Serum levels of adiponectin and IGFBP‐1 in short children born small for gestational age

Kamoda, Tomohiro; Nozue, Hiroki; Matsui, Akira

doi:10.1111/j.1365-2265.2006.02724.x

Cited by 13 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study by Cianfarani et al ., 15 serum adiponectin levels were found low in short SGA children, and were inversely related to postnatal CUG and fasting insulin levels. In a recent study by Kamoda et al ., 18 similar hypoadiponectinaemia has been shown in short SGA subjects. In the study by Lopez et al ., 16 adiponectin levels in short SGA children were similar to AGA children and were inversely related to BMI.…”

Section: Discussionsupporting

confidence: 54%

“…Adiponectin, an anti‐inflammatory peptide released from fat cells promotes insulin sensitivity and hypoadiponectinaemia has been associated with insulin resistance in animal and human studies 13 . However, limited number of studies on adiponectin levels in SGA born prepubertal children have revealed conflicting levels, either low or normal or even high in the face of hyperinsulinaemia 14–18 . Insulin‐like growth factor binding protein‐1 (IGFBP‐1) has been advocated as a marker of insulin resistance in obese children, 19 but IGFBP‐1 levels have varied in SGA children in different studies, either reduced 20 or similar 21 when compared to normal children.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insulin, adiponectin, IGFBP‐1 levels and body composition in small for gestational age born non‐obese children during prepubertal ages

Sancakli

Darendelıler²,

Baş³

et al. 2008

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Insulin, adiponectin, IGFBP‐1 levels and body composition in small for gestational age born non‐obese children during prepubertal ages

Sancakli

Darendelıler²,

Baş³

et al. 2008

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…The most notable findings are the inverse association between IGF‐I and hsCRP and the positive association of IGFBP‐1 with adiponectin. The previous limited reports correlating IGFBP‐1 with adiponectin have not, to our knowledge, included investigation in obese adolescents and have not controlled for confounding factors such as BMI and insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents

et al. 2014

View full text Add to dashboard Cite

Context Insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 have been linked to cardiovascular disease (CVD) risk and pathophysiology in adults, but there are limited data in youth. Objective The aim of the study was to examine the relationship between IGF and IGFBP-1 with traditional and non-traditional CVD risk factors including inflammatory markers and body composition in an obese pediatric cohort. Design A cross-sectional study. Setting The study was carried out at a university children’s hospital. Subjects Sixty-one obese non-diabetic adolescents. Outcomes Fasting IGF-I, IGFBP-1, lipoprotein profiles, high-sensitivity C-reactive protein (hsCRP), and total adiponectin as well as insulin sensitivity measures, blood pressure (BP), and anthropometrics. Results IGFBP-1 was negatively associated with insulin sensitivity measures, body mass index (BMI), and diastolic BP in males. IGF-I was negatively associated with hsCRP (r = −0.479, p < 0.0005), and IGFBP-1 was positively associated with adiponectin (r = 0.545, p < 0.0005). The IGF-I/CRP and IGFBP-1/adiponectin associations remained significant when controlling for both BMI and insulin sensitivity index (SI). Both IGF-I and IGFBP-1 were negatively associated with waist circumference (r = −0.327 and r = −0.275, respectively) and sagittal abdominal diameter (r = −0.333 and r = −0.371, respectively), while IGFBP-1 was negatively associated with fat mass (r = −0.347, p = 0.01) as well as neck circumference and fat-free mass in males. Controlling for BMI z-score and SI, IGFBP-1 remained negatively associated with diastolic blood pressure (r = 0.706, p = 0.001 and neck circumference (r = −0.548, p = 0.15) in males. Conclusions IGF-I and IGFBP-1 associate with CVD risk markers and may add to clinical assessments of cardiometabolic dysfunction in youth.

show abstract

“…Reduced serum IGFBP-1 levels are considered to reflect hyperinsulinemia and cardiovascular risk in adults and obese children [32,34]. Kamoda T et al reported that the levels of serum IGFBP-1 were similar in short children born SGA and AGA [35]. Kistner A et al investigated the serum markers of insulin resistance in adults born SGA and reported that lower IGFBP-1 and triglyceride levels were observed in the SGA group compared to the AGA group despite with normal BMI [36].…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age

Deng

et al. 2012

Nutr Metab (Lond)

View full text Add to dashboard Cite

AbstractsBackground and objectiveThe study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA)Subjects and methodsWe recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I (with BMI catch-up) and II (without BMI catch-up) respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height. Their serum fasting insulin, fasting glucose, insulin-like growth factor-1, adiponectin, IGFBP-1, triglyceride concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) were evaluated.Results(1) The HOMA-IR values in SGA-I with catch-up growth group were significantly higher than those in SGA-II with catch-up growth, SGA-I without catch-up growth and AGA children respectively. (2) The serum adiponectin levels of individuals in the SGA-I without catch-up growth and SGA-II with catch-up growth groups were significantly lower than those from the SGA-II without catch-up growth group. There was no difference in triglyceride or IGFBP-1 levels among the groups. (3) The degree of HOMA-IR was positively correlated with age, current BMI and △height SDS in SGA children.ConclusionThe development of insulin resistance and lower levels of adiponectin were closely correlated with higher BMI and the postnatal height catch-up growth in SGA children.

show abstract

Serum levels of adiponectin and IGFBP‐1 in short children born small for gestational age

Cited by 13 publications

References 36 publications

Insulin, adiponectin, IGFBP‐1 levels and body composition in small for gestational age born non‐obese children during prepubertal ages

Insulin, adiponectin, IGFBP‐1 levels and body composition in small for gestational age born non‐obese children during prepubertal ages

Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascular disease biomarkers in obese adolescents

Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age

Contact Info

Product

Resources

About