Serum Leptin Levels in Patients with Premature Ejaculation

Atmaca, Murad; Kuloğlu, Murat; Tezcan, Ertan; Semerciöz, Atilla; Üstündağ, Bilal; Ayar, Ahmet

doi:10.1080/01485010290099192

Cited by 30 publications

(32 citation statements)

References 15 publications

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“…This observation corroborates studies describing no effect on leptin serum levels after treatment with citalopram or ESC 22,23). It is possible that a reduction can only be observed in populations with increased leptin levels, such as described for premature ejaculation 24). This would, at least indirectly, be in line with animal studies, in which a novel serotonin-reuptake inhibitor 3-me-thoxy-N-p-tolylquinoxalin-2-carboxamide (QCM-4) attenuated HPA axis hyperactivity in an obese mouse model of MDD by reversing increased plasma leptin 37).…”

Section: Discussionsupporting

confidence: 89%

“…No changes in leptin serum levels have been observed following 8 weeks of citalopram treatment in 14 depressed and 18 non-depressed women 23). In contrast, forty patients with premature ejaculation, a syndrome recently linked to increased leptin serum levels, demonstrated a reduction in serum levels after eight weeks of citalopram treatment 24). An acute increase of cortisol serum levels in healthy volunteers has been observed following oral citalopram administration 25,26).…”

Section: Introductionmentioning

confidence: 99%

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Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Frase

Doerr

Feige

et al. 2018

Clin Psychopharmacol Neurosci

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ObjectiveThe primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans.MethodsEleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed.ResultsA repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonstrated a significant reduction of ghrelin levels after AMI in comparison to PLA, and a significant reduction of cortisol levels after AMI in comparison to both ESC and PLA. Other contrasts did not reach statistical significance.ConclusionAdministration of a single dose of AMI, but not of ESC, leads to a significant reduction in morning serum ghrelin and cortisol levels. No effects on leptin and prolactin levels were observed. The differential impact of AMI and ESC on hormones might contribute to different adverse effect profiles of both substances.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Frase

Doerr

Feige

et al. 2018

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

show abstract

“…The growing number of studies have focused on the leptin levels in the various psychiatric disorders recently [3][4][5][6]. Leptin administration has reduced food intake and weight [7,8], suggesting its role on weight regulation.…”

Section: Introductionmentioning

confidence: 99%

Weight Gain and Serum Leptin Levels in Patients on Lithium Treatment

Atmaca¹,

Kuloğlu²,

Tezcan³

et al. 2002

Neuropsychobiology

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Weight gain is a frequent adverse effect associated with lithium use. Leptin is an adipocyte hormone, regulating food intake and energy balance providing the hypothalamus with information on the amount of body fat. Therefore, we planned to evaluate whether lithium administration was associated with weight gain, and leptin levels. The study consisted of 15 consecutive inpatients with bipolar I disorder according to DSM-III-R. The fasting serum leptin levels were measured. The patients were evaluted at baseline and at the eighth week according to the body mass index, weight, Young Mania Rating (YMRS) and Hamilton Depression Rating (HAM-D) scales, and serum leptin levels. With respect to the leptin levels, a significant difference was observed after lithium treatment. There was a significant positive correlation between the changes in leptin levels and the duration of illness. The change in total YMRS scores correlated with change in leptin levels and that in weight. In conclusion, our result suggest that leptin may be associated with lithium-induced weight gain.

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“…A recognized relationship also exists between the leptinergic and serotonergic systems in the central nervous system. Results from a recent clinical trial have demonstrated a negative correlation between leptin levels and intravaginal ejaculatory latency time (IELT), as well as a positive correlation between leptin levels and the duration of PE [20]. The study, however, was conducted using only 15 male subjects with PE and 15 healthy controls.…”

Section: What Causes Pe?mentioning

confidence: 94%

Treatment of premature ejaculation: New drugs and treatment strategies

Heintz¹

2006

Curr sex health rep

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This review discusses treatment options for men with premature ejaculation (PE), a common sexual dysfunction characterized by short ejaculatory latency, decreased sexual satisfaction, and distress. For a number of reasons, including embarrassment and the belief that PE is a normal part of aging, that it has no effective treatment, or that it will resolve itself, few men with PE seek treatment. Although several treatment options exist (eg, behavioral, cognitive, and sex therapy methods; desensitizing drugs; off-label use of antidepressants, phosphodiesterase type 5 inhibitors, or α-blockers), the majority of men with PE are not satisfied with their results. New pharmacologic drugs develped specifically for the treatment of PE are undergoing evaluation in clinical trials. For example, recent clinical research studies have revealed on-demand administration of one such drug, dapoxetine, which achieved significant improvements in ejaculatory latency, control over ejaculation, and satisfaction with sexual intercourse. In addition, partners of men who received dapoxetine likewise reported improved satisfaction with sexual intercourse. Future studies may reveal that integration of pharmacologic drugs with psychologic and/or behavioral therapy techniques may be the optimal approach to the management of PE. PE is a treatable condition, and new drugs in development may provide benefits over those available.

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Serum Leptin Levels in Patients with Premature Ejaculation

Cited by 30 publications

References 15 publications

Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Weight Gain and Serum Leptin Levels in Patients on Lithium Treatment

Treatment of premature ejaculation: New drugs and treatment strategies

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