Serum lactate levels and perfusion index: are these prognostic factors on mortality and morbidity in very low-birth weight infants?

Tüten, Abdülhamit; Dinçer, Emre; Topçuoğlu, Sevilay; Sancak, Selim; Akar, Selahattin; Toptan, Handan Hakyemez; Özalkaya, Elif; Gökmen, Tülin; Ovalı, Fahri; Karatekın, Güner

doi:10.1080/14767058.2016.1205019

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…Similarly, in our study, ROP rates were found to be high in preterms with lactate levels >4 mmol/L. However, there was no difference in terms of PDA …”

Section: Discussionsupporting

confidence: 72%

Can lactate levels be used as a marker of patent ductus arteriosus in preterm babies?

Okur

Tayman

Büyüktiryaki

et al. 2018

Clinical Laboratory Analysis

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High lactate levels are multifactorial and usually indicate impairment of tissue perfusion. There are a number of factors that can lead to impaired tissue perfusion in preterm infants. For the first time in this study, it was shown that lactate levels did not significantly increase in the presence of hemodynamically significant PDA. This may be due to the fact that peripheral tissue perfusion in the presence of hemodynamic PDA does not deteriorate enough to cause an increase in anaerobic metabolism.

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“…Similarly, in our study, ROP rates were found to be high in preterms with lactate levels >4 mmol/L. However, there was no difference in terms of PDA …”

Section: Discussionsupporting

confidence: 72%

Can lactate levels be used as a marker of patent ductus arteriosus in preterm babies?

Okur

Tayman

Büyüktiryaki

et al. 2018

Clinical Laboratory Analysis

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“…Some studies reported that high lactate levels and low pH in cord blood within the first day of life predict mortality in premature infants (31,32). Conversely, other studies found no association between umbilical cord acidemia and adverse outcomes in those born at <32 weeks (33,34). Gaudier et al, reported that 1 and 5 min Apgar scores were better predictors of survival than umbilical artery blood gases in 1,073 infants weighing 500-1,000 g at birth (35).…”

Section: Discussionmentioning

confidence: 99%

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

Ohto

Nollet

et al. 2020

Front. Pediatr.

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Background: Platelets participate in many physiological and pathological functions and some platelet parameters predict adult diseases. However, few studies report whether platelet parameters may reflect neonatal disease and mortality in a large cohort.Objective: We aimed to investigate whether platelet parameters could predict bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and NICU mortality. Study Design and Methods:This retrospective cohort study examined records from 2006 to 2017 at the neonatal intensive care unit (NICU) of Fukushima Medical University Hospital. We retrospectively investigated platelet count, plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) on the first day of life in preterm newborns born <32 weeks' gestation admitted to our NICU from 2006 to 2017. Receiver operating characteristic (ROC) and multiple regression analyses, along with Cox proportional hazard modeling, identified independent predictors of morbidities and mortality in preterm newborns.Results: Of 1,501 neonates admitted to our NICU, a total of 305 preterm newborns were included in this study. Gestational age, birth weight, and Apgar score were significantly lower in non-survivors than in survivors. Platelet count, PCT, PDW and PMI did not differ significantly between the two groups, whereas mean MPV in non-survivors was significantly higher than in survivors (10.5 fl vs. 10.0 fl, p = 0.001). Multivariate Cox hazard modeling showed that shorter GA [HR: 0.628, 95% CI: 0.464-0.840, p = 0.003], male sex [HR: 0.269, 95% CI: 0.113-0.640, p = 0.001], and MPV [HR: 1.469, 95% CI: 1.046-2.063, p = 0.026] independently predicted overall survival. Per receiver operating curve, an MPV threshold of 10.2 fl. MPV predicts prognosis in neonates with a sensitivity of 72.4% and a specificity of 58.6% (AUC = 0.685, 95% CI: 0.600-0.789, p = 0.001). Furthermore, multivariate analysis revealed that platelet parameters were not associated Go et al. Platelet Parameters in Neonateswith BPD and NEC, whereas small for gestational age (SGA), Apgar score at 5 min, and low PCT were associated with intraventricular hemorrhage (IVH).Conclusion: This study demonstrates that low PCT predicts IVH, and MPV ≥ 10.2 fL correlates with mortality among infants born after <32 weeks' gestation.

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“…The PI monitoring device with its detector embedded in a pulse oximetry probe can analyze those changes based on the amplitude of the plethysmographic wave (PPGA). PI is a calculated ratio of the pulsatile signal (AC) to the nonpulsatile signal (DC), as expressed in percentage (AC/DC × 100), and it enables the PPGA to be quantified. There are large inter‐individual variations of PI ranging from 0.02 to 20 .…”

Section: Introductionmentioning

confidence: 99%

The prediction probabilities for emergence from sevoflurane anesthesia in children: A comparison of the perfusion index and the bispectral index

et al. 2018

Pediatric Anesthesia

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Serum lactate levels and perfusion index: are these prognostic factors on mortality and morbidity in very low-birth weight infants?

Cited by 17 publications

References 23 publications

Can lactate levels be used as a marker of patent ductus arteriosus in preterm babies?

Can lactate levels be used as a marker of patent ductus arteriosus in preterm babies?

Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study

The prediction probabilities for emergence from sevoflurane anesthesia in children: A comparison of the perfusion index and the bispectral index

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