Serum leptin and ultrasound markers of early atherosclerosis in patients with sleep apnea hypopnea syndrome

Is obstructive sleep apnea a risk factor for lung cancer?—from pathophysiological mechanisms to clinical data

“…Although the relationship between OSA and some cardiovascular ( 5 - 8 ) and metabolic ( 9 , 10 ) adverse outcomes is well known, only during the last decade various studies of a pathophysiological nature, as well as murine and clinical models (both in epidemiological and clinical series) have established a relationship between OSA ( 11 , 12 ) and sleep duration ( 13 ) and a higher prevalence, incidence or aggressiveness of some malignant tumors. It seems that this relationship is more pronounced in more severe OSA (greater number of sleep-disordered breathing events, such as apneas, hypopneas), as well as in certain histological lines of tumor cells such as melanoma, bladder, liver, cervix, kidney, pancreas and lung cancer ( 14 , 15 ).…”