Serum leptin is associated with serum uric acid concentrations in humans

Fruehwald‐Schultes, Bernd; Peters, Achim; Kern, Werner; Beyer, J.; Pfützner, Andreas

doi:10.1016/s0026-0495(99)90163-4

Cited by 89 publications

(66 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Insulin may enhance renal urate reabsorption via stimulation of urate-anion exchanger URAT1 (22) and/or the Na ϩ -dependent anion cotransporter in brush border membranes of the renal proximal tubule (8). Additionally, because serum levels of leptin and urate tend to increase together (23,24), some investigators have suggested that leptin may affect renal reabsorption (8). Finally, in insulin resistance syndrome, impaired oxidative phosphorylation may increase systemic adenosine concentrations by increasing the intracellular levels of coenzyme A esters of long-chain fatty acids (8).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey

Choi¹,

Ford²,

Li³

et al. 2007

Arthritis & Rheumatism

411

216

View full text Add to dashboard Cite

Objective. To determine the prevalence of metabolic syndrome among patients with gout and to examine the association between the 2 conditions in a nationally representative sample of US adults. Methods. Using data from 8,807 participants age >20 years in the Third National Health and Nutrition Examination Survey (1988 -1994), we determined the prevalence of metabolic syndrome among individuals with gout and quantified the magnitude of association between the 2 conditions. We used both the revised and original National -4.61), respectively. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower, whereas the corresponding odds ratios were slightly higher. The stratified prevalences of metabolic syndrome by major associated factors of gout (i.e., body mass index, hypertension, and diabetes) remained substantially and significantly higher among those with gout than those without gout (all P values <0.05). Conclusion. These findings indicate that the prevalence of metabolic syndrome is remarkably high among individuals with gout. Given the serious complications associated with metabolic syndrome, this frequent comorbidity should be recognized and taken into account in long-term treatment and overall health of individuals with gout.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey

Choi¹,

Ford²,

Li³

et al. 2007

Arthritis & Rheumatism

411

216

View full text Add to dashboard Cite

show abstract

“…22) There is only one preliminary report in the literature on the relationship between leptin and uric acid concentrations. 23) In the background of emerging links between leptin, adiposity, hypertension, and insulin, we considered that alterations in serum leptin concentrations might be independently associated with serum uric acid levels. …”

mentioning

confidence: 99%

Leptin Might be a Regulator of Serum Uric Acid Concentrations in Humans

et al. 2003

View full text Add to dashboard Cite

SUMMARYIncreased serum urate concentration is a frequent finding in patients with hypertension. Since hyperuricemia is associated with obesity, renal disease, hyperlipidemia, and atherosclerosis, whether or not serum urate is a cardiovascular risk factor per se has remained elusive.The subjects were 210 Turkish male and 210 female adults over 20 years of age. None had diabetes mellitus, endocrine diseases, or renal or hepatic disease, and those receiving antihypertensive drugs, systemic corticosteroids, or lipid-lowering drugs were excluded. Height, weight, blood pressure, serum glucose, lipid profiles, serum insulin, DHEA-SO 4 , and leptin were measured in the morning after an overnight fast.Women had significantly higher mean leptin (20.3 ± 0.88 ng/mL vs 5.78 ± 0.39 ng/ mL, P < 0.001) and lower mean uric acid (248.03 ± 4.76 µmol/L vs 311.6 ± 5.35 µmol/ L, P < 0.001), triglyceride (1.42 ± 0.06 mmol/L vs 1.61 ± 0.06 mmol/L, P < 0.001), and DHEA-SO 4 (3.02 ± 0.17 µmol/L vs 4.43 ± 0.19 µmol/L, P < 0.001) concentrations than men, even when adjusted for BMI. On univariate correlation analysis, leptin showed the strongest association with BMI in both sexes and also correlated significantly with BMI, insulin, uric acid, glucose, total cholesterol, and triglycerides in males and BMI, insulin, uric acid, total cholesterol, apo B, and creatinine in females after adjustment for age and BMI. A statistical model containing creatinine, leptin, insulin, and triglycerides accounted for 34% of the variance in serum uric acid levels in men, whereas another consisting of creatinine, triglycerides, leptin, SBP, and insulin explained 42% of the variance in serum uric acid in women. The present study suggests that leptin could be one of the possible candidates for the missing link between obesity and hyperuricemia. Our study may also suggest that hyperuricemia is not only a metabolic end product but also a marker of a major pressor or pathogenic mechanism underlying the hypertension in obesity. (Jpn Heart J 2003; 44: 527-536)

show abstract

“…44 It has also been suggested that leptin (a cytokine produced by fat adipcytes) may provide a link between adiposity and SUA. 45 Leptin levels are higher in individuals with high SUA, 46 as well as in females. 47,48 Furthermore, women seem to show resistance to the lipostatic action of leptin, 47 suggesting that leptin may, in part, explain some of the sex differences.…”

Section: Discussionmentioning

confidence: 95%

Impact of different adiposity measures on the relation between serum uric acid and blood pressure in young adults

et al. 2011

View full text Add to dashboard Cite

Serum uric acid (SUA) concentration is independently associated with blood pressure (BP) in adults. We examined this association in young adults at an age where anti-hypertension treatment, other potential confounding factors and co-morbidity are unlikely to occur. We assessed BP, anthropometric variables including weight, height, waist circumference (WC), body fat percent (using bioimpedance), lifestyle behaviors, SUA and blood lipids in 549 participants aged 19-20 years from a population-based cohort study (Seychelles Child Development Study). Mean (s.d.) SUA was higher in males than females, 0.33 (0.08) and 0.24 (0.07) mmol l À1 , respectively. Body mass index (BMI) was higher in females than males but BP was markedly higher in males than in females. SUA was associated with both systolic and diastolic BP. However, the magnitude of the linear regression coefficients relating BP and SUA decreased by up to 50% upon adjustment for BMI, WC or body fat percent. The association between SUA and BP was not altered upon further adjustment for alcohol intake, smoking, triglycerides or renal function. In fully adjusted models, SUA remained associated with BP (Po0.05) in females. In conclusion, adiposity substantially decreased the association between SUA and BP in young adults, and BP was independently associated with SUA in females. These findings suggest a role of adiposity in the link between hyperuricemia and hypertension.

show abstract

Serum leptin is associated with serum uric acid concentrations in humans

Cited by 89 publications

References 11 publications

Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey

Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey

Leptin Might be a Regulator of Serum Uric Acid Concentrations in Humans

Impact of different adiposity measures on the relation between serum uric acid and blood pressure in young adults

Contact Info

Product

Resources

About