No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study

Chen, Hanzhu; Mi, Shuai; Zhu, Jiahao; Jin, Weidong; Li, Yasong; Wang, Tianle; Li, Yingjun; Fan, Chunhong

doi:10.3389/fgene.2021.670282

Cited by 13 publications

(20 citation statements)

References 36 publications

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“…The studies included in this review are from Italy [ 13 ], Egypt [ 14 , 15 , 16 ], Unites States [ 17 , 18 ], Mexico [ 19 , 20 , 21 , 22 ], Sweden [ 23 , 24 ], China [ 25 , 26 , 27 ], Turkey [ 28 ], and Finland [ 29 ]. One study was multicentered [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…The included clinical studies were conducted to evaluate the roles of several different organokines in RA. These organokines were adiponectin [ 18 , 23 , 29 , 30 ], chemerin [ 14 , 19 , 20 , 29 ], leptin [ 18 , 23 , 25 , 29 , 31 ], resistin [ 23 , 29 , 32 ], visfatin [ 23 , 29 ], vaspin [ 15 ], omentin [ 15 ], fibroblast growth factor 21 [ 17 , 18 ], osteoprotegerin [ 16 ], osteocalcin [ 16 ], fibrinogen-like protein 1 [ 17 ], sex hormone-binding globulin [ 18 ], myostatin [ 19 ], and irisin [ 15 , 16 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…A role of omentin against RA is that this adipokine can successfully decrease activation of Janus kinase 2/STAT3 (JAK-2/STAT3) pathways, which reduces inflammation and decreases MMP (metalloproteinase) production. To date, the roles that omentin exerts in rheumatic diseases are still unclear, and further researches are necessary to truly evaluate this adipokine in RA pathophysiology and progression [ 14 , 105 , 107 , 108 , 109 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

“…Besides MMP-3, other degradation-related molecules can be produced by chondrocytes stimulated by chemerin among RA patients, such as the C-C motif ligand 2 (CCL2). Combining inflammation and angiogenesis in RA pathophysiology, chemerin also stimulates motility and migration of immune and fibroblast cells to the joints, augmenting cartilage degradation [ 14 , 19 , 20 , 107 , 113 , 114 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

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Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. Organokines can produce beneficial or harmful effects in this condition. Among RA patients, organokines have been associated with increased inflammation and cartilage degradation due to augmented cytokines and metalloproteinases production, respectively. This study aimed to perform a review to investigate the role of adipokines, osteokines, myokines, and hepatokines on RA progression. PubMed, Embase, Google Scholar, and Cochrane were searched, and 18 studies were selected, comprising more than 17,000 RA patients. Changes in the pattern of organokines secretion were identified, and these could directly or indirectly contribute to aggravating RA, promoting articular alterations, and predicting the disease activity. In addition, organokines have been implicated in higher radiographic damage, immune dysregulation, and angiogenesis. These can also act as RA potent regulators of cells proliferation, differentiation, and apoptosis, controlling osteoclasts, chondrocytes, and fibroblasts as well as immune cells chemotaxis to RA sites. Although much is already known, much more is still unknown, principally about the roles of organokines in the occurrence of RA extra-articular manifestations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

See 2 more Smart Citations

Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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“…Some studies reported increased plasma levels of adiponectin in RA patients, which correlated positively with the parameters of disease activity, clinical symptoms, and progression of joint erosions and also correlated with the expression of other mediators involved in inflammation, severity of joint destruction, and response to treatment [ 15 , 21 , 22 , 23 , 24 ]. Other studies have not found elevated plasma adiponectin concentrations in RA patients [ 25 , 26 ], or even a negative correlation between adiponectin concentrations and disease activity parameters [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Is a Component of the Inflammatory Cascade in Rheumatoid Arthritis

Łączna

Kopytko

Tkacz

et al. 2022

JCM

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Adiponectin is a secretory protein of adipocytes that plays an important role in pathological processes by participation in modulating the immune and inflammatory responses. The pro-inflammatory effect of adiponectin is observed in rheumatoid arthritis (RA). In this study, we examined adiponectin plasma levels and the expression of adiponectin in bone marrow tissue samples, synovium samples, and infrapatellar fat pad samples from patients with osteoarthritis (OA) and RA. Additionally we examined the expression of adiponectin receptors AdipoR1 and AdipoR2 in synovium samples and infrapatellar fat pad samples from patients with OA and RA. We also assessed the correlations between adiponectin plasma concentrations, adiponectin expression in bone marrow, synovium, infrapatellar fat pad, and plasma levels of selected cytokines. We found increased expression of adiponectin in synovium samples and infrapatellar fat pad samples from patients with RA as compared to patients with OA. There were no statistically significant differences of adiponectin plasma levels and adiponectin expression in bone marrow tissue samples between OA and RA patients. There were no differences in the expression of AdipoR1 and AdipoR2 at the mRNA level in synovial tissue and the infrapatellar fat pad between RA and OA patients. However, in immunohistochemical analysis in samples of the synovial membrane from RA patients, we observed very strong expression of adiponectin in intima cells, macrophages, and subintimal fibroblasts, such as synoviocytes, vs. strong expression in OA samples. Very strong expression of adiponectin was also noted in adipocytes of Hoffa’s fat pad of RA patients. Expression of AdipoR1 was stronger in RA tissue samples, while AdipoR2 expression was very similar in both RA and OA samples. Our results showed increased adiponectin expression in the synovial membrane and Hoffa’s pad in RA patients compared to that of OA patients. However, there were no differences in plasma adiponectin concentrations and its expression in bone marrow. The results suggest that adiponectin is a component of the inflammatory cascade that is present in RA. Pro-inflammatory factors enhance the expression of adiponectin, especially in joint tissues—the synovial membrane and Hoffa’s fat pad. In turn, adiponectin also increases the expression of further pro-inflammatory mediators.

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Anxiety disorder and cardiovascular disease: a two‐sample Mendelian randomization study

Peng,

Meng,

Guo

et al. 2024

ESC Heart Failure

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AimsCardiovascular disease is the leading cause of death worldwide. Anxiety disorders are common psychiatric conditions associated with cardiovascular outcomes. This two‐sample Mendelian randomization (MR) study investigated the causal relationship between anxiety disorders and coronary heart disease (CHD), myocardial infarction (MI), heart failure (HF), and atrial fibrillation (AF).MethodsSingle nucleotide polymorphisms (SNPs) associated with anxiety disorders (16 730 cases; 101 021 controls) were obtained from the UK Biobank genome‐wide association study (GWAS). Cardiovascular outcome data were derived from the FinnGen study (CHD: 21 012 cases and 197 780 controls; MI: 12 801 cases and 187 840 controls; HF: 23 397 cases and 194 811 controls; and AF: 22 068 cases and 116 926 controls). Inverse variance weighted (IVW), MR–Egger, weighted median, simple mode, and weighted mode analyses examined causality.ResultsIVW analysis demonstrated significant causal relationships between anxiety disorders and increased risk of CHD [odds ratio (OR): 4.496; 95% confidence interval (CI): 1.777–11.378; P = 0.002], MI (OR: 5.042; 95% CI: 1.451–17.518; P = 0.011), and HF (OR: 3.255; 95% CI: 1.461–7.252; P = 0.004). No relationship was observed with AF (OR: 1.775; 95% CI: 0.612–5.146; P = 0.29). Other methods showed non‐significant associations. Two‐way analysis indicated no reverse causality.ConclusionsAnxiety disorders were causally associated with greater risk of CHD, MI, and HF but not AF among individuals of European descent. Further research on mediating mechanisms and in diverse populations is warranted.

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No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study

Cited by 13 publications

References 36 publications

Organokines in Rheumatoid Arthritis: A Critical Review

Organokines in Rheumatoid Arthritis: A Critical Review

Adiponectin Is a Component of the Inflammatory Cascade in Rheumatoid Arthritis

Anxiety disorder and cardiovascular disease: a two‐sample Mendelian randomization study

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