Serum levels of adiponectin and vitamin D correlate with activity of Rheumatoid Arthritis

Khajoei, Sholeh; Hassaninevisi, Maryam; Kianmehr, Nahid; Seif, Farhad; Khoshmirsafa, Majid; Shekarabi, Mehdi; Samei, Azam; Haghighi, Anousheh

doi:10.1007/s11033-019-04682-1

Cited by 20 publications

(13 citation statements)

References 42 publications

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“…Adiponectin is a secretion of adipose tissue and plays an important role in regulating the inflammatory response in inflammation (Tsatsanis et al, 2005;Fantuzzi, 2008). Some observational studies showed that serum adiponectin levels were significantly higher in RA patients compared with healthy controls (Alkady et al, 2011;Khajoei et al, 2019). In contrary, a case-control study documented that plasma adiponectin levels were significantly lower in RA patients compared with healthy controls in Chinese population (Zhao et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study

Chen

Zhu

et al. 2021

Front. Genet.

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Background: Accumulating evidence from observational studies suggested that circulating adiponectin levels are associated with the risk of rheumatoid arthritis (RA), but the causality remains unknown. We aimed to assess the causal relationship of adiponectin with RA risk.Methods: Based on summary statistics from large-scale genome-wide association studies (GWAS), we quantified the genetic correlation between adiponectin and RA. Then bidirectional Mendelian randomization (MR) analysis was performed to assess the causal relationship. Twenty single-nucleotide polymorphisms (SNPs) associated with adiponectin were selected as instrumental variables from a recent GWAS (n = 67,739). We applied theses SNPs to a large-scale GWAS for RA (14,361 cases and 43,923 controls) with replication using RA data from the FinnGen consortium (6,236 cases and 147,221 controls) and the UK Biobank (5,201 cases and 457,732 controls). The inverse-variance weighted (IVW) and multiple pleiotropy-robust methods were used for two-sample MR analyses.Results: Our analyses showed no significant genetic correlation between circulating adiponectin levels and RA [rG = 0.127, 95% confidence interval (CI): –0.012 to 0.266, P = 0.074]. In MR analyses, genetically predicted adiponectin levels were not significantly associated with the RA risk (odds ratio: 0.98, 95% CI: 0.88–1.09, P = 0.669). In the reverse direction analysis, there is little evidence supporting an association of genetic susceptibility to RA with adiponectin (β: 0.007, 95% CI: –0.003 to 0.018, P = 0.177). Replication analyses and sensitivity analyses using different models yielded consistent results.Conclusions: Our findings provided no evidence to support the causal effect of adiponectin levels on RA risk and of RA on circulating adiponectin levels.

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Section: Discussionmentioning

confidence: 99%

No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study

Chen

Zhu

et al. 2021

Front. Genet.

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“…Lee et al conducted a meta-analysis of the sensitivity of vitamin D levels to RA and RA activity in rheumatoid patients, indicating that vitamin D levels were negatively correlated with sensitivity to RA and RA activities (33). There are also studies based on rheumatoid arthritis that suggest that active vitamin D can be used as a parameter for regulating inflammation and that vitamin D has the potential to be a therapeutic biomarker and can even be used to track the disease progression and treatment effect of rheumatoid arthritis patients (34). In previous systematic reviews, no studies have evaluated VD as a supplement for the treatment of RA.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D Supplementation on Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis

et al. 2020

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Objective Observational studies have shown that vitamin D levels are inversely related to rheumatoid arthritis activity, yet evidence from population interventions remains inconsistent.Methods: The PubMed, Cochrane Library, Embase, CNKI, VIP, and Wanfang databases were searched for studies published before June 2020. Information was collected about the pain visual analog scale (VAS), Disease Activity Score 28 (DAS28), serum vitamin D level, tender joint count (TJC), swollen joint count (SJC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and parathyroid hormone (PTH) research data.Results: Six studies (n = 438) were included in the meta-analysis. Vitamin D supplementation resulted in a significant improvement in the DAS28 (weighted mean difference (WMD) = −0.41, 95% CI (−0.59, −0.23), P < 0.001), ESR (WMD = −3.40, 95% CI (−6.62, −0.18), P = 0.04) and TJC (WMD = −1.44, 95% CI (−2.74, −0.14), P = 0.03) but not in other outcomes. According to the subgroup analyses, VAS and serum vitamin D were improved in the European ethnic subgroups. TJC and serum vitamin D were improved in the Asian ethnic subgroups. TJC and serum vitamin D were improved in the duration ≤ 12 w subgroups, and the VAS and DAS28 in the duration > 12 w subgroup were different from those of the control group. With a vitamin D dose ≤50,000 IU, only serum vitamin D and TJC improved, and with a vitamin D dose> 50,000 IU, the VAS and DAS28 improved.Conclusions: Compared with placebo control interventions, vitamin D supplementation seemed to be an effective intervention for patients with rheumatoid arthritis. Different doses of vitamin D and durations of intervention produce different effects.

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“…A Artrite Reumatoide (AR) é uma doença autoimune sistêmica do tecido conjuntivo, caracterizada pela inflamação das articulações sinoviais; na qual numerosas células e mediadores solúveis inflamatórios estimulam estas inflamações crônicas e aumentam a gravidade da doença (KHAJOEI et al, 2019), causando significante morbidade e diminuindo a expectativa de vida. Esta doença atinge 0,3 a 1,0% da população geral, sendo mais prevalente entre mulheres e em países desenvolvidos (CHAUDHARI, RIZVI;SYED, 2016).…”

Section: Artrite Reumatoideunclassified

Implications of Vitamin D Insufficiency/Deficiency in Autoimmune Diseases: A Review

Alves¹,

Cesilio²,

Alves³

et al. 2021

Rev. UNINGÁ

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A vitamina D é um hormônio esteroide lipossolúvel com amplitude de efeitos biológicos que extrapolam a regulação do metabolismo do cálcio e da saúde óssea, que alcança preponderante papel na manutenção da homeostase sistêmica, relacionado ao crescimento, diferenciação e apoptose celular, regulação dos sistemas imunológico, cardiovascular e muscular e ao metabolismo da insulina; além de participar da modulação direta ou indireta de cerca de 3% do genoma humano. Frente o exposto, e considerando as graves complicações advindas da deficiência de vitamina D para a saúde e qualidade de vida, propôs-se neste trabalho um estudo descritivo, o qual relaciona a insuficiência/deficiência desta vitamina a algumas doenças autoimunes como o lúpus eritematoso sistêmico, o diabetes mellitus, a esclerose múltipla, a artrite reumatoide e a doença inflamatória intestinal (Doença de Crohn). Este estudo foi desenvolvido a partir de 58 artigos, dentre os quais incluem os de revisão, artigos originais de pesquisas clínicas e experimentais, publicados entre 2008 a 2020, obtidos a partir da pesquisa no banco de dados Pubmed®, Google Acadêmico e Scientific Electronic Library Online (SCIELO). Com base nos estudos relacionados às doenças autoimunes, pode-se concluir que a vitamina D exibe função imunomoduladora crucial, garantindo eficiente sistema de proteção. Estudos que versam sobre a suplementação de vitamina D, tanto para a prevenção quanto para o tratamento das doenças autoimunes existentes são necessários e de grande valia para o entendimento dessas implicações.

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Serum levels of adiponectin and vitamin D correlate with activity of Rheumatoid Arthritis

Cited by 20 publications

References 42 publications

No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study

No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study

The Effect of Vitamin D Supplementation on Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis

Implications of Vitamin D Insufficiency/Deficiency in Autoimmune Diseases: A Review

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