Serum leptin and adiponectin levels in children with type 1 diabetes mellitus – Relation to body fat mass and disease course

Majewska, Katarzyna Anna; Majewski, Dominik; Skowrońska, Bogda; Stankiewicz, Witold; Fichna, Piotr

doi:10.1016/j.advms.2015.10.002

Cited by 18 publications

(16 citation statements)

References 22 publications

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“…Serum resistin concentrations was decreased in fasting T1DM children and adolescents and has a negative correlation with body fat mass, which was not observed in healthy children. These findings might be the result of broken physiological adipo-insular regulations in T1DM children, independent of disease duration, its metabolic control, and insulin supply [33]. The decreasing lean mass in our T1DM patient treated at least 2 years with insulin has been demonstrated in other clinical situations with hyperinsulinism as in myotonic dystrophy [34,35].…”

Section: Discussionsupporting

confidence: 58%

Dual X-ray absorptiometry body composition and its associated factors in children and adolescence with type 1 diabetes mellitus in South of Iran, a case-control study

Saki

Dabbaghmanesh

2016

Int J Diabetes Dev Ctries

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To date, limited studies have been conducted for evaluation of the body composition with the dual X-ray energy absorptiometry (DEXA) method in children with type 1 diabetes mellitus (T1DM). Also, there are lack of data about factors associated with body composition parameters in T1DM children. This case-control study was performed on T1DM children whom had referred to Diabetes Clinics of Shiraz University of Medical Sciences, 2013-2014. Weight, height, physical activity, sun exposure, insulin regimen, and the Tanner stage of children were recorded by a trained physician. Serum lipids and glycemic tests were assessed. Body composition was assessed by the DEXA Hologic system. Statistical analysis was carried out using SPSS 18.0 software. Eighty-seven T1DM children (39 male and 48 females) and 87 age-and sex-matched healthy controls with a mean age of 12.4 ± 4.2 years were enrolled in this study. Fat mass index was more in T1DM (P = 0.012), and lean mass index was more in non-diabetic children (P = 0.013). The android/ gynecoid fat ratio in T1DM children was less than that of controls (P = 0.002). On multiple regression analysis, there was an independent effect of Tanner stage (P < 0.001) and FBS (P = 0.045) on total fat, an independent positive effect of age onset of T1DM (P < 0.001) on total lean mass. This study revealed an increase in the body fat index and a decrease in the lean mass index in T1DM children.

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Section: Discussionsupporting

confidence: 58%

Dual X-ray absorptiometry body composition and its associated factors in children and adolescence with type 1 diabetes mellitus in South of Iran, a case-control study

Saki

Dabbaghmanesh

2016

Int J Diabetes Dev Ctries

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“…The body mass index (BMI) of patients is considered as an important indicator to the severity of the disease . Adipocytes in the body can produce adipokines, adiponectin, and leptin, which may be related to the pathogenesis of asthma . To investigate the pathogenesis of asthma in children, the correlations of asthma in children with BMI, adiponectin, and leptin were mainly investigated in this study.…”

Section: Introductionmentioning

confidence: 99%

Correlations of severity of asthma in children with body mass index, adiponectin and leptin

Wang

Xue

2019

Clinical Laboratory Analysis

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BackgroundThis study aims to investigate the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin.MethodsA total of 122 children with asthma in our hospital from January 2017 to February 2018 were randomly selected and divided into control group (normal) and observation group (BMI > 28 kg/m2) according to BMI. BMI, adiponectin, and leptin levels between the two groups were measured and compared, and correlations of disease grade with BMI, adiponectin, or leptin were analyzed. Moreover, risk factors for asthma in children were also identified.ResultsBody mass index, leptin level, forced vital capacity (FVC), FVC%, and forced expiratory volume in 1s (FEV1)/FVC in observation group were significantly higher than those in control group (P < 0.05), while the adiponectin level, forced expiratory capacity in 1s (FEC1), and FEV1% in observation group were significantly lower than those in control group (P < 0.05). The amount of severe patients in observation group was much larger than that in control group. The severity of disease was positively correlated with BMI and leptin and negatively correlated with adiponectin. BMI, adiponectin, and leptin were identified as risk factors for asthma in children.ConclusionAdiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment.

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“…These results have clear clinical implications in humans: although studies have yielded both positive (12-16) and negative results (17-19) regarding an association of leptin with glycemic control in normoglycemic or mildly hyperglycemic T1D patients, patients in diabetic ketoacidosis (DKA) clearly have lower plasma leptin concentrations than healthy controls (20, 21). These results suggest that leptin may be regulated by insulin, an interpretation bolstered by the fact that leptin production by adipocytes rises with increasing insulin concentrations in vitro (22), during the acute treatment of DKA in T1D subjects (20) and during acute and chronic hyperinsulinemia in some studies in healthy controls (23-25).…”

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confidence: 99%

Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes

Perry

2017

PDJ

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Recent studies have demonstrated that leptin can prolong life chronically in rats with poorlycontrolled type 1 diabetes (T1D). Multiple explanations have been proposed to explain leptin's chronic antihyperglycemic effect, including suppression of glucagon release and/or signaling, reductions in hyperphagia and ectopic lipid content, and improvements in insulin sensitivity; it is leptin's ability to reduce plasma glucose relies on all of these effects. In addition, leptin reverses hyperglycemia and diabetic ketoacidosis (DKA) acutely, within 6 hours of leptin infusion, by suppressing hypothalamic-pituitary-adrenal (HPA) axis activity in insulinopenic rats. Thus current evidence suggests that leptin's acute, insulin-independent effect to reverse DKA by suppressing HPA axis activity occurs through a different mechanism from its chronic, pleotropic, insulindependent effect to reverse hyperglycemia and prolong survival in rodents with T1D. Leptin may therefore represent an attractive therapeutic target to improve glycemic control in humans with poorly-controlled T1D. Keywordstype 1 diabetes; leptin; corticosterone; diabetic ketoacidosis; hypothalamic-pituitary-adrenal axis Type 1 diabetes (T1D) occurs when T-cell mediated destruction of the insulin-producing β-cell (1, 2) leads to insulinopenia, hyperglycemia, and ketoacidosis, which can rapidly result in coma and death if left untreated. For reasons that remain unclear, the incidence of T1D is on the rise worldwide (3, 4), and increases in diabetic ketoacidosis (DKA) rates have accompanied the increasing prevalence of T1D (5, 6). For eight decades since its discovery in the early 1920s, insulin was believed to be the only hormone capable of reversing T1D, and consequently it has been prescribed to all T1D patients as a necessary agent to extend life. However, the absolute requirement of treating T1D with insulin was first called into question in the late 1990s. Leptin, a hormone secreted by adipocytes which was first identified by Jeffrey Friedman and colleagues (7) which reduces body weight and normalizes glycemia in leptin-deficient ob/ob mice (8-10), resulted in close to normalization of blood glucose concentrations when infused subcutaneously in streptozotocin (STZ)-induced T1D rats (11).These results have clear clinical implications in humans: although studies have yielded both positive (12-16) and negative results (17)(18)(19) regarding an association of leptin with glycemic control in normoglycemic or mildly hyperglycemic T1D patients, patients in diabetic ketoacidosis (DKA) clearly have lower plasma leptin concentrations than healthy controls (20, 21). These results suggest that leptin may be regulated by insulin, an interpretation bolstered by the fact that leptin production by adipocytes rises with increasing insulin concentrations in vitro (22), during the acute treatment of DKA in T1D subjects (20) and during acute and chronic hyperinsulinemia in some studies in healthy controls (23-25). However, data are mixed regarding the ability of insulin -...

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Serum leptin and adiponectin levels in children with type 1 diabetes mellitus – Relation to body fat mass and disease course

Cited by 18 publications

References 22 publications

Dual X-ray absorptiometry body composition and its associated factors in children and adolescence with type 1 diabetes mellitus in South of Iran, a case-control study

Dual X-ray absorptiometry body composition and its associated factors in children and adolescence with type 1 diabetes mellitus in South of Iran, a case-control study

Correlations of severity of asthma in children with body mass index, adiponectin and leptin

Pleotropic Acute and Chronic Effects of Leptin to Reverse Type 1 Diabetes

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