Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy

Guo, Yang; Zhuang, Xiaodong; Xian, Wenbiao; Wu, Lingling; Huang, Zhemin; Hu, Xun; Zhang, Xiangsong; Chen, Ling; Liao, Xinxue

doi:10.1111/cns.12711

Cited by 18 publications

(13 citation statements)

References 56 publications

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“…For example, secreted or soluble Klotho in the serum has been shown to reduce neuronal loss and neurodegeneration (Abraham et al, 2012), promote stem cells (Bian et al, 2015), and protects the heart from hyperglycemia-induced injury (Guo et al, 2018). In addition, the level of serum Klotho has been also utilized to predict the onset of multiple system atrophy (Guo et al, 2017). Thus, releasable Klotho present a very interesting humoral factor that could be helpful to find new means against neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Jing

Liu

et al. 2019

Front. Cell. Neurosci.

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The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellular Klotho form can be expressed and secreted. Inactivation of α-Klotho leads to a phenotype that resembles accelerated aging, as the expression level of the α-Klotho protein in the hippocampal formation of mice decreases with age. Here, we show that intrahippocampal viral expression of secreted human α-Klotho alters social behavior and memory formation. Interestingly, overexpression of secreted human α-Klotho in the CA1 changed the nest-building behavior and improved object recognition, object location and passive avoidance memory. Moreover, α-Klotho overexpression increased hippocampal synaptic transmission in response to standardized stimulation strengths, altered paired-pulse facilitation of synaptic transmission, and enhanced activity-dependent synaptic plasticity. These results indicate that memory formation benefits from an augmented level of secreted α-Klotho.

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Section: Discussionmentioning

confidence: 99%

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Jing

Liu

et al. 2019

Front. Cell. Neurosci.

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“…There is evidence for depleted circulatory vitamin D3 levels and increased risk of PD [ 48 ], AD [ 49 , 50 ], and ALS [ 51 ]. In the less common neurodegenerative disorders, vitamin D3 deficiency has been reported in MSA [ 52 , 53 ].…”

Section: Nutrient Deficiency In Neurodegenerative Disordersmentioning

confidence: 99%

Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

Mantle

Hargreaves

2022

IJMS

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Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders, including Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, multisystem atrophy, and progressive supranuclear palsy. This article is concerned specifically with mitochondrial dysfunction as defined by reduced capacity for ATP production, the role of depleted levels of key nutritionally related metabolites, and the potential benefit of supplementation with specific nutrients of relevance to normal mitochondrial function in the above neurodegenerative disorders. The article provides a rationale for a combination of CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid for the treatment of the above neurodegenerative disorders.

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“…Since MSA shares neuropathogenesis similarities with PD, the exact roles of vitamins in MSA remain to be investigated. Although several studies have analyzed the alternation of vitamins in MSA, the findings in relative small size were controversial ( Chen et al, 2015 ; Zhang et al, 2015 ; Guo et al, 2017 ), making it necessary to validate the association of vitamins with MSA in the larger cohorts.…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin levels in multiple system atrophy: A case-control study

Chen

Wan

Chen

et al. 2023

Front. Aging Neurosci.

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AimThere is increasing evidence suggesting that vitamins may play important roles in the pathogenesis of multiple system atrophy (MSA). The purpose of this study was to detect the changes of serum vitamin levels and investigate their correlation with disease severity in MSA patients.MethodsIn this cross-sectional study, 244 MSA patients, 200 Parkinson’s disease (PD) patients and 244 age-gender matched healthy controls were recruited. Serum vitamin levels were measured, including vitamin A, B1, B2, B9 (folate), B12, C, D, and E. Relevant clinical scales were used to assess the disease severity of MSA patients.ResultsCompared with the healthy controls, decreased serum folate levels and increased serum vitamin A and C levels were detected in MSA patients. Similar differences were also observed in the gender-based subgroup analysis. There were no differences detected between MSA and PD patients. In MSA patients, significant correlation was found between vitamin A, folate, or vitamin C and relevant clinical scales or laboratory findings. In addition, ROC analysis showed potential diagnostic value of the combination of vitamin A, folate, and vitamin C in distinguishing MSA patients from healthy controls.ConclusionThere were significant changes in the blood vitamin spectrums of MSA patients, suggesting that dysregulation of vitamins homeostasis might play an important role in the pathogenesis of MSA.

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Serum Klotho, vitamin D, and homocysteine in combination predict the outcomes of Chinese patients with multiple system atrophy

Abstract: This study suggested that Klt, 25(OH)D and Hcy levels could be a potential predictor for MSA severity evaluation.

Cited by 18 publications

References 56 publications

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

Serum vitamin levels in multiple system atrophy: A case-control study

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