional or the stromal derived tumour markers.…”

Section: Correlation Between Circulating Tumour Markerssupporting

confidence: 92%

Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma

Franklin

Öhlund

Lundin

et al. 2015

CBM

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Naredi, P. et al. (2015) Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma.Cancer Biomarkers, 15 (1) Abstract. BACKGROUND: A lack of disease-specific symptoms and good tumour markers makes early detection and diagnosis of pancreatic ductal adenocarcinoma (PDAC) challenging. OBJECTIVE: To analyse the tissue expression and circulating levels of four stroma-derived substances (type IV collagen, endostatin/type XVIII collagen, osteopontin and tenascin C) and four conventional tumour markers (CA 19-9, TPS, CEA and Ca 125) in a PDAC cohort. METHODS: Tissue expression of markers in normal pancreas and PDAC tissue was analysed with immunofluorescence. Plasma concentrations of markers were measured before and after surgery. Patients with non-malignant disorders served as controls. RESULTS: The conventional and stromal substances were expressed in the cancer cell compartment and the stroma, respectively. Although most patients had increased levels of many markers before surgery, 2/12 (17%) of patients had normal levels of Ca 19-9 at this stage. High preoperative endostatin/type XVIII collagen, and postoperative type IV collagen was associated with short survival. Neither the pre-nor postoperative levels of TPS, Ca 125 or CA 19-9 were associated to survival. CONCLUSIONS: PDAC is characterized by an abundant stroma. These initial observations indicate that the stroma can be a source of PDAC tumour markers that are found in different compartments of the cancer, thus reflecting different aspects of tumour biology.

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Section: Correlation Between Circulating Tumour Markerssupporting

confidence: 92%

Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma

Franklin

Öhlund

Lundin

et al. 2015

CBM

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“…Similar findings have been reported for TPA, TPS, and CYFRA in nonsmall cell lung cancers (44). However, these markers have somewhat limited clinical utility because of their lack of organ specificity and elevated serum levels in some nonmalignant diseases; for example, high CYFRA levels accompany interstitial pulmonary fibrosis (45), and high TPS levels are found in the context of several liver disorders (46). Additional data are needed to establish the clinical utility of serum SEK measurements in malignant disorders and the relative potential interference from nonmalignant diseases.…”

Section: Seks As Serum Markers Of Tissue Injury Epithelial Cancers supporting

confidence: 63%

Toward unraveling the complexity of simple epithelial keratins in human disease

Omary¹,

Ku²,

Strnad³

et al. 2009

J. Clin. Invest.

242

357

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Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and include keratin 7 (K7), K8, K18-K20, and K23. Genetically engineered mice that lack SEKs or overexpress mutant SEKs have helped illuminate several keratin functions and served as important disease models. Insight into the contribution of SEKs to human disease has indicated that K8 and K18 are the major constituents of Mallory-Denk bodies, hepatic inclusions associated with several liver diseases, and are essential for inclusion formation. Furthermore, mutations in the genes encoding K8, K18, and K19 predispose individuals to a variety of liver diseases. Hence, as we discuss here, the SEK cytoskeleton is involved in the orchestration of several important cellular functions and contributes to the pathogenesis of human liver disease.

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“…The most commonly used markers are tissue polypeptide antigen (TPA; a mixture of CK8, CK18, and CK19), tissue polypeptide-specific antigen (TPS; derived from CK18), cytokeratin fragment 21-1 (CYFRA 21-1; derived from CK19) (Leers, Kolgen et al 1999;Marceau, Schutte et al 2007). High TPS levels have been reported in several liver disorders (Gonzalez-Quintela, Mallo et al 2006). …”

Section: Ck As Serum Markers and Ck Variants In Liver Diseasesmentioning

confidence: 99%

Cytokeratins of the Liver and Intestine Epithelial Cells During Development and Disease

Chougule¹,

Sumitran–Holgersson²

2012

Cytokeratins - Tools in Oncology

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Serum levels of cytokeratin‐18 (tissue polypeptide‐specific antigen) in liver diseases

Abstract: Serum TPS (cytokeratin-18) is elevated in patients with non-malignant liver diseases, particularly in those with prominent cytolysis. Further studies are needed to evaluate the use of TPS as a marker of liver disease.

Cited by 31 publications

References 21 publications

Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma

Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma

Toward unraveling the complexity of simple epithelial keratins in human disease

Cytokeratins of the Liver and Intestine Epithelial Cells During Development and Disease

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