Can lactate levels be used as a marker of patent ductus arteriosus in preterm babies?

Okur, Nilüfer; Tayman, Cüneyt; Büyüktiryaki, Mehmet; Şimşek, Gülsüm Kadıoğlu; Bekmez, Buse Özer; Altuğ, Nahide

doi:10.1002/jcla.22664

Cited by 6 publications

(6 citation statements)

References 29 publications

(27 reference statements)

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“…This data comes in agreement with the studies of Okur et al and Visconti et al [26,30] which revealed that hsPDA patients have higher mortality rate compared with non-hsPDA patient. On the other hand, Okur et al [26] reported no significant difference between hsPDA group and non-hsPDA groups regarding mortality.…”

Section: Discussionsupporting

confidence: 93%

“…Pulmonary hemorrhage was significantly associated with HS PDA when compared to non-hsPDA (P = 0.031). This data came in agreement with Okur et al [26] who reported no difference in early neonatal sepsis, IVH, BPD between hsPDA and non-hsPDA groups. However, Lee et al [27] found more infants suffering from early sepsis in the PDA group when compared with the non-PDA group.…”

Section: Discussionsupporting

confidence: 93%

“…The number of babies who needed CPAP or were mechanically ventilated and duration of mechanical ventilation were significantly higher in hsPDA when compared to non-hsPDA group (P = 0.007, 0.003, 0.001, respectively). This came in agreement with Okur et al [26] who found that the duration of mechanical ventilation was longer in the hsPDA group when compared to non-hsPDA group.…”

Section: Discussionsupporting

confidence: 92%

“…Okur et al [26] studied a total of 119 patients with gestational age ≤ 32 weeks and birth weight ≤ 1500 gms, his results contrasted with ours regarding birth weight which was lower in hsPDA but agreed with our results concerning length of NICU stay which did not differ significantly between the two groups.…”

Section: Discussionsupporting

confidence: 90%

“…In the current study, PDA group depicted poor Apgar scores (less than 5 at 1 min) when compared to non-PDA group (P = 0.047). Okur et al [26] and Lee et al [27] reported similar results.…”

Section: Discussionmentioning

confidence: 55%

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Patent ductus arteriosus in preterm infants; experience of a tertiary referral neonatal intensive care unit: prevalence, complications, and management

Soliman

Mostafa

AbdelMassih

et al. 2020

Egypt Pediatric Association Gaz

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Background Patent ductus arteriosus poses diagnostic and therapeutic dilemma for clinicians, diagnosis of persistent PDA, and determination of its clinical and hemodynamic significance are challenging. The aim of this study is to determine the prevalence of PDA in preterm infants admitted to our NICU, to report cardiac and respiratory complications of PDA, and to study the management strategies and their subsequent outcomes. Result Echocardiography was done for 152 preterm babies admitted to neonatal intensive care unit (NICU) on day 3 of life. Eighty-seven (57.2%) preterms had PDA; 54 (62.1%) non-hemodynamically significant PDA (non-hsPDA), and 33 (37.9%) hemodynamically significant PDA. Hemodynamically significant PDA received medical treatment (paracetamol 15 mg/kg/6 h IV for 3 days). Follow-up echocadiography was done on day 7 of life. Four babies died before echo was done on day 7. Twenty babies (68.9%) achieved closure after 1st paracetamol course. Nine babies received 2nd course paracetamol. Follow-up echo done on day 11 of life showed 4 (13.7%) babies achieved successful medical closure after 2nd paracetamol course; 5 babies failed closure and were assigned for surgical ligation. The group of non-hsPDA showed spontaneous closure after conservative treatment. Pulmonary hemorrhage was significantly higher in hsPDA group. Mortality was higher in hsPDA group than non-hsPDA group. Conclusion Echocardiographic evaluation should be done for all preterms suspected clinically of having PDA. We should not expose vulnerable population of preterm infants to medication with known side effects unnecessarily; we should limit medical closure of PDA to hsPDA. Paracetamol offers several important therapeutic advantages options being well tolerated and having more favorable side effects profile.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

“…In the current study, PDA group depicted poor Apgar scores (less than 5 at 1 min) when compared to non-PDA group (P = 0.047). Okur et al [26] and Lee et al [27] reported similar results.…”

Section: Discussionmentioning

confidence: 55%

See 3 more Smart Citations

Patent ductus arteriosus in preterm infants; experience of a tertiary referral neonatal intensive care unit: prevalence, complications, and management

Soliman

Mostafa

AbdelMassih

et al. 2020

Egypt Pediatric Association Gaz

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Necrotising Enterocolitis case study from a nurse's perspective

Woodman,

Maguire

2024

Journal of Neonatal Nursing

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Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study

et al. 2021

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Background Patent ductus arteriosus (PDA) is common among preterm neonates. Haemodynamically significant ductus arteriosus (hsPDA) can cause ductal steal and contribute to poor outcomes. Our aim was to evaluate ductus arteriosus patency and significance using two-site near-infrared spectroscopy (NIRS) measurements in preterm infants older than 72 h as a supplemental tool to echocardiography. Methods In this prospective observational study, 123 preterm infants (gestational age (GA) < 32 weeks, birth weight < 1500 g) were enrolled. Sixty-four newborns had closed ductus arteriosus (noPDA), and 41 and 18 patients were assigned to the PDA and hsPDA groups, respectively, per predefined echocardiographic criteria. Cerebral and renal oxygenation were assessed during NIRS monitoring. Results A higher renal mean (±SD) regional tissue oxygen saturation (rSpO2) (76.7 (±7.64)) was detected in the noPDA group than in the PDA (71.7 (±9.02)) and hsPDA (67.4 (±13.48)) groups (p < 0.001). Renal fractional tissue oxygen extraction (FTOE) (0.18 (±0.079)) was lower in the noPDA group than in the PDA (0.23 (±0.092)) and hsPDA (0.24 (±0.117))0.117 groups (p = 0.002). Cerebral oxygenation was significantly lower in the hsPDA group (77.0 (±5.16)) than in the noPDA (79.3 (±2.45)) and PDA (79.7 (±2.27)) groups (p = 0.004). There was no significant difference in cerebral fractional tissue oxygen extraction (FTOE) between any of the groups. Conclusions Our results suggest that renal oxygenation is affected by ductus patency in preterm infants older than 72 h. Significant differences in cerebral oxygenation were observed between the hsPDA group and the PDA and noPDA groups. Trial registration ClinicalTrials.gov Identifier: NCT04295395. Registration date: 4 March 2020. This study was retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04295395.

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Can lactate levels be used as a marker of patent ductus arteriosus in preterm babies?

Cited by 6 publications

References 29 publications

Patent ductus arteriosus in preterm infants; experience of a tertiary referral neonatal intensive care unit: prevalence, complications, and management

Patent ductus arteriosus in preterm infants; experience of a tertiary referral neonatal intensive care unit: prevalence, complications, and management

Necrotising Enterocolitis case study from a nurse's perspective

Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study

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