Serum levels of activin A and inhibin A are not related to the increased susceptibility to pre‐eclampsia in type I diabetic pregnancies

Abstract

Serum concentrations of activin A and inhibin A could not predict preeclampsia in type I diabetes.

Obstetric Nephrology

“…As in pre-eclampsia in nondiabetic women, pre-eclampsia in women with type 1 diabetes is also associated with elevated levels of antiangiogenetic factors in the third trimester (27). However, the function of placenta in the early stage of pregnancy judged by the level of activin A and inhibin A is often well preserved in diabetic women developing pre-eclampsia (42). Similarly, growth restriction of the fetus is rare in diabetic women with pre-eclampsia (42).…”

“…We suggest that the increased prevalence of pre-eclampsia in women with type 1 diabetes complicated with diabetic nephropathy or microalbuminuria is mainly related to maternal constitutional factors with an increased susceptibility to endothelial activation (28), whereas poor placentation is not a major pathogenetic factor (42). The pathogenesis of development of pre-eclampsia in women with diabetic nephropathy or microalbuminuria and type 1 diabetes does thus include presence of endothelial dysfunction (28), impaired maximal vasodilation (28), increased levels of prorenin a component of the RAS (36), and markers of cardial overload (41).…”

Electrochemical-surface enhanced Raman spectroscopy (E-SERS) of uric acid: a potential rapid diagnostic method for early preeclampsia detection

“…6,7 As a result, most diagnostic tests for preeclampsia are based on blood pressure and urine protein measurements; however, these tests often only work for late stage preeclampsia, and can be timeconsuming and expensive, both of which present barriers for routine implementation in developing nation settings. [8][9][10][11][12][13][14][15] As a result, there is a need for new diagnostic tests for preeclampsia that are rapid, portable, affordable, and which take advantage of new/more sensitive biomarkers. Such rapid diagnostic tests will allow for detection of preeclampsia at an early stage, where medical intervention may alter the course of progression.…”

Genetic markers for prediction of early and late onset preeclampsia in pregnant women with preexisting type 1 diabetes mellitus

“…Так, по мнению отдельных авторов, нарушения плацентации и провоцируемый ими дисбаланс ангиогенных и антиангиоген-ных факторов, представляющие собой осно-ву современных представлений о патогенезе преэклампсии, по всей видимости, не играют ведущей роли у пациенток с предсуществую-щими формами СД [32]. Это подтверждается целым рядом фактов: сохраненной функци-ей плаценты в ранние сроки беременности у большинства пациенток с СД, у которых в по-следующем развилась преэклампсия, а также достаточно редким сочетанием преэклампсии с синдромом задержки роста плода в данной группе женщин [21]. Напротив, считается, что такие факторы, как эндотелиальная дисфунк-ция, нарушенная способность сосудистой стенки к вазодилатации [18], повышенные кон-центрации проренина [41], а также маркеров перегрузки сердечной мышцы (предсердного натрийуретического пептида) [42] имеют ре-шающее значение в развитии преэклампсии у беременных с предсуществующим СД.…”