Correlations of severity of asthma in children with body mass index, adiponectin and leptin

Ma, Chunli; Wang, Yujun; Xue, Ming

doi:10.1002/jcla.22915

Cited by 18 publications

(17 citation statements)

References 20 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It seems that serum adiponectin levels would be related to asthma severity, especially in children [79]. Ma et al [80] analyzed serum adiponectin levels and BMI in 122 asthmatic children, concluding that asthma severity was negatively correlated with adiponectin levels, and positively correlated with BMI. These results are in concordance with previous studies showing that obese and asthmatic children presented an inadequate asthma control and lower serum levels of adiponectin when compared with non-obese asthmatic children [81,82].…”

Section: Anti-inflammatory Adipokines: Adiponectinmentioning

confidence: 99%

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta

González-Bermúdez

García‐Marcos

2020

JCM

View full text Add to dashboard Cite

The Western lifestyle is a complex concept that includes the diet as the main axis of different factors which contribute to a detrimental effect on health, lower life expectancy and low quality-of-life. This type of diet is characterized by being high in calories, mainly provided by saturated fats, and rich in sugars that can lead to changes in immune cells and their responsiveness, by different mechanisms that have yet to be totally clarified. Inflammatory processes are perpetuated through different pathways, in which adipose tissue is a major factor. High fat stores in overweight and obesity accumulate energy but the endocrine function is also producing and releasing different bioactive compounds, adipokines, known to be pro-inflammatory and which play an important role in the pathogenesis of asthma. This review therefore explores the latest evidence regarding the adverse effect of the Western diet on adipose tissue inflammation and its causative effect on the asthma epidemic.

show abstract

Section: Anti-inflammatory Adipokines: Adiponectinmentioning

confidence: 99%

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta

González-Bermúdez

García‐Marcos

2020

JCM

View full text Add to dashboard Cite

show abstract

“…Although OSA is common in pediatric obesity and represents an independent risk factor for metabolic syndrome, an association, independent of excess weight, between Ad and OSA, oxygen desaturation, and percentage of time of sleep in this population could not be demonstrated [77]. However, a recent study performed in a small sample of Chinese children with asthma suggests an inverse correlation between Ad levels and the severity of the disease [78].…”

Section: Adiponectin Obesity and Metabolic Syndromementioning

confidence: 99%

Adiponectin and Cardiovascular Risk. From Pathophysiology to Clinic: Focus on Children and Adolescents

Orlando

Nava

Giussani³

et al. 2019

IJMS

View full text Add to dashboard Cite

Adiponectin (Ad) is a cytokine produced by adipocytes that acts on specific receptors of several tissues through autocrine, paracrine, and endocrine signaling mechanisms. Ad is involved in the regulation of cell survival, cell growth, and apoptosis. Furthermore, Ad plays an important pathophysiological role in metabolic activities by acting on peripheral tissues involved in glucose and lipid metabolism such as skeletal muscle, and the liver. Adiponectin has anti-inflammatory, anti-atherogenic, and insulin-sensitizing effects. For this reason, low levels of Ad are associated with the development of cardiovascular complications of obesity in adulthood. Numerous studies have shown that, even in children and adolescents, Ad is associated with risk factors for cardiovascular diseases. In obese children, reduced levels of Ad have been reported and Ad plasma levels are inversely related with abdominal obesity. Moreover, lower Ad concentrations are associated with the development of metabolic syndrome, insulin resistance and hypertension in pediatric subjects. In addition to a higher prevalence of cardiovascular risk factors, plasma values of Ad are also inversely associated with early organ damage, such as an increase in carotid intima-media thickness. It has been suggested that low Ad levels in childhood might predict the development of atherosclerosis in adulthood, suggesting the possibility of using Ad to stratify cardiovascular risk in obese children. Some evidence suggests that lifestyle modification may increase Ad plasma levels. The aim of this review is to summarize the evidence on the relationship between Ad, obesity, metabolic alterations and hypertension in children and adolescents, and to address the possibility that Ad represents an early marker of cardiovascular risk in pediatric subjects. Furthermore, the effects of non-pharmacological treatment (weight loss and physical activity) on Ad levels are considered.

show abstract

“…In this study, leptin levels were significantly higher in obese and nonobese children with asthma compared to the healthy control group [17]. In the study of Ma et al, Serum leptin levels were measured in asthmatic and healthy children, and a positive correlation was reported between BMI and leptin levels [18]. In a study evaluating 138 children, it was reported that serum leptin levels were significantly higher in obese patients compared to normal weight individuals, and serum leptin levels were 2 times higher in obese patients with asthma compared to those who were obese and did not have asthma [19].…”

Section: Discussionmentioning

confidence: 42%