Serum Leptin Might Be Causally Correlated to Invasive Ductal Breast Carcinoma

Al-Shibli, Saad M.; Amjad, Nasser Muhammad; Al-Kubaisi, Muna Khaleel Dheyab; Harun, Norra; Nafie, Emad M.; Mizan, Shaikh

doi:10.4172/2324-9110.1000211

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“…In our previous study among Malaysian population that includes different races, a significant difference in leptin level was found between Malay and Chinese. The mean leptin level was 24.45 ng/ml for the Malay and 15.87 ng/ml for the Chinese [33] .…”

Section: Introductionmentioning

confidence: 89%

Co-expression of Leptin and Leptin Receptor in Adenocarcinoma of the Colon in Malay Population

Al-Shibli

Harun

Al-Kubaisi

2020

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Objectives: To assess the role of leptin in human colonic adenocarcinoma and to establish its expression in Malay population patients by using immunohistochemistry study. Methodology: Immunohistochemical study (IHC) using antibodies against leptin and its receptor was applied to assess the expression of leptin and its receptor in 38 samples of adenocarcinoma of the colon among Malay population and compare this expression with that of the adjacent normal colon tissue. Results: All the 38 colon adenocarcinoma samples stained strongly (100%) for leptin and 36 out of 38 also stained strongly for leptin receptor (95%). The other 2 (5%) stained weak (1+). However, the whole specimens of the normal adjacent colon tissue stained weakly (1+) for both leptin and leptin receptor. The expression of both hormones in cancer and normal tissue is significantly different (p<0.01). There was significant co-expression of both hormones in colonic cancerous tissue. Conclusions: Leptin/leptin receptor system may have a tumorigenic effect on the colon tissue, most likely by an autocrine process. Inhibition of leptin/leptin receptor system might be helpful in the prevention and management of colon cancer.

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Section: Introductionmentioning

confidence: 89%