Serum Leptin and Cholesterol Values in Suicide Attempters

Atmaca, Murad; Kuloğlu, Murat; Tezcan, Ertan; Üstündağ, Bilal; Geçici, Ömer; Firidin, Burak

doi:10.1159/000054950

Cited by 93 publications

(55 citation statements)

References 19 publications

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“…Comparisons of suicide attempters to well controls have yielded similar results (Gallerani et al, 1995;Alvarez et al, 1999;Sarchiapone et al, 2000;Atmaca et al, 2002b;Kim et al,, 2002;Tripodianakis et al, 2002;Lee and Kim, 2003). Some have found the association between low cholesterol and suicide attempts to be strongest among those with violent suicide attempts or with a history of such attempts (Alvarez et al, 2000;Bocchetta et al, 2001;Atmaca et al, 2003b;Vevera et al, 2003;Kim and Myint, 2004;Marcinko et al, 2005).…”

Section: Introductionmentioning

confidence: 84%

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Fiedorowicz

Coryell

2007

Psychiatry Research

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Low cholesterol levels have commonly been associated with various suicide measures. We sought to examine suicide attempts in a prospective sample of depressed patients that on prior analysis demonstrated an association between low cholesterol and subsequent suicide completions. Seventyfour inpatients with Research Diagnostic Criteria unipolar major depression, bipolar depression or schizoaffective depression entered a prospective follow-up study from 1978 -1981. Kaplan-Meier survival analysis and Cox regression were utilized to elucidate the relationship between cholesterol levels and subsequent severe suicide attempts as well as all suicide attempts regardless of severity. Attempts preceding index hospitalization and other lifetime attempts were evaluated crosssectionally. Low serum cholesterol levels did not predict subsequent suicide attempts. Contrary to our hypothesis, the high cholesterol group was associated with increased risk of suicide attempts on survival analysis in those less than median age. Nonetheless, in cross-sectional analysis, the low cholesterol group had more suicide attempts preceding index hospitalization and more remote lifetime attempts. The results from this prospective dataset do not support an association between low cholesterol and subsequent suicide attempts despite replicating the retrospective findings of previous case-control and cross-sectional studies.

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Section: Introductionmentioning

confidence: 84%

Cholesterol and suicide attempts: A prospective study of depressed inpatients

Fiedorowicz

Coryell

2007

Psychiatry Research

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“…With larger sample sizes, two research groups demonstrated that plasma leptin levels were decreased in patients with major depression independent of body mass status [21,22]. Also, lower levels of leptin in cerebrospinal fluid were found in suicide attempters with depression than those without depression [23,24]. Moreover, decreased levels of leptin in plasma were observed in patients with bipolar disorder [25] and obsessive-compulsive disorder with comorbid major depression [26].…”

Section: Human Studiesmentioning

confidence: 99%

The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Lü

2007

Current Opinion in Pharmacology

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196

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SummaryThe adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

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“…Leptin is a fat cell-derived hormone signaling to the hypothalamus about food intake, the regulation of weight, and sexual behavior [14] and has been discovered by Zhang et al [21] as the product of the ob gene. A growing number of studies have focused on the leptin levels in the various psychiatric disorders recently [3,4,11]. An interaction between leptinergic and serotonergic systems in central nervous system has been observed [13].…”

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confidence: 99%