Serum lead, cadmium, and zinc levels in newborns with neural tube defects from a polluted zone in Mexico

Carrillo-Ponce, María de Lourdes; Martínez-Ordaz, Verónica Araceli; Velasco-Rodríguez, Víctor Manuel; Hernández-García, Andrés; M, Hernández-Serrano; Sanmiguel, F.L. De Luna

doi:10.1016/j.reprotox.2004.07.003

Cited by 31 publications

(13 citation statements)

References 27 publications

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“…Other studies showed that average concentrations of cord blood from healthy children were between 2.02 g/dl and 3.83 g/dl in Poland, 4.82 g/dl in Czechoslovakia, 4.09 g/dl in Taiwan and 2.49 g/dl in our study (Durska et al 2002;Truska et al 1989;Soong et al 1991). Further, a study carried out in Mexico found that serum lead concentrations were above 10 g/dl within 24 days of extra-uterine life in 25% of the children, reXecting an important maternal exposure to these metals (Carrillo-Ponce et al 2004). Until recently, 10 g/dl was considered a "lead level of concern".…”

Section: Discussionmentioning

confidence: 99%

The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?

Tekin

Kayaaltı

Söylemezoğlu

2011

Int Arch Occup Environ Health

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Section: Discussionmentioning

confidence: 99%

The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?

Tekin

Kayaaltı

Söylemezoğlu

2011

Int Arch Occup Environ Health

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“…An environmental cause is any non-genetic factor that increases the risk of NTDs for the exposed individual. Such factors include fetal infection (Nørga˚rd et al 2006), maternal illness (Shaw et al 1998), nutritional deficiencies (Carrillo-Ponce et al 2004), drug ingestion (Brender et al 2004), chemical exposure (Voss et al 2008) and radiation (Vinceti et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Spatial analysis of neural tube defects in a rural coal mining area

Liao

Wang

et al. 2010

International Journal of Environmental Health Research

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Shanxi province in northern China has one of the highest reported prevalence rates of neural tube defects (NTDs) in the world. The current study selected Heshun, the county with the highest rate of NTDs in Shanxi, as a study area and tested whether residence in a coal mining area was a contributing factor. A NTD cluster was detected in an area within 6 km of the coal mines for almost every year during 1998-2005. Poisson regression analysis revealed that there may be an association between production in coal mines and prevalence of NTDs in coal mine areas. Future work identifying factors independently correlated with NTDs in coal mining regions may provide further insights into the health effects of coal mines on NTDs.

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“…Newborns with NTDs have a significantly low level of serum zinc, supporting zinc deficiency as an association of NTDs (6,7). Zeyrek et al .…”

Section: Introductionmentioning

confidence: 99%

Maternal and Neonatal Serum Zinc Level and Its Relationship with Neural Tube Defects

Dey

Shahidullah

Mannan

et al. 2010

J Health Popul Nutr

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Neural tube defect (NTD) is a multi-factorial disorder in which nutritional, genetic and environmental factors are involved. Among the nutritional factors, low level of serum zinc has been reported from different parts of the world. This hospital-based case-control study was conducted with the objective of finding the relationship between serum zinc level in newborns and their mothers and NTDs in a Bangladeshi population. The study was conducted during August 2006–July 2007 at the Bangabandhu Sheikh Mujib Medical University (BSMMU) in Dhaka. In total, 32 mothers and their newborns with NTDs were included as cases and another 32 mothers with their normal babies were included as controls. Concentration of serum zinc was determined by pyro-coated graphite furnace atomic absorption spectrophotometer (GF-AAS). The mean age of the case and control mothers was 25.28 years and 24.34 years respectively. The mean gestational age of the case newborns was 36.59 weeks and that of the control newborns was 37.75 weeks. The mean serum zinc level of the case and control mothers was 610.2 μg/L and 883.0 μg/L respectively (p<0.01). The mean serum zinc level of the case and control newborns was 723 μg/L and 1,046 μg/L respectively (p<0.01). In both case and control groups, the serum zinc level of the newborns positively correlated with that of the mothers. The serum zinc levels of the mothers and newborns negatively correlated with NTDs. Mothers with serum zinc level lower than normal were 7.66 [95% confidence interval (CI) 2.5-23.28] times more likely to have NTDs compared to the normal zinc level of mothers. After adjusting for the zinc level of the newborns, parity, and age of the mothers, this risk reduced 1.61 times [confidence interval (CI) 95% 0.24-8.77]. On the other hand, the low serum zinc level of the newborns was 7.22 times more associated with NTDs compared to the newborns with the normal serum zinc level, which was statistically significant (p=0.001). After adjusting for other factors, such as maternal age and parity, newborns with the low serum zinc level was found to be 9.186 times more likely to be associated with NTDs compared to newborns with normal serum zinc level. Based on the findings, it may be concluded that the low serum zinc levels of newborns may be associated with NTDs. To confirm these findings, a further study with a larger sample-size is recommended. Moreover, a follow-up study with zinc supplementation to pregnant women and its impact on NTDs is also recommended.

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Serum lead, cadmium, and zinc levels in newborns with neural tube defects from a polluted zone in Mexico

Cited by 31 publications

References 27 publications

The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?

The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?

Spatial analysis of neural tube defects in a rural coal mining area

Maternal and Neonatal Serum Zinc Level and Its Relationship with Neural Tube Defects

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