Is obstructive sleep apnea a risk factor for lung cancer?—from pathophysiological mechanisms to clinical data

Martínez-García, Miguel Ángel; Oscullo, Grace; Gómez-Olivas, Jose Daniel; Inglés-Azorin, Marina; Mompeán, Sergio

doi:10.21037/atm-23-1641

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the exact mechanisms linking OSA and lung cancer remain to be fully elucidated, the evidence suggests that intermittent hypoxia—a hallmark feature of OSA—may play a crucial role in tumorigenesis 10 , 18 . Intermittent hypoxia can lead to oxidative stress, DNA damage, and systemic inflammation, creating an environment conducive to cancer development and progression via hypoxia-inducible factor 5 , 19 . Additionally, OSA-related sleep fragmentation may further exacerbate carcinogenesis by increasing sympathetic activation, systemic inflammation, and immune dysregulation 3 , 20 .…”

Section: Discussionmentioning

confidence: 99%

Association of obstructive sleep apnea with risk of lung cancer: a nationwide cohort study in Korea

Cho,

2024

Sci Rep

View full text Add to dashboard Cite

Current knowledge regarding the relationship between obstructive sleep apnea (OSA) and the risk of lung cancer is limited. This study aimed to evaluate associations between OSA and the incidence of lung cancer based on the Korean National Health Information Database. The study outcome was the incidence of newly diagnosed lung cancer, and a Cox proportional hazards model was used for analysis. A total of 181,070 adult patients newly diagnosed with OSA between 2011 and 2018 were matched with those without OSA by up to 1:5 propensity score matching based on age and sex. During follow-up over (mean ± standard deviation) 9.1 ± 2.0 years, 2614 incident cases of lung cancer were identified. The incidence rate was 39.51 per 100,000 person-years in the OSA group, and 24.93 per 100,000 person-years in the control group. After adjusting for income and the presence of comorbidities, the association remained significant (hazard ratio [HR] 1.95, 95% confidence interval [CI] 1.74–2.18, p-value < 0.001). The adjusted HR for incident lung cancer was 2.14 (95% CI 1.69–2.70) in female patients with OSA, and 1.90 (95% CI 1.67–2.16) in male patients with OSA. The risk of incident lung cancer increased with age, with a HR of 2.99 (95% CI 2.46–3.64) in those aged ≥ 65 years. This nationwide study showed an independent association between OSA and an increased risk of lung cancer in the Korean population.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of obstructive sleep apnea with risk of lung cancer: a nationwide cohort study in Korea

Cho,

2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Recent studies seem to demonstrate that not all tumours are related to IH-related OSA, although melanoma is the most studied and apparently the most consistent in presenting this association in the various studies [ 8 ]. Furthermore, a focus on the relationship between OSA and lung cancer led to the discovery of other alternative pathophysiological pathways not necessarily associated with the hyperexpression of HIF-1α, but sometimes related to other immune cell deficiencies or dysfunction, biomarkers and genetic factors, and even changes in the microbiome [ 9 ].…”

mentioning

confidence: 99%

Linking obstructive sleep apnoea and lung cancer: a further step down the road

Martinez-Garcia

2024

ERJ Open Res

View full text Add to dashboard Cite

Extract Although the relationship between obstructive sleep apnoea (OSA) and its main pathophysiological consequence, intermittent hypoxaemia (IH), with cardiovascular, neurocognitive and metabolic diseases has been studied since the 1980s, the first studies on OSA's relationship with an increase in the prevalence, incidence and aggressiveness of cancer date back less than 15 years ago. In 2007, A brams [1] was the first to introduce the hypothesis of a potential relationship between cancer and OSA through the resulting hypoxaemia that the author christened “the hypoxia connection”. It was only a decade ago, however, that studies first began to be carried out in murine and human models on large populations or clinical series [2–6].

show abstract

Is obstructive sleep apnea a risk factor for lung cancer?—from pathophysiological mechanisms to clinical data

Cited by 2 publications

References 23 publications

Association of obstructive sleep apnea with risk of lung cancer: a nationwide cohort study in Korea

Association of obstructive sleep apnea with risk of lung cancer: a nationwide cohort study in Korea

Linking obstructive sleep apnoea and lung cancer: a further step down the road

Contact Info

Product

Resources

About